A5034330372- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2022-2025
Energy stress is an unfavorable condition that tumor cells are often exposed to. Ferroptosis considered emerging target for therapy. However, the role of ferroptosis in energy renal cancer currently unknown. In this study, we found glucose deprivation significantly enhanced GPX4-dependent through AMPK activation. Further, activation suppressed GPX4 expression at transcriptional level upregulation P53 expression. Additionally, inactivation JAK2/STAT3 transcriptionally promoted expression,...
Clear cell renal carcinoma (ccRCC), the major histopathological subtype of cancer, is sensitive to ferroptosis. MIT-domain containing protein 1 (MITD1) has been reported play an important role in hepatocellular carcinoma, while it remains unclear whether MITD1 involved ccRCC. Based on available data The Cancer Genome Atlas, we found expression increased through bioinformatics analysis and high suggests a poor prognosis. And validated that expressed significantly ccRCC Western blot analysis....