A5090192901- Spine and Intervertebral Disc Pathology
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Musculoskeletal pain and rehabilitation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Medicinal Plant Pharmacodynamics Research
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Bone Metabolism and Diseases
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Rheumatoid Arthritis Research and Therapies
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Spondyloarthritis Studies and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer Research and Treatments
- Medical Imaging and Analysis
- Cancer Immunotherapy and Biomarkers
- Brain Tumor Detection and Classification
Tsinghua University
2025
Affiliated Hospital of Southwest Medical University
2022-2024
Nanchong Central Hospital
2024
Wuhan University of Technology
2024
Huazhong University of Science and Technology
2017-2023
Union Hospital
2017-2023
Nanyang Technological University
2020-2022
Central South University
2022
Hubei University of Technology
2021
Union Hospital
2017-2020
Bone repair and regeneration are greatly influenced by the local immune microenvironment. In this regard, immunomodulatory capability of biomaterials should be considered when evaluating their osteogenic effects. study, we investigated modulatory effects gold nanoparticle (AuNP)-loaded mesoporous silica nanoparticles (Au-MSNs) on macrophages subsequent behavior osteoblastic lineage cells. The results demonstrate that Au-MSNs could generate a favorable microenvironment stimulating an...
Conventional therapeutic approaches to treat malignant tumors such as surgery, chemotherapy, or radiotherapy often lead poor results, great pain, economic burden, and risk of recurrence may even increase the difficulty in treating patient. Long-term drug administration systemic delivery for cancer chemotherapy would be accompanied by resistance unpredictable side effects. Thus, use photothermal therapy, a relatively rapid tumor elimination technique that regulates autophagy exerts an...
Background: Precise control and induction of the differentiation stem cells to osteoblasts by artificial biomaterials are a promising strategy for rapid bone regeneration reconstruction. Purpose: In this study, gold nanoparticles (AuNPs)-loaded hydroxyapatite (HA-Au) nanocomposites were designed guide osteogenic human marrow-derived mesenchymal (hMSCs) through synergistic effects both AuNPs HA. Materials methods: The HA-Au synthesized characterized several analytical techniques. Cell...
Objective . Excessive apoptosis of nucleus pulposus cells (NPCs) induced by various stresses, including compression, contributes to the development intervertebral disc degeneration (IVDD). Mesenchymal stem (MSCs) can benefit regeneration NPCs and delay IVDD, but underlying molecular mechanism is poorly understood. This study aimed evaluate antiapoptosis effects bone marrow-derived MSC (BMSC) on rat exposed compression investigate whether mitochondrial pathway was involved. Methods. BMSCs...
Rationale: Mesenchymal cell-derived osteosarcoma is a rare malignant bone tumor affecting children and adolescents. PTEN down-regulation or function-loss mutation associated with the aggressive of osteosarcoma. Explicating regulatory mechanism might highlight new targets for improving survival rate patients. Methods: The clinical relevance FGD1 was examined by TCGA data set, Western blotting immunohistochemistry microarray slides. Functional assays, such as MTS assay, colony formation assay...
Biomimetic functionalization is a pressing need for orthopedic implants to achieve reinforced osseointegration and accelerated osteogenesis, thereby obtaining successful clinical outcome. To realize bioactivity, TiNb alloys with varying Nb contents (0–45 at.%) were additively manufactured using elemental powder blends. The regulation of the could balance surface constituent ratio Nb2O5 TiO2, enhancing formation hydroxyl group hydrophilicity. Moreover, effect mechanism on immune modulation...
Accumulated evidence indicates that cholesterol is offensive to bone metabolism. Therefore, we examined the real-world study among total and mineral density (BMD). We investigated relationship between BMD 10,039 US participants aged 20-59 years old over period 2011-2018 from NHANES.To analyze BMD, multivariate linear regression models were used. Fitted smoothing curves, generalized additive models, threshold effect analysis also conducted.After adjusting for additional covariates, weighted...
This study describes an efficient chemical synthesis method of d -Dpo4, a valuable enzymatic tool producing mirror-image DNAs, using one-pot multi-segment condensation strategy.
Abstract The current research aimed to explore the possible relationship between PINK1/PARKIN‐mediated mitophagy and compression‐induced senescence of nucleus pulposus cells (NPCs). Therefore, stages in NPCs were measured under compression lasting 0, 24 48 hours. mitophagy‐related markers, autophagosomes mitochondrial membrane potential tested determine levels compression. PINK1 PARKIN also by immunohistochemistry human rat intervertebral disc (IVD) tissues taken at different degenerative...
Puerarin (PUR), an 8-C-glucoside of daidzein extracted from Pueraria plants, is closely related to autophagy, reduced reactive oxygen species (ROS) production, and anti-inflammatory effects, but its effects on human nucleus pulposus mesenchymal stem cells (NPMSCs) have not yet been identified. In this study, NPMSCs were cultured in a compression apparatus simulate the microenvironment intervertebral disc under controlled pressure (1.0 MPa), we found that cell viability was decreased...
To validate the clinical value of new Ankylosing Spondylitis Disease Activity Scores (ASDASs) in assessing disease activity and efficacy TNF-α inhibitor AS uSpA patients China.Two hundred thirty were included our study. They consisted with active (n = 87) 30) participating a double-blind placebo-controlled randomized trial etanercept 58) 55) treated infliximab. The treatment effects assessed by ASDAS, BASDAI, patient global acute inflammation score lumbar SI joints MRI. Discriminatory...
Patients with osteosarcoma exhibiting resistance to chemotherapy or presenting metastasis usually have a poor prognosis. Osteosarcoma stem cells (OSCs) are potential cause of tumor metastasis, relapse, and resistance. Therefore, it is necessary develop novel therapeutic drugs, which not only kill but also target OSCs. This study aims explore the anti-osteosarcoma effects Bruceine D (BD), natural compound derived from Brucea javanica, investigate its underlying mechanisms. Results...
To explore the effect and possible mechanism of icariin, a prenylated flavonol glycoside derived from Chinese herb Epimedium sagittatum that was applied to IL-1β pretreated human nucleus pulposus (NP) cells.Human NP cells were isolated intervertebral discs patients with scoliosis lumbar spondylolisthesis. The divided into five groups: A (blank control); B (20 ng/ml IL-1β); C + 20 μM icariin); D icariin 25 LY294002); E LY294002). For each groups, CCK8, apoptosis rates, ROS JC-1 rates...
Purpose: Reactive oxygen species (ROS) are related to compression stress-induced nucleus pulposus (NP) cell autophagy, but the specific mechanism is unknown in intervertebral disc degeneration (IVDD). Here, we discuss molecular and explore whether ROS scavengers could be employed as drugs inhibit IVDD.Methods: Rat NP cells were exposed 1.0 MPa pretreatment with scavenger N-acetylcysteine (NAC) or JNK-selective inhibitor SP600125 not. Intracellular production was monitored by confocal...
Osteosarcoma often presents the low response to chemotherapy, which brings difficulties treatment. Recently, it has become a new idea use photothermal effect and Fenton/Fenton-like reaction treat tumors or enhance killing of chemotherapy drugs. We developed an iron-containing nanomaterial SiO2@PDA/Fe3+-FA (PDA: polydopamine; FA: folate) chemotherapy-insensitive osteosarcoma. The been proven have: (1) high drug delivery efficiency (doxorubicin cisplatin: 21.25% 23.80% respectively), (2)...
Purpose . Mechanical loading plays a vital role in the progression of intervertebral disc (IVD) degeneration, but little is known about effect compression on human nucleus pulposus-derived mesenchymal stem cells (NP-MSCs). Thus, this study aimed at investigating biological behavior NP-MSCs vitro. Methods Human were isolated from patients undergoing lumbar discectomy for IVD degeneration and identified by immunophenotypes multilineage differentiation. Then, cultured apparatus 1.0 MPa...
Vascular endothelial growth factor (VEGF) is a critical regulator of malignant pleural effusion (MPE) in non-small-cell lung cancer (NSCLC). Bevacizumab (BEV) and apatinib (APA) are novel VEGF blockers that inhibit cell proliferation the development effusion.In this study, we established Lewis (LLC) xenograft mouse models to compare therapeutic effect APA BEV combination with cisplatin (CDDP) against MPE. The anti-tumour anti-angiogenic effects therapy were evaluated by 18F-FDG PET/CT...
Massive increases in the risks of depressive disorders and ensuing suicide have become overarching menace for children/adolescents. Despite global consensus to instigate psychological healthcare policy these children/adolescents, their effects remain largely unclear neither from a small amount official data nor small-scale scientific studies. More importantly, underprivileged children/adolescents lower-middle-economic-status countries/areas, collection may not be as equally accessible...
It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 gene might be linked to susceptibility of musculoskeletal degenerative diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD). However, data from different studies is contradictory. Here we aimed comprehensively summarize clarify relationship between SNP diseases. Seven eligible including 1339 cases 5406 controls were screened out PubMed, Web Of Science Cochrane library...