A5100456698- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- RNA Research and Splicing
- Optimism, Hope, and Well-being
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Hormonal Regulation and Hypertension
- Hippo pathway signaling and YAP/TAZ
- melanin and skin pigmentation
- Analytical Chemistry and Sensors
- Acute Lymphoblastic Leukemia research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Electrochemical sensors and biosensors
- Psychological and Temporal Perspectives Research
- Kruppel-like factors research
- Child Abuse and Trauma
- Functional Brain Connectivity Studies
- Bullying, Victimization, and Aggression
- Cancer-related molecular mechanisms research
- Psychological Well-being and Life Satisfaction
- Microtubule and mitosis dynamics
Deyang Stomatological Hospital
2025
Shenzhen University
2022-2024
Peking University
2024
Peking University Cancer Hospital
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Shanghai Institute of Organic Chemistry
2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shandong University of Traditional Chinese Medicine
2023-2024
Social anxiety severely impacts adolescents' social interactions with others; however, the underlying neural mechanism has not been revealed. This study examined how adolescent's level influences interbrain synchrony within adolescent-parent dyads during emotional processing by using electroencephalograph (EEG) hyperscanning. A sample of 25 completed picture task. Adolescents' ages ranged from 10 to 14 years old. The results showed that (1) at parietal areas, greater gamma was observed in...
Background: ORIN1001, a first-in-class oral IRE1-α endoribonuclease inhibitor to block the activation of XBP1, is currently in clinical development for inhibiting tumor growth and enhancing effect chemical or targeted therapy. Early establishment population pharmacokinetic (PopPK) model could characterize pharmacokinetics (PK) ORIN1001 evaluate effects individual-specific factors on PK, which will facilitate future this investigational drug. Methods: Non-linear mixed was constructed by...
Individuals affected with glaucoma and cataracts are more likely to experience depressive symptoms, which can affect their overall quality of life (QOL) functioning. Therefore, this retrospective cohort study aimed evaluate the impact cognitive behavioral therapy (CBT) on or patients mild moderate depression. This included depression resulting from in our hospital January 2023 December 2023. The participants were divided into an untreated group a based different intervention methods. We...
This study examined loneliness and future orientation as predictors of suicidal risk, namely, depressive symptoms suicide ideation, in a sample 228 college students (54 males 174 females). Results regression analyses indicated that was significant predictor both indices risk. The inclusion found to significantly augment the prediction model even after accounting for loneliness. Noteworthy, beyond orientation, Loneliness × Future Orientation interaction term further models Consistent with...
Plaque accumulation and microbial community changes are important causes of periodontal disease. Cleaned plaque microorganisms will reattach to form biofilms, but the recovery outcome communities in different health states remain unknown. In this study, we tracked biofilm remodeling process 206 dental samples from 40 healthy periodontal, gingivitis periodontitis volunteers at 6 time points before after supragingival scaling. We found that changed asynchronously during process, more severe...
Abstract Oxysterol-binding protein like 3 (OSBPL3) has been shown involving in the development of several human cancers. However, relationship between OSBPL3 and colorectal cancer (CRC), particularly role proliferation, invasion metastasis CRC remains unclear. In this study, we investigated found that its expression was significantly higher tissues than normal tissues. addition, high closely related to poor differentiation, advanced TNM stage prognosis CRC. Further experiments showed...
Purpose: This study aims to investigate the biological effect and molecular mechanism of Lamin B1(LMNB1) in lung cancer cells its significance for prognosis adenocarcinoma(LUAD) patients. Methods: In this study, Bioinformatics was performed analyze expression at mRNA level LMNB1 LUAD from TCGA dataset. The immunohistochemistry(IHC) assay conducted analyzed protein tissues. correlation between clinical factors patients with analyzed. Next, transfected into cell lines (A549 PC-9) which proved...
TAB182 (also named TNKS1BP1), a binding protein of tankyrase 1, has been found to participate in DNA repair. Our previous study revealed the involvement radioresistance esophageal squamous cell carcinoma (ESCC) cells. However, whether contributes ESCC tumorigenesis and progression remains unclear. In this study, we that highly expressed is closely associated with poor prognosis patients ESCC. silencing reduced proliferation invasion vitro, tumorigenicity metastasis vivo. RNA-seq IP-MS...
Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting inconsistent clinical application efficacy. We hypothesized that subclones MSCs contribute to their tumorgenicity, and we approached MSC-subclones at the single-cell level. Methods: were cultured an osteogenic differentiation medium harvested on days 12, 19, 25 for cell analysis using Alizarin Red followed with transcriptome. Results: Single-cell RNA-seq reveals a...
In this work, a novel portable and wireless intelligent electrochemical nanosensor was developed for the detection of 6,7-dihydroxycoumarin (6,7-DHC) using modified screen-printed electrode (SPE). Black phosphorene (BP) nanosheets were prepared via exfoliation black phosphorus nanoplates. The BP then mixed with nano-diamond (ND) to prepare ND@BP nanocomposites self-assembly method, achieving high environmental stability. nanocomposite characterized by SEM, TEM, Raman, XPS XRD. used...
<i>Escherichia coli</i> O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in humans. The previous found a combination kojic acid and tea polyphenols exhibited better activity against <i>E. than using either alone. This study aimed to explore responses underlying antibacterial mechanisms from gene level. functional enrichment analysis by comparing individually or synergistically resistance systems were activated, cell membrane genomic DNA destructed...
BACKGROUND Kid (kinesin-like DNA binding protein), a member of microtubule-dependent molecular motor proteins, also known as KIF22, is reported to be associated with carcinogenesis and cancer progression in different types malignant tumor, but the biologic behavior clinical outcome KIF22 prostate (PCa) has not been well studied. This study aimed analyze association between PCa patients. MATERIAL AND METHODS The expression tumor specimens compared paired paracancerous tissue from 114 patients...
Abstract Background Radiotherapy is one of the main strategies for treatment esophageal squamous cell carcinoma (ESCC). However, failure often occurs due to emergence radioresistance. In this study, we report a key regulator radiation sensitivity, termed TAB182 that may become an ideal biomarker and therapeutic target overcome Materials Methods By applying qRT‐PCR immunohistochemical staining, expression was detected in patient tissues. We next assessed influence downregulation...
Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation through integrin αVβ3.We inhibited function αVβ3 cells by treating with c(RGDyk). Using cytochalasin D verteporfin inhibit polymerization microfilament nuclear Yes-associated protein (YAP), respectively. For each application, were loaded cyclic 10% at 0.5 Hz for 2 h daily. Mesenchymal...
The present study investigated loneliness and optimism as predictors of suicide risk, specifically, depressive symptoms suicidal ideation, in 457 Hungarian college students. Beyond the expected role being optimistic buffered positive association between suicide. findings implicate importance fostering for potentially lowering risk among lonely
Purpose . To compare the expression level of apelin in muscle-invasive bladder cancer and matched paracarcinoma tissues investigate relationship between clinical prognosis patients. Methods assess by using immunohistochemical method compared with tumors tissues. Subsequently, correlation clinicopathological features patients was analyzed. Kaplan-Meier survival curves used to analyze prognostic significance for (including 404 28 normal tissues, TCGA dataset). Results Apelin protein...
Background Lung adenocarcinoma (LUAD) is the most prevalent pathological subtype of lung cancer. Kinesin family member 18A (KIF18A) plays an important role in tumorigenesis. Its roles breast cancer, colorectal and other tumors have been demonstrated; however, studies KIF18A LUAD are limited. This study aimed to determine progression prognostic prediction. Methods expression was examined cells tissues by immunohistochemistry Western blotting. Cell proliferation assay performed cells....
Abstract Bioactive peptides pose a great threat to sports integrity. The detection of these is essential for enforcing their prohibition in sports. Identifying the catabolites that are formed ex vivo plasma may improve detection. In present study, stability 27 bioactive with protection at both termini equine was examined under different incubation conditions, using HILIC coupled HRMS. Of peptides, 13 were stable after 37°C 72 hr, but remaining 14 less stable. E x detected theoretical masses...
Radiotherapy resistance is an important and urgent challenge in the clinical management of esophageal squamous carcinoma (ESCC). However, factors mediating ESCC to radiotherapy its underlying molecular mechanisms are not fully clarified. Our previous studies have demonstrated critical role DNA polymerase iota (POLI) development progression, here, we aimed investigate involvement POLI elucidate mechanism. We found that highly expressed was correlated with shorter overall survival patients...
Aims and Background Fenofibrate is a specific agonist of PPARα, characterized by relatively low systemic toxicity. Recent studies have revealed that fenofibrate suppresses the growth several cancer lines in vitro, but exact relation between irradiation has not been explored. The purpose this study was to investigate radiosensitivity enhancement effects combined with radiation on human esophageal carcinoma cell Eca-109 TE1, potential mechanism underlying these effects. Methods Study design...
Dryland montane forests are important agents for soil and water resource conservation. The growth of these under climate warming is strongly affected by local environmental factors. However, how factors impact intra-annual stem dynamics across gradients in regions remains unclear. This work focused on assessing seasonal patterns different elevations the Qilian Mountains, northwestern China. 50 Qinghai spruce trees was monitored two years an elevation gradient from 2500 m to 3300 above sea...