A5101586865- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Covalent Organic Framework Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Photocatalysis Techniques
- Aquaculture disease management and microbiota
- Pneumonia and Respiratory Infections
- vaccines and immunoinformatics approaches
- Electrochemical Analysis and Applications
- Bacterial Infections and Vaccines
- Advanced battery technologies research
- Antibiotic Resistance in Bacteria
- Electrocatalysts for Energy Conversion
- Indoor Air Quality and Microbial Exposure
- Identification and Quantification in Food
- Optical Systems and Laser Technology
- Epigenetics and DNA Methylation
- Vibrio bacteria research studies
- Bacillus and Francisella bacterial research
- CRISPR and Genetic Engineering
- Pharmacological Effects of Natural Compounds
- Advanced Optical Sensing Technologies
- Microbial Metabolic Engineering and Bioproduction
Sun Yat-sen University
2010-2024
Xinjiang Normal University
2022-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021-2024
Qingdao National Laboratory for Marine Science and Technology
2021-2024
ZheJiang Institute For Food and Drug Control
2021-2024
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Hainan Eye Hospital
2018-2022
Kyung Hee University
2021-2022
University of Chinese Academy of Sciences
2022
The construction of high-activity and low-cost electrocatalysts is critical for efficient hydrogen production by water electrolysis. Herein, we developed an advanced electrocatalyst anchoring well-dispersed Ir nanoparticles on nickel metal-organic framework (MOF) Ni-NDC (NDC: 2,6-naphthalenedicarboxylic) nanosheets. Benefiting from the strong synergy between MOF through interfacial Ni-O-Ir bonds, synthesized Ir@Ni-NDC showed exceptional electrocatalytic performance evolution reaction (HER),...
Francisella tularensis is a gram-negative pathogen that causes life-threatening infections in humans and has potential for use as biological weapon. The genetic basis of the F. virulence poorly understood. This study screened total 3,936 transposon mutants live vaccine strain infection mouse model respiratory tularemia by signature-tagged mutagenesis. We identified 341 attenuated lungs. disruptions were mapped to 95 different genes, virtually all which are also present genomes other strains,...
Variation of maternal gut microbiota may increase the risk autism spectrum disorders (ASDs) in offspring. Animal studies have indicated that is related to neurodevelopmental abnormalities mouse offspring, while it unclear whether there a correlation between ASD children and their mothers. We examined relationships microbiome profiles those mothers, evaluated clinical discriminatory power discovered bacterial biomarkers. Gut was profiled by 16S ribosomal RNA gene sequencing stool samples 59...
Abstract The construction of high‐activity and low‐cost electrocatalysts is critical for efficient hydrogen production by water electrolysis. Herein, we developed an advanced electrocatalyst anchoring well‐dispersed Ir nanoparticles on nickel metal‐organic framework (MOF) Ni‐NDC (NDC: 2,6‐naphthalenedicarboxylic) nanosheets. Benefiting from the strong synergy between MOF through interfacial Ni−O−Ir bonds, synthesized Ir@Ni‐NDC showed exceptional electrocatalytic performance evolution...
Abstract A MOF‐on‐MOF heterostructure is attractive in material science because of its potential combined effects catalysis. However, precisely controlling the growth pattern at metal–organic framework (MOF) nucleation stage to manipulate metallic composition and structure dimensionality remain a challenge. Herein, we introduce polyvinylpyrrolidone‐assist kinetic‐control strategy achieve “anti‐epitaxial growth” foreign MOF nucleus on (111) facets UiO‐66‐NH 2 octahedron seeds, construct...
Crucial metabolites that modulate hosts' metabolome to eliminate bacterial pathogens have been documented, but the metabolic mechanisms are largely unknown. The present study explores mechanism for l-leucine-induced Streptococcus iniae in tilapia. GC-MS-based metabolomics was used investigate tilapia liver profile presence of exogenous l-leucine. Thirty-seven differential abundance were determined, and 11 pathways enriched. Pattern recognition analysis identified serine proline as crucial...
Summary The development of antibiotic resistance in Vibrio alginolyticus represents a threat to human health and fish farming. Environmental NaCl regulation bacterial physiology is well documented, but whether the contributes remains unknown. To explore this, we compared minimum inhibitory concentration (MIC) V. cultured different media with 0.5%–10% NaCl, found that MIC increased as increased, especially for aminoglycoside antibiotics. Consistent this finding, internal also while...
Sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) functions as a unique redox-driven sodium pump, generating membrane potential, which is related to aminoglycoside antibiotic resistance. However, whether it modulates other metabolisms confer resistance unknown. The present study showed that loss of nqrA or nqrF led differential metabolomes with elevated antibiotics. Decreased alanine, aspartate, and glutamate metabolism depressed abundance alanine were characterized the most...
Background Ear infection or otitis media (OM) accounts for most bacterial respiratory infections in children both developed and developing nations. Streptococcus pneumoniae, nontypeable Haemophilus influenzae, Moraxella catarrhalis are the major OM pathogens. However, little is known about genetic basis of largely due to practical difficulties conducting research ear models genetically manipulating clinical isolates. Here, we report first genome-scale vivo screen genes required a chinchilla...
The advent of high-throughput sequencing methods allowed researchers to fully characterize microbial community in environmental samples, which is crucial better understand their health effects upon exposures. In our study, we investigated bacterial and fungal indoor outdoor air nine classrooms three elementary schools Seoul, Korea. extracted 16S rRNA gene ITS regions were sequenced, taxa identified. Quantitative polymerase chain reaction for total bacteria DNA was also performed. richer than...
(the pneumococcus) is a naturally competent organism that causes diseases such as pneumonia, otitis media, and bacteremia. The essential bacterial second messenger cyclic di-AMP (c-di-AMP) an emerging player in the stress responses of many pathogens. In
Streptococcus pneumoniae is a major pathogen causing bacterial infection in the middle ear of humans. We previously used S. strain ST556, low-passage 19F isolate from an otitis media patient, to perform whole-genome screen for infection-associated genes chinchilla model. This report presents complete genome sequence ST556. The will provide information complementary experimental data our genetic study this strain.
Pseudomonas aeruginosa is a Gram-negative γ-proteobacterium that forms part of the normal human microbiota and it also an opportunistic pathogen, responsible for 30% all nosocomial urinary tract infections. P. carries highly branched respiratory chain allows colonization many environments, such as tract, catheters other medical devices. contains three different NADH dehydrogenases (complex I, NQR NDH-2), whose physiologic roles have not been elucidated, up to five terminal oxidases:...
Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated proteins (Cas) provide bacteria archaea with adaptive immunity to specific DNA invaders. Mycobacterium tuberculosis encodes a type III CRISPR-Cas system that has not been experimentally explored. In this study, we found systems of both M. bovis BCG were highly upregulated by deletion Rv2837c (cnpB), which multifunctional protein hydrolyzes cyclic di-AMP (c-di-AMP), di-GMP (c-di-GMP), nanoRNAs (short...
Photochemical CO2 conversion into carbon fuel is a promising route to explore renewable energy and relieve climate change. However, it still key challenge achieve high selectivity CO simultaneously efficiency in photochemical reduction. Herein, we demonstrate the effect of Ni metal centers as catalytic active sites for photocatalytic by designing constructing metal-organic framework (Ni-MOF) materials. In pure CO2, Ni-MOF catalyst exhibits outstanding performance visible-light-driven...
The aim of the study was to examine effects environmental factors including disinfection on airborne microbiome during coronavirus disease 2019 pandemic, we evaluated indoor and outdoor air collected from 19 classrooms regularly disinfected. Extracted bacterial fungal DNA samples were sequenced using Illumina MiSeq™ platform. Using copy number concentrations qPCR analysis, multiple linear regressions as predictors performed. Microbial diversity community composition evaluated. Classrooms...
Francisella tularensis is the causative agent of tularemia and a category A bioterrorism agent. The molecular basis for extreme virulence remains unclear. Our recent study found that capBCA, three neighboring genes, are necessary infection F. live vaccine strain (LVS) in respiratory mouse model. We here show capBCA genes vivo growth LVS lungs, spleens, livers BALB/c mice. Unmarked deletion type Schu S4 resulted significant attenuation although level was much less profound than LVS. further...
Acute radiation-induced esophagitis (ARIE) is one of the most debilitating complications in patients who receive thoracic radiotherapy, especially those with esophageal cancer (EC). There little known about impact characteristics gut microbiota on initiation and severity ARIE.Gut samples EC undergoing radiotherapy (n = 7) or concurrent chemoradiotherapy 42) were collected at start, middle, end regimen. Assessment patient-reported ARIE was also performed. Based 16S rRNA gene sequencing,...
Our previous study reported that the metabolite of Bacillus subtilis BS-Z15 n-butanol site could reduce body weight gain in mice, showing anti-obesity effects. This further demonstrated effects purified mycosubtilin on and gut microbiota Kunming mice. 30 male white mice were randomly selected into three groups at four weeks age: Control (group A), gavage-administered with saline daily; treated B), metabolites (90 mg/kg); C), (6 mg/kg). Different groups’ compositions analyzed using...
Background Autism Spectrum Disorders (ASD) are defined as a group of pervasive neurodevelopmental disorders, and the heterogeneity in symptomology etiology ASD has long been recognized. Altered immune function gut microbiota have found populations. Immune dysfunction hypothesized to involve pathophysiology subtype ASD. Methods A cohort 105 children were recruited grouped based on IFN-γ levels derived from ex vivo stimulated γδT cells. Fecal samples collected analyzed with metagenomic...