A5103081959- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Protein Kinase Regulation and GTPase Signaling
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Gut microbiota and health
- Immune cells in cancer
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- NF-κB Signaling Pathways
- Melanoma and MAPK Pathways
- Protein Tyrosine Phosphatases
- Hepatitis B Virus Studies
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
- Blood donation and transfusion practices
Second Military Medical University
2002-2023
Eastern Hepatobiliary Surgery Hospital
2002-2023
Ningxia Medical University
2018-2022
Ningxia Medical University General Hospital
2018-2022
Stowers Institute for Medical Research
2002
Stanford University
2002
University of Bergen
2002
Institute for Systems Biology
2002
University of Washington
2002
University of Alabama at Birmingham
2002
Abstract Adult hepatic progenitor (oval) cells are facultative stem in liver, which participate a range of human liver diseases, including hepatocellular carcinoma (HCC). However, the molecular pathways regulating expansion and differentiation these poorly understood. We show that active Wnt/β-catenin signaling occurs preferentially within oval cell population, forced expression constitutively β-catenin mutant promotes population regenerated liver. More importantly, we identify subpopulation...
Increasing evidence suggests that the presence of endotoxemia is substantial clinical relevance to patients with cirrhosis, but it unclear whether and how gut-derived LPS amplifies tumorigenic response liver. We found circulating levels were elevated in animal models carcinogen-induced hepatocarcinogenesis. Reduction using antibiotics regimen rats or genetic ablation its receptor Toll-like 4 (TLR4) mice prevented excessive tumor growth multiplicity. Additional investigation revealed TLR4...
Hepatitis B virus X (HBx) protein is implicated in hepatitis (HBV)–associated liver carcinogenesis. However, it remains unclear whether HBx–expressing hepatic progenitor cells (HPCs) are attributed to tumor formation. In this study, by using HBx transgenic mice and a 3,5–diethoxycarbonyl–1,4–dihydrocollidine (DDC)–induced injury model, the relationship between expression tumorigenicity of HPCs was analyzed. Compared with control mice, an elevated number EpCAM+ characteristics observed after...
The aim of the present study was to investigate effects prebiotics (containing fructooligosaccharides, xylooligosaccharides, polydextrose, and resistant dextrin) intake on immune function intestinal microbiota structure in perioperative patients with colorectal cancer (CRC).A randomized, double-blind, no-treatment parallel control clinical trial involving 140 (90 men 50 women, aged 40-75 y) CRC performed. Patients were randomly divided into two groups: an intervention group (prebiotic group,...
Increasing evidence indicates that long noncoding RNAs (lncRNAs) function as important regulators in biological processes and are dysregulated various tumors. The lncRNA DANCR functions an oncogene cancers, but elucidation of its role pancreatic cancer (PC) requires further investigation. In the current study, we demonstrate was increased PC tissues cell lines. Knockdown significantly suppressed proliferation, migration, invasion influenced levels epithelial-to-mesenchymal...
A novel, p125<sup>FAK</sup> homologue, CADTK, has been detected in neural, epithelial, or hematopoietic cells but not fibroblasts. We now demonstrate CADTK expression a mesenchymal cell, rat aortic smooth muscle (RSMC). Angiotensin II (Ang II) platelet-derived growth factor (PDGF-BB and PDGF-AA) markedly stimulated tyrosine phosphorylation RSMC did affect phosphorylation. The PDGF-dependent was slower more prolonged than that of Ang II, correlating well with the differential effects these...
In the rat liver epithelial cell lines GN4 and WB, angiotensin II (Ang II) activates Gq class of regulatory G-proteins, increasing intracellular calcium, protein kinase C activity, tyrosine phosphorylation. We compared ability Ang other compounds that increase calcium (i.e. ionophore A23187 thapsigargin) or activity (the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) to activate p70 ribosomal S6 (p70S6K) p90 (p90RSK). cells, stimulated p70S6K in a rapamycin- wortmannin- sensitive...
Local recurrence is a therapeutic challenge for radiofrequency ablation (RFA) in treatment of small solid focal malignancies. Here we show that RFA induced heat shock proteins (HSPs) expression and high mobility group box-1 (HMGB1) translocation xenografted melanoma, which might create proinflammatory microenvironment favors tumor antigen presentation activation the effector T cells. On this basis, investigate whether prime-boost strategy combining prime with heat-shocked cell lysate-pulsed...
Robust clinical and epidemiologic data support the role of inflammation as a key player in hepatocellular carcinoma (HCC) development. Our previous showed that gut-derived lipopolysaccharide (LPS) promote HCC development by activating Toll-like receptor 4 (TLR4) expressed on myeloid-derived cells. However, effects LPS other types liver injury models are yet to be studied. The purpose this study was determine importance TLR4 signaling T-cell-mediated hepatitis-Con A-induced hepatitis model,...
The activity of the serine/threonine kinase c-Raf (Raf) is inhibited by increased intracellular cAMP. This believed to require phosphorylation with cAMP-dependent protein (PKA), although mechanism which PKA inhibits Raf controversial. We investigated requirement for using mutants expressed in HEK293 or NIH 3T3 cells. Phosphopeptide mapping 32P-labeled (WT) a mutant lacking putative site (serine alanine, S43A) confirmed that serine 43 (Ser43) was major cAMP (forskolin)-stimulated vivo....
We have previously identified a human receptor protein tyrosine phosphatase of the MAM domain family, termed PCP-2, in pancreatic adenocarcinoma cells and found that this was colocalized with β-catenin E-cadherin at cell junctions [Wang, H.-Y., et al. (1996) Oncogene 12, 2555−2562]. Its intracellular part consists two tandem domains relatively large juxtamembrane region is homologous to conserved cadherins, suggesting role regulation adhesion. This study reports PCP-2 endogenously expressed...
Abstract Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and stands among leading causes cancer-related deaths. Although deregulation microbiota in gastrointestinal tract has been described CRC, very little known about precise molecular mechanisms by which bacteria their toxins modulate process tumorigenesis behavior cells. In this study, we produced recombinant Bacteroides fragilis enterotoxin-1 (rBFT1) demonstrate that rBFT1 could promote cell...
Tumor angiogenesis is a complex process that unamenable to intravital whole-process monitoring, especially on microscopic assessment of tumor microvessel and quantifying microvascular hemodynamics before after the nanotherapeutics, which hinder understanding nanotheranostics outcomes in treatment. Herein, new photoacoustic (PA) imaging-optical coherence tomography angiography (OCTA)-laser speckle (LS) multimodal imaging strategy first proposed, not only able precisely macro guide...
Background This study aimed at analyzing the prevalence of hepatitis B virus ( HBV ) DNA among surface antigen HB s A g)–negative donations by cobas T aq S creen MPX test R oche M olecular ystems) and discussing meaning a reactive minipool MP that does not resolve to an individual donation ID )–reactive result. Study Design Methods Nucleic acid amplification testing NAT was performed in 12 C hinese blood centers on 826,044 serologic negative six. ‐reactive pools were resolved confirmed viral...
Chemokine C‐C motif chemokine ligand 3 (CCL3) plays an important role in the invasion and metastasis of malignant tumors. For developing new therapeutic targets antitumor drugs, effect CCL3 related cytokine network on colorectal cancer should be investigated. This study used cell, tissue, animal experiments to prove that is highly expressed confirmed can promote proliferation cells, its expression closely TRAF6/NF‐ κ B molecular pathway. In addition, protein chip technology was examine...
Abstract Background: Chemokines and their receptors can be expressed on the surface of inflammatory cells malignant tumor in body. Tumor participate directional organ metastasis by means ‘navigation effect’ chemokines. Recent studies have found that chemokine C-C motif ligand 3 (CCL3) plays an important role invasion tumors. Determining effect CCL3 related cytokine network colorectal cancer is helpful developing new therapeutic targets anti-tumor drugs, as well improving survival rate...