A5000095180- Photonic and Optical Devices
- Optical Network Technologies
- Neural Networks and Reservoir Computing
- Gut microbiota and health
- Corporate Finance and Governance
- Advanced Photonic Communication Systems
- Inflammatory Bowel Disease
- Cavitation Phenomena in Pumps
- Fiscal Policy and Economic Growth
- Semiconductor Lasers and Optical Devices
- Erythrocyte Function and Pathophysiology
- Gastrointestinal motility and disorders
- Photonic Crystals and Applications
- Clostridium difficile and Clostridium perfringens research
- Global trade and economics
- Advanced Fiber Laser Technologies
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Zebrafish Biomedical Research Applications
- Globalization, Economics, and Policies
- Laser and Thermal Forming Techniques
- Atomic and Subatomic Physics Research
- China's Socioeconomic Reforms and Governance
- International Business and FDI
- Silicon Nanostructures and Photoluminescence
University of Cambridge
2021-2025
University of Nottingham
2007-2024
Ningxia Medical University
2022-2024
Center for Excellence in Brain Science and Intelligence Technology
2018-2024
Chinese Academy of Sciences
2018-2024
Daping Hospital
2016-2023
Army Medical University
2016-2023
Xi'an University of Technology
2020-2022
University of Chinese Academy of Sciences
2019-2021
Institute of Semiconductors
2021
Autism spectrum disorder (ASD) is a severe brain development that characterized by deficits in social communication and restricted, repetitive stereotyped behaviors. Accumulating evidence has suggested gut microbiota disorders play important roles gastrointestinal symptoms neurodevelopmental dysfunction ASD patients. Manipulation of the fecal transplantation (FMT) was recently shown to be promising therapy for treatment various diseases. Here, we performed clinical trial evaluate effect FMT...
Miniaturization of optical spectrometers is important to enable spectroscopic analysis play a role in situ, or even vitro and vivo characterization systems. However, scaled-down generally exhibit strong trade-off between spectral resolution operating bandwidth, are often engineered identify signature peaks only for specific applications. In this paper, we propose demonstrate novel global sampling strategy with distributed filters generating ultra-broadband pseudo-random responses. The...
The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related gut dysbiosis, however, the impact fecal microbiota transplantation (FMT) on engraftment in PD patients is uncertain. We performed a randomized, placebo-controlled trial at Department Neurology, Army Medical University Southwest Hospital China (ChiCTR1900021405) from February 2019 December 2019. Fifty-six participants with mild moderate (Hoehn-Yahr stage 1–3) were randomly assigned FMT placebo...
Optical spectroscopic sensors are a powerful tool to reveal light-matter interactions in many fields. Miniaturizing the currently bulky spectrometers has become imperative for wide range of applications that demand situ or even vitro characterization systems, field is growing rapidly. In this paper, we propose novel integrated reconstructive spectrometer with programmable photonic circuits by simply using few engineered MZI elements. This design effectively creates an exponentially scalable...
Abstract The fruits of China's rapid economic development over the 3 decades have not been distributed fairly across different regions. Using data from a sample 815 Chinese listed firms during 1998—2004, our error‐correction investment model showes evidence financial constraints on firms' in We argue that regional policies contributed greatly to inequalities. To control rising inequality, China has shifted its focus coast interior However, it is becoming increasingly difficult for government...
The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate transplanted BMSCs in wounds weaken their potential application.To identify optimal protocol preconditioned with H2O2 improve efficacy using H2O2-preconditioned healing.Mouse were exposed to various concentrations H2O2, key cellular functional properties assessed determine precondition H2O2. into mice...
The pathogenesis of ulcerative colitis (UC) is unclear, but it generally believed to be closely related an imbalance in gut microbiota. Roseburia intestinalis (R. intestinalis) might play a key role suppressing intestinal inflammation, the mechanism its anti-inflammatory effect unknown. In this study, we investigated R. and Toll-like receptor 5 (TLR5) relieving mouse colitis. We found that significantly upregulated transcription TLR5 epithelial cells (IECs) improved colonic inflammation...
We present two spatial-multiplexed switch-and-select (S&S) 8x8 optical switches incorporating a tri-layer SiN-on-Si platform, one equipped with thermo-optic (T-O) and the other electro-optic (E-O) switching elements. To best of our knowledge, switch fabric is first-of-its-kind device assembled in such multi-layer platform. The shuffle between multiplexer demultiplexer array established via Si-SiN-SiN structure, creating three-dimensional crossing-free photonic network. At same time,...
Abstract Photonic neural networks (PNNs) are fast in-propagation and high bandwidth paradigms that aim to popularize reproducible NN acceleration with higher efficiency lower cost. However, the training of PNN is known be challenging, where device-to-device system-to-system variations create imperfect knowledge PNN. Despite backpropagation (BP)-based algorithms being industry standard for their robustness, generality, gradient convergence digital training, existing PNN-BP methods rely...
Background The interaction between the host and microbiota is influenced by circadian rhythm. However, it unknown what changes of gut metabolites. Methods We conducted a cross-sectional study (n=72) in which participants’ fecal DNA was detected macrogenomic sequencing analysis. feces, urine blood were analyzed widely targeted metabolomics Results Pearson correlation analysis showed that most clinical symptoms people with rhythm disorders moderately positively correlated gastrointestinal...
Curcumin has exhibited a protective effect against development of renal fibrosis in animal models, however, its underlying molecular mechanisms are largely unclear. Therefore, we investigated the anti-fibrosis effects curcumin transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT), and mechanism by which it mediates phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Human kidney tubular epithelial cells (HKCs) were treated with TGF-β1 or alone, combination...
The identification of ulcerative colitis (UC) and Crohn's disease (CD) is a key element interfering with therapeutic response, but it often difficult for less experienced endoscopists to identify UC CD. Therefore, we aimed develop validate deep learning diagnostic system trained on large number colonoscopy images distinguish CD.This multicenter, study was performed in 5 hospitals China. Normal individuals active patients inflammatory bowel (IBD) were enrolled. A dataset 1,772 participants...
Patients suffering from major trauma often experience complications such as sepsis. The early recognition of patients at high risk sepsis after is critical for precision therapy. We aimed to derive and validate a novel predictive score using electronic medical record (EMR) data following trauma. Clinical laboratory variables 684 within 24 h admission were collected, including 411 in the training cohort 273 validation cohort. least absolute shrinkage selection operator (LASSO) technique was...
Two series of peptides that specifically bind to the extracellular domain α chain human interleukin-5 receptor (IL-5Rα), but share no primary sequence homology IL-5, were identified from libraries random recombinant peptides. Affinity maturation procedures generated a 19-aa peptide binds IL-5 α/β heterodimer complex with an affinity equal and is potent specific antagonist activity in eosinophil adhesion assay. The active form disulfide-crosslinked dimer forms spontaneously solution. Gel...
Abstract The retinotectal synapse in larval zebrafish, combined with live time-lapse imaging, provides an advantageous model for study of the development and remodelling central synapses vivo . In previous studies, these were labelled by transient expression fluorescence-tagged synaptic proteins, which resulted dramatic variation labelling patterns each larva. Here, using GAL4-Upstream Activating Sequence (GAL4-UAS) methodology, we generated stable transgenic lines, express EGFP-tagged...