Ling Fan

ORCID: 0000-0003-2276-4899
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Research Areas
  • Health disparities and outcomes
  • Geophysical Methods and Applications
  • Microbial Applications in Construction Materials
  • Pelvic floor disorders treatments
  • Geophysical and Geoelectrical Methods
  • Cancer Cells and Metastasis
  • Gastric Cancer Management and Outcomes
  • Innovative concrete reinforcement materials
  • Global Maternal and Child Health
  • Concrete and Cement Materials Research
  • Gastrointestinal motility and disorders
  • Helicobacter pylori-related gastroenterology studies
  • Mesenchymal stem cell research
  • Grouting, Rheology, and Soil Mechanics
  • Demographic Trends and Gender Preferences
  • Health and Wellbeing Research
  • Sex and Gender in Healthcare
  • Cervical and Thoracic Myelopathy
  • Intergenerational Family Dynamics and Caregiving
  • Galectins and Cancer Biology
  • Congenital gastrointestinal and neural anomalies
  • Nuclear Structure and Function
  • Mental Health Research Topics
  • Veterinary medicine and infectious diseases
  • Neurogenetic and Muscular Disorders Research

Central South University
2021-2024

First People's Hospital of Chongqing
2018-2023

Army Medical University
2017-2022

Daping Hospital
2017-2022

Dalian Medical University
2021-2022

Chongqing Medical University
2021-2022

Second Affiliated Hospital of Chongqing Medical University
2021-2022

Chinese University of Hong Kong, Shenzhen
2022

The Ohio State University
2009-2021

Hunan Nonferrous Metal Research Institute
2021

OBJECTIVES: This study assessed the effectiveness, adverse events, patient adherence, and costs of modified dual therapy compared with bismuth-containing quadruple for treating Helicobacter pylori infection in Chinese patients. We also sought to determine whether could be used as an alternative first-line treatment H. infection. METHODS: A total 232 pylori- infected , treatment-naive patients were enrolled this open-label, randomized controlled clinical trial. Patients randomly allocated...

10.14309/ajg.0000000000000132 article EN The American Journal of Gastroenterology 2019-02-25

Chemotherapy can induce premature ovarian insufficiency (POI). POI causes multiple sequelae and is currently incurable. As shown in our previous studies, systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) home to ovaries with chemotherapy-induced subsequently reduce injury improve function rats POI. However, the cellular mechanisms that direct migration homing of hAD-MSCs are incompletely understood. This study investigated role SDF-1/CXCR4 axis its relevant...

10.1186/s13287-022-02759-6 article EN cc-by Stem Cell Research & Therapy 2022-02-23

Background To investigate the serotypes, antibiotic susceptibilities, and multi-locus sequence type (MLST) profiles of Streptococcus agalactiae (S. agalactiae) in Beijing to provide references for prevention treatment S. infections. Methods All isolates were identified using CAMP test latex-agglutination assay serotyped a Strep-B-Latex kit, after which they assessed susceptibility, macrolide-resistance genes, MLST profiles. Results In total, 56 863 pregnant women (6.5%). Serotypes Ia, Ib,...

10.1371/journal.pone.0120035 article EN cc-by PLoS ONE 2015-03-17

// Xingwei Wang 1, 2 , Yan Cao 1 Shirong Zhang Zhihui Chen Ling Fan Xiaochun Shen Shiwen Zhou and Dongfeng Department of Gastroenterology, The Third Affiliated Hospital, Military Medical University, Chongqing 400042, China Base for Drug Clinical Trial, Second 400037, Correspondence to: Chen, email: wxwwxw2011@126.com Keywords: esophageal cancer, cancer stem cells, CXCL12, CXCR4, metastasis Received: August 02, 2016 Accepted: December 01, Published: February 10, 2017 ABSTRACT Esophageal is...

10.18632/oncotarget.15254 article EN Oncotarget 2017-02-10

The identification of ulcerative colitis (UC) and Crohn's disease (CD) is a key element interfering with therapeutic response, but it often difficult for less experienced endoscopists to identify UC CD. Therefore, we aimed develop validate deep learning diagnostic system trained on large number colonoscopy images distinguish CD.This multicenter, study was performed in 5 hospitals China. Normal individuals active patients inflammatory bowel (IBD) were enrolled. A dataset 1,772 participants...

10.3389/fmed.2022.854677 article EN cc-by Frontiers in Medicine 2022-03-18

We assessed parental perceptions of benefits and risks pediatric antidepressant use relative to another common treatment option, psychotherapy. also explored sociodemographic variables that might influence these perceptions.A total 501 caregivers children presenting community mental health centers completed a questionnaire assessing demographic characteristics, history, attitudes toward psychotherapy medications.Counseling was perceived as beneficial having few risks, whereas medications...

10.1089/cap.2008.0129 article EN Journal of Child and Adolescent Psychopharmacology 2009-06-01

The purpose of this research is to identify the bowel symptoms and self-care strategies for rectal cancer survivors during recovery process following low anterior resection surgery. A total 100 participants were investigated under structured interview guide based on dimensions "symptom management theory". 92% reported changes in habits, most common being frequent movements narrower stools, which we named it finger-shaped consistency stools. 6 frequently excessive flatus (93%), clustering...

10.1186/s12893-018-0368-5 article EN cc-by BMC Surgery 2018-06-04

To investigate the physical and psychological effects of five-element music therapy combined with Baduanjin qigong treatment on inpatients mild coronavirus disease 2019 (COVID-19) in Wuhan.A mixed-methods study was used. In quantitative study, a randomized controlled trial performed 40 participants divided into control group (n = 20) an intervention 20). The Self-rating Anxiety Scale, Depression Scale Pittsburgh Sleep Quality Index were compared. For qualitative analysis, it adopted...

10.1177/15691861231167536 article EN cc-by-nc Hong Kong Journal of Occupational Therapy 2023-04-12

To make three-dimensional electromagnetic exploration achievable, the distributed wide field electro- magnetic method (WFEM) based on high-order 2n sequence pseudo-random signal is proposed and realized. In this method, only one set of waveforms, which contains all target frequencies, needed. Based construction algorithm, waveform can be customized according to different tasks. And receivers are independent with each other dynamically adjust acquisition parameters requirements. A test in...

10.1016/s1003-6326(22)65897-7 article EN Transactions of Nonferrous Metals Society of China 2022-05-01

The appearance of cracks is one the reasons that affect performance asphalt pavement, and traditional repair methods have potential problem causing adverse effects on environment. In this paper, an environmentally friendly method for concrete crack was investigated using microbially induced calcite precipitation (MICP) different widths (0.5 mm, 1.0 1.5 3 mm), effectiveness evaluated nondestructive destructive experiments. A varied ultrasonic pulse velocity used to evaluate healing process,...

10.3390/ma16093576 article EN Materials 2023-05-07

Abstract Background Constipation is a frequent adverse drug event seen with opioids, the first‐line therapy for sickle cell pain crises. Proactive use of laxatives and stool softeners recommended when opioids are prescribed. Our objective was to generate national estimates inpatient during opioid administration in children disease (SCD) identify associations between individual hospital‐level factors laxative prescription. Procedure We analyzed data from 29 children's hospitals Pediatric...

10.1002/pbc.22395 article EN Pediatric Blood & Cancer 2010-01-04

Clarithromycin-resistance is becoming a global health concern in the treatment of Helicobacter pylori (H. pylori). The mutant prevention concentration (MPC) represent propensities antimicrobial agents to select resistant mutants. range between minimum inhibitory (MIC) and MPC defined as selection window (MSW). In this study, we aimed determine cause increasing clarithromycin resistance by investigating MSW for clinical isolates H. pylori. A retrospective subgroup, which included 68...

10.1186/s12866-019-1558-8 article EN cc-by BMC Microbiology 2019-08-05

Hot dry rock (HDR) is a geothermal resource with high temperature that widely distributed and has good potential as clean renewable energy source. To determine underground electrical structures to predict granite reservoir distributions, the wide-field electromagnetic (WFEM) method been applied explore deep mineral resources advantages such explorations at greater depths resolutions. In this study, WFEM investigation was carried out for HDR exploration in Gonghe Basin within Qinghai...

10.3390/min11101105 article EN Minerals 2021-10-09

This study aimed to evaluate the expression characteristics of lamin A/C proteins in intervertebral disc degeneration (IVD) specimens from patients with different grades. Lamin have been shown result age-related changes osteoarticular system. However, these nuclear degenerated human IVD tissues not explored previously.Degenerated were obtained during spinal surgery. Articular cartilage samples after total knee replacement surgery used as controls. Sections stained hematoxylin and eosin,...

10.26355/eurrev_201811_16374 article EN PubMed 2018-11-01

Cracks are a major factor affecting the durability of asphalt concrete. Microbial-induced calcite precipitation (MICP) represents an eco-friendly method for repairing these cracks compared to conventional methods. This study investigates repair artificial prefabricated concrete using MICP, assessing uniaxial compressive strength, permanent deformation, moisture buffering, and water sensitivity different crack depth conditions. Microscopic analysis SEM/EDS X-ray micro-computed tomography was...

10.1080/10298436.2024.2430751 article EN International Journal of Pavement Engineering 2024-11-20

Cracks are one of the major diseases asphalt concrete. Microbial induced calcite precipitation(MICP) is environment-friend technique for crack repair, compared with conventional repair methods which have adverse environmental risk. The artificial prefabricated concrete cracks experimentally investigated using MICP. performances MICP involving uniaxial compressive strength (UCS), permanent deformation, moisture buffer and water sensitivity, assessed in consideration depth. Furthermore, their...

10.2139/ssrn.4370901 article EN 2023-01-01

A bandpass sigma-delta modulator with the function of adjustable center-frequency is present in this paper. method used to convert 2-order low-pass 4-order proposed realize design. Center-frequency that can be set 1/6, 1/4 and 1/3 sampling frequency controlled according digital logic voltage. The bandwidth pass-band 200 Hz. Test results show average SNR about 80 dB at different when 64 kHz. input signal reach −3 dBFs. complexity design a variable greatly reduced.

10.1142/s0217984918501403 article EN Modern Physics Letters B 2018-04-12
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