A5084045544- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders Research
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Parvovirus B19 Infection Studies
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
Peking University Shenzhen Hospital
2009-2023
Abstract While treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies T-cell have limited. Additionally, leukemias and lymphomas can commonly metastasize to CNS, where outcomes are poor options associated with severe side effects. Consequently, development safer more effective alternatives targeting malignant T cells that invaded CNS remains clinically important. CD5 previously shown effectively target various cancers in...
T-cell lymphomas are aggressive that often resist current therapy options or present with relapsed disease, making the development of more effective treatment regimens clinically important. Previously, we have shown CD4 CAR can effectively target malignancies in preclinical studies. As IL-15 has been to strengthen anti-tumor response, modified secrete an IL-15/IL-15sushi complex. These CD4-IL15/IL15sushi T cells and NK92 efficiently eliminated CD4+ leukemic cell lines co-culture assays....
Abstract Antiphospholipid syndrome (APS) is a rare autoimmune systemic disorder. Previously, no report suggests that APS could progress to extranodal marginal zone lymphomas (EMZL). In this study, we met an unusual patient with such progression EMZL. The patients had been diagnosed two years ago and was in stable condition after regular treatment until his readmission our hospital re‐diagnosed EMZL recently. Coincidentally, noticed the immunized against inactivated COVID‐19 vaccine just 2...
Objective To investigate the cytogenetic and immunological phenotypes of acute myeloid leukemia (AML) with t(8;21),and explore risk stratification risk-adapted treatments.Methods The chromosomal karyotype bone marrow was detected analyzed in 22 newly diagnosed patients t(8;21) AML by direct culture G banding technique.Patients were divided into two groups according to karyotypes.Clinical characteristics compared between isolated those additional aberrations.A follow-up study median time 30...
Objective To analyze and study the diagnosis of large granular lymphocyte leukemia(LGLL).Methods report discuss six cases weth LGLL we have found. Results 2 T-LGLL lof NK-LGLL had indolent process, mainly presenting with anemia splenomegaly good response to treatment, while; 1 aggressive their clinical characters are obviously general symptom, hepatomegaly,splenomegaly,these disease develop quickly bad prognosis. The immunophenotype is distinct from cases. Conclusion As a group heterogeneous...
Objective To explore the features of patients with acute leukemia (AL) in Hematology Department Shenzhen Hospital affliated to Beijing University during past six years. Methods The data 1056 dignosed our department between 2002-2007 were collected and analyzed retrospectively. Results male was predominant (male/female ratio 1.78). number myeloid leukemia(AML) higher than that lymphoblastic (ALL) (AML/ALL 1.85). Most AML young adult (65 %) elderly ALL very rare(1.33 %). AL cases tended...
Objective To explore the clinical significance of fms-like tyrosine kinase3(FLT3) expression in evaluation prognosis acute myeloid leukemia(AML) prognosis.Methods 50 patients with AML were selected.AML normal karyotype 20 cases,the abnormal 30 cases.3ml bone marrow before themotherapy was aspirated respectively,and FLT3 gene leukemia cells detected polyenzyme chain react(PCR).Results The rate 5.0％,and 26.7％ karyotype,33.3％ refractory-relapse,and 4.5％ continue remission.The related high...
Objective To study the relationship of immunophenotype and prognosis acute leukemia(AL). Methods 75 patients with AL were analyzed expression by FCM evaluated effect differ-ent to prognosis. Results (1) The incidence CD13, CD33, CD64, CD117 in AML was 82%. CD2, CD3, CD7, CD19, CD20 ALL 88%. lymphocytic lineage antigen AML(Ly + AML) 13% myeloid ALL(My ALL) 11%. (2)According expression, could be classified into three subgroups:lineage-specific expres-sion;mixture-lineage null type....
Objective To investigate the clinical and laboratory diagnosis of adult hemophagocytic syn-drome (HPS) . Methods Clinical data 24 patients with HPS from 2000 to 2008 were retrospectively analyzed. Results Of cases, 12 had a malignant associated syndrome (MHAS), 10 fi-nally diagnosed by bone marrow immunohistochemist ;Of cases in non-MAHS group,4 virus (VAHS), 4 other infections, whereas immune HS (MAS). There significant difference onset age, mortality, serum lactate dehydrogenase (LDH)...
To explore the lymphocytic clonal expansion in adult patients with Epstein-Barr virus-associated lymphoproliferative diseases (EBV+LPD), and to investigate experimental methods for EBV+LPD cells so as provide a more objective measure diagnosis, classification prognosis early stage of this disease.Peripheral blood samples from 5 EBV+LPD, 4 infectious mononucleosis(IM) negative control 3 acute NK-cell leukemia(ANKL) positive were collected. Prior immunochemotherapy, viral loads clonality...
Objective: To evaluate the reliability of flow cytometry (FCM) for diagnosing lymphoma associated hemophagocytic syndrome (LAHS). Method: The clinical data in 57 patients with lymphohistiocytosis (HLH)were retrospective analyzed at Peking University Shenzhen Hospital from July 2010 to 2019. All were performed bone marrow FCM and pathological examination before final diagnoses made. golden diagnosis criterion was based on clinical, biochemical histopathological evidence, which regarded as...