A5011288538- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Graphene and Nanomaterials Applications
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Trace Elements in Health
- Anesthesia and Neurotoxicity Research
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Effects and risks of endocrine disrupting chemicals
- Nanoplatforms for cancer theranostics
- Per- and polyfluoroalkyl substances research
- Adipose Tissue and Metabolism
- Nanotechnology research and applications
- Forensic Toxicology and Drug Analysis
- Fluoride Effects and Removal
- Computational Drug Discovery Methods
- Carbon Nanotubes in Composites
Guangzhou University
2019-2024
Shandong University
2016-2023
University of New Mexico
2015
A theranostic prodrug for mechlorethamine has been developed photo-controlled release and monitoring by fluorescence spectroscopy.
Dioxins, mostly through activation of aryl hydrocarbon receptor (AhR), are potent toxic substances widely distributed in the environment, while moderated suppression AhR also exhibits anti-tumor effects. Therefore, proper modulation activity may counteract AhR-mediated toxicities and certain diseases. In this investigation, we identified several novel moderate agonists antagonists using chemical biology approaches. The mechanisms mode interactions with by these hits were revealed both...
Non-alcoholic fatty liver disease (NAFLD), mainly characterized by the accumulation of excess fat in hepatocytes, is most prevalent disorder afflicting ~25% adults worldwide. In vivo studies have shown that adult rodents with NAFLD were more sensitive to metallic nanoparticles (MNPs) than healthy MNPs. However, due complex interactions between various cell types a liver, it has become major challenge reveal toxic effects MNPs specific cells such as steatotic hepatocytes. this study, we...
Environmental carbon nanomaterials such as multi-walled nanotubes (MWCNTs) and graphene oxides (GOs) may interact with aromatic hydrocarbon pollutants, benzo[a]pyrene (BaP), in the environment, causing adverse effects on ecosystems human health. However, impact of joint toxicity BaP is still unknown. Among all six investigated, MWCNTs-NH2, p-GO, GO-COOH exhibited some alleviation BaP-induced cytotoxicity, while has most potent inhibitory effect cytotoxicity BaP. Mechanistically, alleviated...
Despite numerous studies on effects of environmental accumulation nano-pollutants, the influence nanoparticles biological perturbations coexisting pollutants in environment remained unknown. The present study aimed at elucidating six detoxification dioxin-induced toxicity cellular level. We discovered that there was no remarkable difference cell uptake and intracellular distributions these nanoparticles. However, they have different dioxin TCDD. Multi-walled carbon nanotube s(MWCNTs)...