A5054330701- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Nanotechnology research and applications
- Crystallization and Solubility Studies
- Cancer Immunotherapy and Biomarkers
- X-ray Diffraction in Crystallography
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
- Extracellular vesicles in disease
- Nanomaterials for catalytic reactions
- Carbon Nanotubes in Composites
- Air Quality and Health Impacts
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Polymer Surface Interaction Studies
- Metal complexes synthesis and properties
- Advanced Photocatalysis Techniques
- Per- and polyfluoroalkyl substances research
Nantong University
2016-2025
University of Chinese Academy of Sciences
2024-2025
Nantong Science and Technology Bureau
2018-2020
Shandong University
2009-2018
Nanjing University
2014-2018
St. Jude Children's Research Hospital
2009-2016
Nanomaterials Research (United States)
2013
University of Massachusetts Boston
2009
As an emerging applied material, graphene has shown tremendous application potential in many fields, including biomedicine. However, the biological behavior of these nanosheets, especially their interactions with cells, is not well understood. Here, we report our findings about cell surface adhesion, subcellular locations, and size-dependent uptake mechanisms protein-coated oxide nanosheets (PCGO). Small enter cells mainly through clathrin-mediated endocytosis, increase size enhances...
The outbreak of the pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for an urgent unmet need developing a facial and cost-effective detection method. requirement well-trained personnel sophisticated instrument current primary mean (reverse transcription polymerase chain reaction, RT-PCR) may hinder practical application worldwide. In this regard, reverse recombinase amplification (RT-RPA) coupled with CRISPR-Cas12a colorimetric assay is proposed...
Hydroxyphenol compounds are often used as reductants in controlling the growth of nanoparticles. Herein, dopamine was an effective reductant seed-mediated synthesis gold nanorods (GNRs). The as-prepared GNRs (83 × 16 nm) were monodisperse and had a high degree purity. conversion ratio from ions to around 80%. In addition, worked additive. At very low concentration hexadecyltrimethylammonium bromide (CTAB; 0.025 M), thinner shorter (60 9 successfully prepared. By regulating silver ions, CTAB,...
Physiochemical properties of engineered nanoparticles (NPs) play a vital role in nano-bio interactions, which are critical for nanotoxicity and nanomedicine research. To understand the effects NP hydrophobicity on formation protein corona, we synthesized four gold NPs with continuous change ranging from -2.6 to 2.4. Hydrophobic adsorbed 2.1-fold proteins compared hydrophilic ones. Proteins small molecular weights (<50 kDa) negatively charge (PI < 7) constituted majority especially...
On-site monitoring of trace organic pollutants with facile methods is critical to environmental pollutant prevention and control. Herein, we proposed a CRISPR-Cas12a-based aptasensor platform (named as MC-LR-Casor) for on-site sensitive detection microcystin-LR (MC-LR). After hybridization blocker DNA, the MC-LR aptamers were conjugated magnetic beads (MBs) get MB aptasensor. In presence MC-LR, their interactions triggered specific binding caused release DNA. Using programmability CRISPR-Cas...
We examine the origin of electrostatic attraction between nanoparticle (NP) and cells by synthesizing a NP array with continuous change in surface charge density (SCD). This does not show linear change, but sharp increase as positive SCD increases. The results zeta potential measurements naked protein bound NPs reveal that excessive charges on ligands are partially shielded, noncovalent bindings do influence NP–cell interactions. effective outmost layer determined
Protein corona can alter the physiochemical properties of targeting nanoparticles (NPs), as well their physiological responses and functionality. Herein, we synthesized 20 types NPs with diverse surface chemistry in order to study impacts protein on functionality functionalized cyclic RGD peptides relationships polyethylene glycol (PEG) length grafting density ligands. After adsorption, NP was still able bind its receptors increased targeted cellular uptake, even at a relatively low density....
Afatinib (Afa), a second-generation irreversible epidermal growth factor inhibitor for the development of non-small cell lung cancer, has low bioavailability and adverse reactions. Nanoscaled drug delivery systems offer promising alternatives to address these defects improve therapeutic outcomes. In present study, Tf contained, redox-sensitive ligand was synthesized used preparation afatinib loaded, modified lipid-polymer hybrid nanoparticles (Tf-SS-Afa-LPNs). Subsequently, studies...
Stimuli-responsive DNA-based nanostructures have emerged as promising vehicles for intelligent drug delivery. In this study, i-motif DNA-conjugated gold nanostars (GNSs) were fabricated in a facile manner stimuli-responsive delivery systems (denoted A-GNS/DNA/DOX) the treatment of cancer via combined chemo-photothermal therapy. The DNA is sensitive to environmental pH and can switch from single-stranded structure C-tetrad (i-motif) decreases neutral (∼7.4) acidic (<6.0). loaded then be...