A5058073359- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Biomarkers in Disease Mechanisms
- Diabetes Management and Education
- Ubiquitin and proteasome pathways
- Apelin-related biomedical research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Macrophage Migration Inhibitory Factor
- Adipokines, Inflammation, and Metabolic Diseases
- Meningioma and schwannoma management
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Hip and Femur Fractures
- Sepsis Diagnosis and Treatment
Sun Yat-sen Memorial Hospital
2015-2022
Sun Yat-sen University
2009-2022
Abstract Papillary thyroid cancer (PTC) is a common endocrine system malignancy all over the world. Aberrant expression of six transmembrane epithelial antigen prostate 2 (STEAP2) has been functionally associated with progression in many cancers. Nevertheless, its biological function PTC still unclear. Here, we found that tissues had preferentially downregulated STEAP2 as compared noncancerous tissues. Low correlated aggressive clinicopathological characteristics and dismal prognosis...
Introduction The aim of present study was to profile the glucose-dependent and glutamine- dependent metabolism in pancreatic cancer. Methods We performed Immunohistochemical staining GLUT1, CAIX, BNIP3, p62, LC3, GLUD1, GOT1. Based on expression metabolism-related proteins, metabolic phenotypes tumors were classified into two categories, including glucose- glutamine-dependent metabolism. There Warburg type, reverse mixed null type metabolism, canonical non-canonical Results Longer overall...
Understanding the pathogenic mechanism of pancreatic cancer associated diabetes (PCDM) might help yield biomarkers for early diagnosis (PC) from population with new-onset diabetes. In current study, we sought to determine role macrophage migration inhibitory factor (MIF) in PCDM pathogenesis. The protein and mRNA levels MIF paraffin-embedded human PC samples, chronic pancreatitis specimens, normal pancreas were measured by immunohistochemistry quantitative reverse-transcriptase polymerase...
Thyroid cancer is the most common malignancy of endocrine system, and its outcome remains unsatisfactory. In recent years, circular RNAs (circRNAs) have emerged as crucial regulators in cancers. current study, we aimed to investigate whether how circRNA_0057209 functioned thyroid cancer. Initial results revealed that STK4 were both reduced, while miR-183 was up-regulated tissues cells. Experiments including RNA pull-down RIP assays further identified upregulation augmented expression STK4, a...
Abstract Background Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating miR-376c-3p/DNM3 axis. However, regulation mechanism expression in PTC is still unclear. Methods The luciferase reporter ChIP assays were used to confirm binding LEF-1 putative promoter site gene. RNA immunoprecipitation pulldown determine enrichment β-catenin protein. proteasome inhibitors (MG132) was for detecting...
The association of the international normalized ratio (INR) with long‑term clinical outcome patients who undergo endarterectomy has not yet been studied. present study therefore primarily aimed to evaluate INR on admission 90‑day mortality critically ill underwent during hospitalization. Medical Information Mart for Intensive Care III database was queried undergoing endarterectomy. selected as a primary endpoint. Receiver‑operating characteristic (ROC) curves were plotted accuracy...
Abstract Aim To explore the application of intraoperative neurological monitoring in residual thyroidectomy 5–15 days after thyroid cancer operation and influence on postoperative serum thyroglobulin (Tg), recurrent laryngeal nerve function parathyroid glands. Methods Material patients receiving surgery from January 2010 to December 2016 was retrospectively analyzed. Cases meeting with standards were enrolled for analysis divided into group non‐neurological line use during operation....
Abstract Objective: To explore the clinical value of radical nerve dissection (RND) for carcinoma head pancreas (CHP). Methods: The and pathological data 30 CHP patients who underwent RND in our hospital were retrospectively analyzed, with an attempt to safety short-term efficacy this procedure. Results: Among these patients, operative time was (351±61) min, intra-operative blood loss 350 (range, 300-600) mL, grades B C pancreatic fistula 23.33%. During follow-up 2-30 months; median: 17...
Objective To explore the gene expression profiles related to pathogenesis of pancreatic cancer associated diabetes (PCA-DM) and provide new clues for study PCA-DM. Methods The tissues four patients with ductal adenocarcinoma (PCA-DM), without (PC) chronic pancreatitis (CP) were analyzed by microarrays individually, following box diagram, volcano heat map analysis, interaction network analysis; chromosome positioning ontology (GO) RT-PCR was used confirm results. Results Data...