A5027064795- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Microbial Community Ecology and Physiology
- Mycobacterium research and diagnosis
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Nanomaterials for catalytic reactions
- Endoplasmic Reticulum Stress and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Membrane Separation Technologies
- Bone Metabolism and Diseases
- Phagocytosis and Immune Regulation
- Indigenous Studies and Ecology
- Cell Adhesion Molecules Research
- Dialysis and Renal Disease Management
- Folate and B Vitamins Research
Northwest Institute of Eco-Environment and Resources
2024-2025
Chinese Academy of Sciences
2024-2025
University of Chinese Academy of Sciences
2024-2025
Wuhan University
2019-2025
Renmin Hospital of Wuhan University
2019-2025
Hangzhou City University
2025
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
First Affiliated Hospital of Wannan Medical College
2024
Extensive evidence has demonstrated that oxidative stress, pyroptosis, and proinflammatory programmed cell death are related to renal ischemia/reperfusion (I/R) injury. However, the underlying mechanism remains be illustrated. Protein arginine methylation transferase 5 (PRMT5), which mediates involved in regulation of epigenetics, exhibits a variety biological functions essential roles diseases. The present study investigated role PRMT5 stress pyroptosis induced by I/R injury mouse model...
Endoplasmic reticulum (ER) stress, pyroptosis, and apoptosis are critical molecular events in the occurrence progress of renal ischemia reperfusion (I/R) injury. Naringenin (4 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mo>′</a:mo> </a:math> ,5,7-trihydroxyflavanone) is one most widely consumed flavonoids with powerful antioxidant anti-inflammatory activities. However, whether naringenin able to relieve I/R injury corresponding mechanisms have not been fully clarified....
Energy stress is an unfavorable condition that tumor cells are often exposed to. Ferroptosis considered emerging target for therapy. However, the role of ferroptosis in energy renal cancer currently unknown. In this study, we found glucose deprivation significantly enhanced GPX4-dependent through AMPK activation. Further, activation suppressed GPX4 expression at transcriptional level upregulation P53 expression. Additionally, inactivation JAK2/STAT3 transcriptionally promoted expression,...
Tumor mutation burden (TMB) and VHL play a crucial role in the management of patients with clear cell renal carcinoma (ccRCC), such as guiding adjuvant chemotherapy improving clinical outcomes. However, time-consuming expensive high-throughput sequencing methods severely limit their applicability. Predicting intratumoral heterogeneity poses significant challenges biology settings. Our aimed to develop self-supervised attention-based multiple instance learning (SSL-ABMIL) model predict TMB...
Purpose: Exploring the value of predicting WHO/ISUP grade clear cell renal carcinoma (ccRCC) using computed tomography urography (CTU) images, providing valuable recommendations for treatment ccRCC. Method: CTU images from Renmin Hospital Wuhan University (RHWU) cohort, including 328 patients with ccRCC, were retrospectively collected. The corticomedullary (CMP) phase features ccRCC extracted Pyradiomics package, and key selected through Least Absolute Shrinkage Selection Operator (LASSO)...
The connection between metabolic reprogramming and tumor progression has been demonstrated in an increasing number of researches. However, further research is required to identify how affects interpatient heterogeneity prognosis clear cell renal carcinoma (ccRCC). In this work, single-cell RNA sequencing (scRNA-seq) based deconvolution was utilized create a malignant hierarchy with differences investigate the relationship biomarkers prognosis. Simultaneously, we created machine...
To explore the effects of puerarin on renal ischemia/reperfusion injury and possible mechanism. The experimental mice were injected with (50 or 100 mg/kg) per day equal sterile saline by intraperitoneal injection for one week, a I/R model was constructed. HK-2 cells incubated (1 uM 10 uM) before H/R model. Immunohistochemistry, immunocytochemistry, Western blot analysis used to detect protein associated apoptosis endoplasmic reticulum stress. Puerarin could improve function attenuate tissue...
710 Background: Bladder cancer with high expression of human epidermal growth factor receptor 2 (HER2) is associated pathological malignancy and poor prognosis. For patients muscle-invasive bladder that can be curative resected, the standard treatment radical cystectomy pelvic lymph node dissection following neoadjuvant chemotherapy (NAC). However, NAC inefficient, many cannot tolerate its adverse reactions. Therefore, a novel safe strategy for these needed after NAC. Methods: In this study,...
Clear cell renal carcinoma (ccRCC), the major histopathological subtype of cancer, is sensitive to ferroptosis. MIT-domain containing protein 1 (MITD1) has been reported play an important role in hepatocellular carcinoma, while it remains unclear whether MITD1 involved ccRCC. Based on available data The Cancer Genome Atlas, we found expression increased through bioinformatics analysis and high suggests a poor prognosis. And validated that expressed significantly ccRCC Western blot analysis....
Abstract Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial‐to‐mesenchymal transition (EMT) associated with immune evasion can contribute to resistance. Here, the involvement STAM Binding Protein Like 1 (STAMBPL1) reported in development phenotypes KIRC cells. Mechanistically, STAMBPL1 elevated protein abundance surface...
Radiation protection is an important field of study, as it relates to human health and environmental safety. Radiation-resistance mechanisms in extremophiles are a research hotspot, this knowledge has great application value bioremediation development anti-radiation drugs. Mount Everest, extreme environment high radiation exposure, harbors many bacterial strains resistant radiation. However, owing the difficulties studying them because terrain, remain unexplored. In novel species (herein,...