A5100401731- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- RNA Interference and Gene Delivery
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Parvovirus B19 Infection Studies
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Drug Transport and Resistance Mechanisms
- Chemokine receptors and signaling
- Porphyrin and Phthalocyanine Chemistry
- Metal complexes synthesis and properties
- DNA and Nucleic Acid Chemistry
- Nanoparticle-Based Drug Delivery
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
Northwestern University
2025
Guilin Medical University
2024
Chinese People's Liberation Army
2023
Peking University Shenzhen Hospital
2013-2022
University of Chinese Academy of Sciences
2022
Zhejiang Cancer Hospital
2022
Hunan Cancer Hospital
2022
Xiangya Hospital Central South University
2022
Central South University
2022
HiFiBiO Therapeutics (United States)
2022
Abstract While treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies T-cell have limited. Additionally, leukemias and lymphomas can commonly metastasize to CNS, where outcomes are poor options associated with severe side effects. Consequently, development safer more effective alternatives targeting malignant T cells that invaded CNS remains clinically important. CD5 previously shown effectively target various cancers in...
Lipid metabolism and the serine, one-carbon, glycine (SOG) methionine pathways are independently significantly correlated with estrogen receptor–negative breast cancer (ERneg BC). Here, we propose a link between lipid ERneg BC through phosphoglycerate dehydrogenase (PHGDH), rate-limiting enzyme in de novo serine pathway. We demonstrate that of paradigmatic medium-chain fatty acid octanoic leads to metabolic shift toward SOG pathways. PHGDH plays role both forward direction, contributing...
The emerging immune checkpoint blockade (ICB) therapy has ushered the cancer therapeutics field into an era of immunotherapy. Although ICB treatment provides remarkable clinical responses in a subset patients with cancer, this regimen fails to extend survival large proportion patients. Here, we found that combined estrogen receptor beta (ERβ) agonist and PD-1 antibody improved therapeutic efficacy mouse tumor models, compared monotherapies, by reducing infiltration myeloid-derived suppressor...
The immune status of tumors critically influences their responsiveness to PD1 blockades and other immune-based therapies. Programmed death ligand 1 (PD-L1) immunohistochemistry (IHC) is a clinically validated predictive biomarker response checkpoint-inhibitor therapy in limited number clinical settings but poorly most. With emerging evidence that multiple pathways immune-checkpoint proteins may coordinately contribute the adaptive resistance, identification quantitation markers tumor tissue...
Natural orifice specimen extraction surgeries (NOSES) have been applied to colorectal cancer (CRC). Different types of NOSES proposed. Traditional laparoscopic CRC (non-NOSES) widely adopted in clinical practice. Therefore, the safety and feasibility could be clarified by comparing with non-NOSES.Consecutive cases who underwent NOSE or non-NOSE rectal were retrospectively collected at Second Affiliated Hospital Harbin Medical University between 1 January 2013 31 December 2018. Other...
The aim of this study was to analyze the clinical features and laboratory findings adult Epstein-Barr virus associated T/NK cell lymphoproliferative disease (EBV+T/NK-LPD) investigate early diagnosis prognosis EBV+T/NK-LPD. data 19 patients with EBV+T/NK-LPD were retrospectively analyzed. results indicated that there 11 males 8 females. median age 32 years (range: 20-70 years). average duration from onset symptoms 3.5 months. survival time 2.5 Unkown fever, hepatosplenomegaly, liver...
Vaccination against SARS-CoV-2 has been the most important strategy for preventing infection and controlling pandemics of coronavirus disease 2019 (COVID-19). Cancer patients have a significantly higher risk with COVID-19 because their impaired immunity. Breast cancer is common female malignant tumor in world. However, studies on vaccination breast are scarce, so that more information needed to guide these.We conducted web-based questionnaire survey patient. Questionnaires completed by...
To explore the clinical characteristics, diagnosis, treatment outcome and prognosis of de novo CD5 positive diffuse large B cell lymphoma (CD5(+)DLBCL), data 10 patients with pathologically confirmed CD5(+)DLBCL were retrospectively analyzed. The results indicated that 9 out older than 60 years. All cases in III/IV stages according to Ann-Arbor Staging System. Bone marrow biopsy immunohistochemistry showed involvement 5 cases. Nine received chemotherapy anti-CD20 monoclonal antibody...
Abstract Chronic myelogenous leukaemia (CML) has a special phenomenon of chromosome translocation, which is called Philadelphia translocation. However, the detailed connection this structure troublesome and expensive to be identified. Low‐coverage whole genome sequencing (LCWGS) could not only detect previously unknown chromosomal but also provide breakpoint candidate small region (with an accuracy ±200 bases). Importantly, cost LCWGS about US$300. Then, with Sanger DNA sequencing, precise...
Cancer is one of the diseases that seriously threaten health peoples. As a representative metal drugs, cisplatin has considerable promise for treatment cancer. However, side effects are major problems due to their poor selectivity cancer cells. We report here, first time, syntheses three new water‐soluble porphyrin‐modified copper(II) complexes Cu‐P1 , Cu‐P2 and Cu‐P3 . Results from calf thymus DNA (ct‐DNA)‐binding efficiency tests show could obviously interact with ct‐DNA characterized...
<div>Abstract<p>Fusion genes including NPM–ALK can promote T-cell transformation, but the signals required to drive a healthy T cell become malignant remain undefined. In this study, we introduce into primary human cells and demonstrate induction of epithelial-to-mesenchymal transition (EMT) program, attenuation most effector programs, reemergence an immature epigenomic profile, dynamic regulation c-Myc, E2F, PI3K/mTOR signaling pathways early during transformation. A mutant...
Supplementary Figures Legends 1-3 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Cell Growth through Inducing Apoptosis
Supplementary Figure 1 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Cell Growth through Inducing Apoptosis
Supplementary Figure 3 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Cell Growth through Inducing Apoptosis
Supplementary Figure 2 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Cell Growth through Inducing Apoptosis
Supplementary Figure 2 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Cell Growth through Inducing Apoptosis
Supplementary Figure 3 from <i>CMTM3</i>, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Cell Growth through Inducing Apoptosis
<div>Abstract<p>Fusion genes including NPM–ALK can promote T-cell transformation, but the signals required to drive a healthy T cell become malignant remain undefined. In this study, we introduce into primary human cells and demonstrate induction of epithelial-to-mesenchymal transition (EMT) program, attenuation most effector programs, reemergence an immature epigenomic profile, dynamic regulation c-Myc, E2F, PI3K/mTOR signaling pathways early during transformation. A mutant...
To investigate the clinical and laboratory features of patient with B cell lymphoma associated hemophagocytic syndrome(B-LAHS).The data 10 cases B-LAHS were retrospectively analysed relevant literatures reviewed.The median age diagnosed as was 55.5 (31-88) years old, time from attack to diagnosis 2 months (2 weeks-4 months). The can be made histopathologically immunohistochemically by bone marrow biopsy. Among them 7 large lymphoma, mantle 1 case small lymphoma. prominent symptoms signs...