A5061918867- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Renal cell carcinoma treatment
- Renal and related cancers
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Paleopathology and ancient diseases
- Biochemical and Molecular Research
- Kruppel-like factors research
- Protein Degradation and Inhibitors
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Cassava research and cyanide
- Insect Utilization and Effects
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
Wuhan University
2018-2024
Renmin Hospital of Wuhan University
2021-2024
Guilin Medical University
2024
Hubei University
2018-2024
The First People's Hospital of Guiyang
2021
Zhongnan Hospital of Wuhan University
2020
Xiamen University
2008
Energy stress is an unfavorable condition that tumor cells are often exposed to. Ferroptosis considered emerging target for therapy. However, the role of ferroptosis in energy renal cancer currently unknown. In this study, we found glucose deprivation significantly enhanced GPX4-dependent through AMPK activation. Further, activation suppressed GPX4 expression at transcriptional level upregulation P53 expression. Additionally, inactivation JAK2/STAT3 transcriptionally promoted expression,...
The tetraspanin protein superfamily participate in the dynamic regulation of cellular membrane compartments expressed a variety tumor types, which may alter biological properties cancer cells such as cell development, activation, growth and motility. role 7 (TSPAN7) has never been investigated bladder (BCa). In this study, we aimed to investigate function TSPAN7 its therapeutic potential human BCa. First, via reverse transcription quantitative real-time PCR (qRT-PCR), observed downregulation...
T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of progenitors. The major challenges in treatments T-ALL dose-limiting toxicities chemotherapeutics drug resistance. Despite important progress deciphering genomic landscape T-ALL, translation these findings into effective targeted therapies remains largely unsuccessful. New agents with significant antileukemic efficacy less toxicity urgent need. We...
Abstract T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with complicated heterogeneity. Although expression profiling reveals common elevated genes in distinct T-ALL subtypes, little known about their functional role(s) and regulatory mechanism(s). We here show that SHQ1, H/ACA snoRNP assembly factor involved snRNA pseudouridylation, highly expressed T-ALL. Mechanistically, oncogenic NOTCH1 directly binds to the SHQ1 promoter activates its transcription....
Abstract Background Nuclear receptor subfamily 1 group H member 4 (NR1H4) have been reported in various cancer types, however, little is known about the clinical values and biological function clear cell Renal carcinoma (ccRCC). Methods The expression pattens of NR1H4 ccRCC were investigated specimens, lines publicly‑available databases. Cell Counting Kit-8 (CCK-8), colony formation, 5-ethynyl-2' -deoxyuridine (EdU), transwell wound healing assays performed to assess functions 786-O cells....
Abstract Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial‐to‐mesenchymal transition (EMT) associated with immune evasion can contribute to resistance. Here, the involvement STAM Binding Protein Like 1 (STAMBPL1) reported in development phenotypes KIRC cells. Mechanistically, STAMBPL1 elevated protein abundance surface...
Multiple studies have established a strong relationship between circRNA and cancer progression. Cervical lymph node metastasis is key factor influencing the surgical approach distant of papillary thyroid (PTC). However, role circNDST1 in PTC has not been investigated. Our research focused on revealing function mechanism action PTC. High-throughput sequencing qPCR were used to assess expression tissues with extensive cervical cell lines, respectively. The proliferative effects vitro vivo...
Substrate reduction therapy with analogs reduces the accumulation of substrates by inhibiting metabolic pathways involved in their biosynthesis, providing new treatment options for patients primary hyperoxalurias (PHs) that often progress to end-stage renal disease (ESRD). This research aims evaluate inhibition efficacy Hydroxy-L-proline (HYP) against calcium oxalate (CaOx) crystal formation Drosophila Melanogaster (D. Melanogaster) comparing them Pyridoxine (Vitamin B6). Three stocks (W118,...
Abstract Growth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein‐like family, has been rarely studied, and the clinical importance biological functions GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In present study, we found that was downregulated KIRC. Aberrant downregulation related to clinicopathological feature unfavourable prognosis KIRC patients. overexpression inhibited proliferation, migration invasion vitro vivo....
Abstract Deregulation of v-myc avian myelocytomatosis viral oncogene homolog (MYC) occurs in a broad range human cancers and often predicts poor prognosis resistance to therapy. However, directly targeting oncogenic MYC remains unsuccessful, indirectly inhibiting emerges as promising approach. Checkpoint kinase 1 (CHK1) is protein that coordinates the G2/M cell cycle checkpoint protects cancer cells from excessive replicative stress. Using c-MYC-mediated T-cell acute lymphoblastic leukemia...
Background Osteoporosis affects the quality of life among middle-aged and elderly individuals. In addition, dysfunction osteoblasts can lead to progression osteoporosis. Circular (circ)RNAs are involved in various types diseases, including Moreover, it has been reported that hsa_circ_0001275 expression is upregulated However, effects on growth remain unclear. Methods present study, gene protein levels hFOB1.19 cells were detected via reverse transcription-quantitative (RT-qPCR) western blot...
DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved cancer development remain unknown.The inhibition was used by SGC0946 short hairpin RNA silencing. Monodansylcadaverine staining transmission electron microscope were performed to detect autophagy changes as result DOT1L. MitoTracker Red assay analyze mitochondrial morphology. The markers mitochondria-related proteins analyzed Western blot, qPCR, or...
Abstract The gut microbiome is a key partner of animals, influencing various aspects their physiology and behaviors. Among the diverse behaviors regulated by microbiome, locomotion vital for survival reproduction, although underlying mechanisms remain unclear. Here, we reveal that modulates locomotor behavior Drosophila larvae via specific neuronal type in brain. crawling speed germ‐free (GF) was significantly reduced compared to conventionally reared larvae, while feeding excretion were...
Renal cell carcinoma (RCC) ranks as a prevalent malignant neoplasm, with clear renal (ccRCC, also known KIRC) accounting for approximately 75% of all RCC cases. The farnesoid X receptor (FXR, encoded by NR1H4), functioning nuclear receptor, plays crucial role in regulating gene transcription. Although the involvement FXR tumors digestive system and acute kidney injury has been extensively studied, its specific pathogenesis ccRCC yet to be thoroughly investigated. Consequently, objective our...