A5085546073- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Land Use and Ecosystem Services
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Soil Carbon and Nitrogen Dynamics
- Glutathione Transferases and Polymorphisms
- Cancer Treatment and Pharmacology
- Acute Myeloid Leukemia Research
- Coastal wetland ecosystem dynamics
- Genomics, phytochemicals, and oxidative stress
- Protein Degradation and Inhibitors
- Colorectal Cancer Treatments and Studies
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Mesenchymal stem cell research
- Multiple and Secondary Primary Cancers
- Autophagy in Disease and Therapy
- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Sun Yat-sen University
2019-2025
Nanjing Medical University
2008-2025
First Affiliated Hospital of Zhengzhou University
2024
Ministry of Ecology and Environment
2023-2024
Center for Life Sciences
2024
Tsinghua University
2024
Xiangya Hospital Central South University
2024
Central South University
2024
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
New treatments have improved outcomes for patients with relapsed chronic lymphocytic leukemia (CLL), but complete remissions remain uncommon. Venetoclax has a distinct mechanism of action; it targets BCL2, protein central to the survival CLL cells.
We present a phase II, single-arm study evaluating 800 mg daily venetoclax, highly selective, oral small-molecule B-cell leukemia/lymphoma-2 (BCL2) inhibitor in patients with high-risk relapsed/refractory acute myelogenous leukemia (AML) or unfit for intensive chemotherapy. Responses were evaluated following revised International Working Group (IWG) criteria. The overall response rate was 19%; an additional 19% of demonstrated antileukemic activity not meeting IWG criteria (partial bone...
Purpose B-cell leukemia/lymphoma-2 (BCL-2) overexpression is common in many non-Hodgkin lymphoma (NHL) subtypes. A phase I trial patients with NHL was conducted to determine safety, pharmacokinetics, and efficacy of venetoclax, a selective, potent, orally bioavailable BCL-2 inhibitor. Patients Methods total 106 relapsed or refractory received venetoclax once daily until progressive disease unacceptable toxicity at target doses from 200 1,200 mg dose-escalation safety expansion cohorts....
In efficacy trials of a tetravalent dengue vaccine (CYD-TDV), excess hospitalizations for were observed among recipients 2 to 5 years age. Precise risk estimates according serostatus could not be ascertained because the limited numbers samples collected at baseline. We developed anti–nonstructural protein 1 (NS1) IgG enzyme-linked immunosorbent assay and used from month 13 infer post hoc analysis safety efficacy.
ER-phagy keeps cells healthy In eukaryotic cells, about one-third of all proteins are targeted to the endoplasmic reticulum (ER), which serves as a hub for secretory protein traffic and quality control. Cui et al. studied known Lst1 in yeast SEC24C mammalian that is involved loading cargo into vesicles delivered Golgi complex. response stress caused by starvation or misfolded aggregate-prone proteins, acted promote an additional function—ER-phagy. Together with autophagy receptors on ER, ER...
The alternations in soil physicochemical properties caused by the reclamation of coastal tidal land can strongly affect activities extracellular enzymes. Soil enzymes are one most active organic components ecosystem, which is involved almost all biochemical reactions. Determining importance potential influencing factors and thus estimating their important for clarifying biological mechanism carbon nitrogen cycling. In this study, multiple linear regressions (MLR) random forest (RF) models...
Endoplasmic Reticulum (ER)-derived COPII coated vesicles constitutively transport secretory cargo to the Golgi. However, during starvation-induced stress, have been implicated as a membrane source for autophagosomes, distinct organelles that engulf cellular components degradation by macroautophagy (hereafter called autophagy). How cells regulate core trafficking machinery fulfill dramatically different roles in response environmental cues is unknown. Here we show phosphorylation of conserved...
8522 Background: The anti-apoptotic protein Bcl-2 is a highly expressed in NHL and contributes to chemotherapy resistance. ABT-199 selective, orally bioavailable, small molecule inhibitor that promising agent for the treatment of patients (pts) with NHL. Methods: Objectives this Phase I, dose-escalation study include evaluations safety, pharmacokinetics (PK), preliminary efficacy pts R/R was given on Week 1 Day -7 (W1D-7), followed by continuous, once-daily dosing from W1D1 until progressive...
Chemotherapeutic drug resistance remains a major obstacle to the successful treatment of colon cancer. Here, we show that 77 differentially expressed miRNAs were identified in SW1116/HCPT versus SW1116, and over-expressed miR-506 cells was validated. Then it indicated PPARα is common target by using luciferase reporter assay. Our results also demonstrated cytotoxic ability HCPT requires concomitant presence PPARα, loss expression imparts HCPTs anti-tumor effects. All together, our studies...
Urbanization, and the resulting land use/cover change, is a primary cause of degradation coastal wetland ecosystems. Reclamation projects are seen as way to strike balance between socioeconomic development maintenance Our aim was understand ecological changes Jiangsu’s from use change since 1977 by using remote sensing spatial analyses. The results indicate that: (1) area artificial expanded while natural reduced, which emphasized an increase in production-orientated uses at expense...
Abstract Background To explore the mechanism of different clinical efficacies mesenchymal stem cell transplantation (MSCT) and identify a possible serum biomarker for predicting therapeutic effect MSCT in rheumatoid arthritis (RA) patients. Methods A total 105 patients with persistently active RA poor responses to traditional medication were randomly divided into control groups. Outcomes evaluated according 28-joint Disease Activity Score Health Assessment Questionnaire, serological...