A5100369003- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Vestibular and auditory disorders
- Terahertz technology and applications
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Hearing, Cochlea, Tinnitus, Genetics
- Photonic and Optical Devices
- Hearing Loss and Rehabilitation
- Infant Health and Development
- Advanced Combustion Engine Technologies
- Anesthesia and Neurotoxicity Research
- Family and Disability Support Research
- Analytical chemistry methods development
- Epigenetics and DNA Methylation
- Intensive Care Unit Cognitive Disorders
- Agriculture Sustainability and Environmental Impact
- Neuroinflammation and Neurodegeneration Mechanisms
- Lanthanide and Transition Metal Complexes
- Machine Fault Diagnosis Techniques
- Adolescent and Pediatric Healthcare
- Spectroscopy and Laser Applications
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- Gastrointestinal motility and disorders
Shandong Provincial Hospital
2019-2023
Shandong First Medical University
2023
Qilu Hospital of Shandong University
2019-2022
Second Hospital of Shandong University
2022
Daping Hospital
2021
Army Medical University
2021
Shandong University
2007-2019
State Key Laboratory of Animal Nutrition
2019
China Agricultural University
2019
Harvard University
2016
Abstract The gut microbiome plays an important role in immune function and has been implicated several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the subjects with multiple sclerosis (MS, n =60) healthy controls ( =43). Microbiome alterations MS include increases Methanobrevibacter Akkermansia decreases Butyricimonas , correlate variations expression of genes involved dendritic cell maturation, interferon signalling NF-kB pathways circulating T cells monocytes....
Autism spectrum disorder (ASD) is a severe brain development that characterized by deficits in social communication and restricted, repetitive stereotyped behaviors. Accumulating evidence has suggested gut microbiota disorders play important roles gastrointestinal symptoms neurodevelopmental dysfunction ASD patients. Manipulation of the fecal transplantation (FMT) was recently shown to be promising therapy for treatment various diseases. Here, we performed clinical trial evaluate effect FMT...
Variation of maternal gut microbiota may increase the risk autism spectrum disorders (ASDs) in offspring. Animal studies have indicated that is related to neurodevelopmental abnormalities mouse offspring, while it unclear whether there a correlation between ASD children and their mothers. We examined relationships microbiome profiles those mothers, evaluated clinical discriminatory power discovered bacterial biomarkers. Gut was profiled by 16S ribosomal RNA gene sequencing stool samples 59...
The gut microbiota plays a critical role in various physiologic processes; however, maternal microbial and metabolic changes during pregnancy lactation remain elusive. Using pigs as an animal model, we conducted comparative analyses of short-chain fatty acid (SCFA) profiles across different stages gestation, lactation, the empty (nonpregnancy) phase 2 distinct breeds sow, Rongchang (RS) Landrace (LS). Coriobacteriaceae were found to gradually increase over gestational time irrespective...
KTiOPO₄ (KTP) crystal is used as the nonlinear medium in a surface-emitted terahertz-wave parametric oscillator for first time. The oscillating Stokes beam propagates along x axis of KTP crystal, pumping with small incident angle θ(ext) to axis, and polarizations beam, THz wave are z axis. When changed from 1.250° 6.000°, intermittently tuned 3.17 3.44 THz, 4.19 5.19 5.55 6.13 THz. maximum output 336 nJ, obtained at 5.72 energy 80 mJ. two frequency gaps, located vicinities A₁ modes 134 178.7...
Abstract Background The early-life microbiota exerts a profound and lifelong impact on host health. Longitudinal studies in humans have been informative but are mostly based the analysis of fecal samples cannot shed direct light early development mucosa-associated intestinal its GI function. Using piglets as model for human infants, we assess here succession across tract first 35 days after birth. Results Although sharing similar composition predicted functional profile at birth, microbiome...
Recent studies suggest that the interaction between presbycusis and cognitive impairment may be partially explained by cognitive-ear link. However, underlying neurophysiological mechanisms remain largely unknown. In this study, we combined magnetic resonance spectroscopy (MRS) resting-state functional imaging (fMRI) to investigate auditory gamma-aminobutyric acid (GABA) glutamate (Glu) levels, intra- inter-network connectivity, their relationships with function in 51 patients well-matched...
A MgO:LiNbO₃ slab configuration for the surface-emitted terahertz-wave parametric oscillator (TPO) is presented. The pump and oscillating Stokes beams were totally reflected at surface propagated zigzaggedly in crystal. Up to five terahertz emitted perpendicularly of total output energy THz-wave was 3.56 times as large that obtained from conventional TPO same experimental conditions. intensity distributions THz wave measured, they unsymmetrical horizontal direction while symmetrical vertical...
Microglia-mediated inflammation is associated with perioperative neurocognitive disorders (PNDs) caused by sevoflurane. Dexmedetomidine has been reported to protect against sevoflurane-induced cognitive impairment. In this study, we investigated the effects and underlying mechanisms of dexmedetomidine on microglial neuroinflammation PNDs.
Knock is one of the major constraints to improve performance and thermal efficiency spark ignition (SI) engines. It can also result in severe permanent engine damage under certain operating conditions. Based on ensemble empirical mode decomposition (EEMD), this paper proposes a new approach determine knock characteristics SI By adding uniformly distributed finite white Gaussian noise, EEMD preserve signal continuity different scales therefore alleviates mode-mixing problem occurring classic...
Motivation: The increasing evidence suggests a connection between presbycusis and cognitive impairment, yet the neurochemical mechanisms remain largely unexplored. Goal(s): To compare auditory cortex metabolite levels brain functional connectivity strength patients healthy controls, explore their potential associations with function hearing. Approach: We used Magnetic Resonance Spectroscopy (MRS) resting-state Imaging (rs-fMRI). Results: found reduced GABA in (AC), decreased AC ACC...