A5087305482- Gut microbiota and health
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Folate and B Vitamins Research
- Ruminant Nutrition and Digestive Physiology
- Chronic Myeloid Leukemia Treatments
- Food Security and Health in Diverse Populations
- Diet and metabolism studies
- Reproductive System and Pregnancy
- Lymphoma Diagnosis and Treatment
- Genomics and Rare Diseases
- Reproductive Health and Contraception
- Genetic Associations and Epidemiology
- Pelvic floor disorders treatments
- Reproductive tract infections research
- Web Data Mining and Analysis
- Immunodeficiency and Autoimmune Disorders
- Advanced Text Analysis Techniques
- Sexual Differentiation and Disorders
- Hypothalamic control of reproductive hormones
- Rheumatoid Arthritis Research and Therapies
- Bioinformatics and Genomic Networks
- Plant Reproductive Biology
- Genomic variations and chromosomal abnormalities
Shenzhen Weiguang Biological Products (China)
2022
BGI Group (China)
2015-2021
China National GeneBank
2018-2020
Central South University
2014
Abstract Background The rumen microbiota provides essential services to its host and, through role in ruminant production, contributes human nutrition and food security. A thorough knowledge of the genetic potential microbes will provide opportunities for improving sustainability production systems. availability gene reference catalogs from gut microbiomes has advanced understanding health disease humans other mammals. In this work, we established a catalog prokaryote genes bovine rumen....
Abstract The gut microbiome has been established as a key environmental factor to health. Genetic influences on the have reported, yet, doubts remain significance of genetic associations. Here, we provide shotgun data for whole genome and metagenome from Chinese cohort, identifying no <20% contribution microbiota. Using common variants-, rare copy number variations-based association analyses, identified abundant signals associated with especially in metabolic, neurological, immunological...
More than a decade of gut microbiome studies have common goal improving human health. However, while most the disease focused on elderly or middle-aged, reference cohort for in young individuals has been lacking. It is also not clear what other omics data need to be measured better understand microbiome. Here, we present including 2183 adults with high-depth metagenomic shotgun sequencing fecal and data. In this multiomic cohort, observe number vitamins, hormones, amino acids, trace elements...
Helicobacter pylori infection (HPI) is a prevalent infectious disease associated with gastric ulcer, cancer, and many nongastrointestinal disorders. To identify genes that may serve as microbial markers for HPI, we performed shotgun metagenomic sequencing of fecal samples from 313 Chinese volunteers who had undergone C14 breath test. Through comparing differences in intestinal community structure between H. pylori-positive pylori-negative individuals, identified 58 HPI-associated species (P...
Pangenome analyses facilitate the interpretation of genetic diversity and evolutionary history a taxon. However, there is an urgent unmet need to develop new tools for advanced pangenome construction visualization, especially metagenomic data. Here, we present integrated pipeline, named MetaPGN, graphical visualization networks from either microbial genomes or metagenomes. Given isolated assemblies coupled with reference genome targeted taxon, MetaPGN generates in topological network,...
Background: Miscarriage is the most common adverse pregnancy outcome and more than 50% of its incidence remains unexplained. Earlier studies have suggested that maternal microbiota might be associated with miscarriage, but association insufficiently understood.
Abstract More than a decade of gut microbiome studies have common goal for human health. As most the disease sample elderly or middle-aged, reference cohort young individuals has been lacking. It is also not clear what other omics data need to be measured better understand microbiome. Here we present high-depth metagenomic shotgun sequencing fecal together with in 2,183 adults, and observe number vitamins, hormones, amino acids trace elements correlate cluster T cell receptors. Associations...
Summary The gut microbiome has been established as a key environmental factor to health. Genetic influences on the have reported, yet, doubts remain significance of genetic associations. Here, we provide shotgun data for whole genome and metagenome from Chinese cohort, identifying no less than 20% contribution microbiota. Using common variants-, rare variants- copy number variations (CNVs)-based association analyses, identified abundant signals associated with especially in metabolic,...
Abstract Background The rumen microbiota provides essential services to its host and, through role in ruminant production, contributes human nutrition and food security. A thorough knowledge of the genetic potential microbes will provide opportunities for improving sustainability production systems. availability gene reference catalogs from gut microbiomes has advanced understanding health disease humans other mammals. In this work, we established a catalog prokaryote genes bovine rumen....
Abstract Rationale: This study aimed to investigate the genetic mutation characteristics of congenital idiopathic hypogonadotropic hypogonadism (IHH) through clinical features and analysis 2 patients with IHH in 1 pedigree. Patient concerns: A 23-year-old girl presented primary amenorrhea, sparse pubic hair, lack breast development, delayed sexual development. Diagnoses: Combined characteristics, auxiliary examinations, molecular analysis, patient was diagnosed as IHH. Interventions: Whole...
Abstract A decade of studies has established the importance gut microbiome in human health. In spite sex differences physiology, lifespan, and prevalence many age-associated diseases, age disparities microbiota have been little studied. Here we show age-related adult microbial composition functionality two community-based cohorts from Northern China Netherlands. Consistently, women harbour a more diverse stable community across broad ranges, whereas men exhibit variable strongly correlated...
Genetic influences on the gut microbiome have been reported, yet, doubts remain as to significance of genetic associations. Here, we provide shotgun data for whole genome and metagenome from a Chinese cohort, identifying more than 20% contribution microbiota. Using common variants-, rare variants- copy number variations (CNVs)-based association analyses, identified abundant genome-microbiome especially in metabolic, neurological immunological functions. The enterotype may attribute, with top...
Abstract Chronic myelogenous leukaemia (CML) has a special phenomenon of chromosome translocation, which is called Philadelphia translocation. However, the detailed connection this structure troublesome and expensive to be identified. Low‐coverage whole genome sequencing (LCWGS) could not only detect previously unknown chromosomal but also provide breakpoint candidate small region (with an accuracy ±200 bases). Importantly, cost LCWGS about US$300. Then, with Sanger DNA sequencing, precise...
Numerous studies have established the importance of gut microbiota in human health. However, large-scale on impact sex and age are limited. Here we uncover unexpected age-related differences adult microbial composition functionality two large cohorts from China Netherlands. Compared to men, women harbor a more diverse surprisingly stable with no robust changes associated menopause. By contrast, men exhibit variable across broad ranges, exhibiting strong correlations age, testosterone levels,...
Abstract Background Abortion is a major problem affecting women's normal reproductive life. Non-whole chromosomes account for about 50% of abortions. In around cases, the etiology remains unknown. The present analysis was aimed to screen mutations at nucleotide level and detected new genetic origins human diseases. Results 72 abortion tissues (with abnormal chromosome reason excluded) were recruited whole-genome low coverage mate-pair sequencing (WGL-MPS) performed on each tissue. And used...
Abstract Background Interstitial deletions of chromosome band 10q11-q22 was a genomic disorder distinguished by developmental delay, congenital cleft palate and muscular hypotonia. The phenotypes involved were heterogeneous, hinge on the variable breakpoints size. Case presentation Here, we presented patient with soft cleft, growth development delay. 2 years 5 months girl who not able to walk unless using children’s crutches support herself. Whole-exome sequencing (WES) whole-genome...
Abstract Chronic Myelogenous Leukemia (CML) has a special phenomenon of chromosome translocation, which is called Philadelphia translocation. However, the detailed connection this structure troublesome and expensive to be identified. Low-coverage whole genome sequencing (LCWGS) could not only detect chromosomal translocation does known in advance, but also provide breakpoint candidate small region (with an accuracy ±200 bases). Importantly, cost LCWGS about US$300. Then, with Sanger DNA...