Clinical and laboratory diagnosis of adult hemophagocytic syndrome

• DOI: 10.3760/cma.j.issn.1008-6315.2009.05.023
• Publication Date: 2009-05-01
• Authors: Hongyu Zhang; Qing-xiang Meng; Jin Liu; Liping Pang; Jun Wang; Lei Xu; Jia Feng; Wenli Zhang; Qian Zhagn; Lihua Sun; Feng-luan Zhong; Hai-chan Xu; Jiren Yu
• Keywords: Etiology; Hemophagocytosis

Objective To investigate the clinical and laboratory diagnosis of adult hemophagocytic syn-drome (HPS) . Methods Clinical data 24 patients with HPS from 2000 to 2008 were retrospectively analyzed. Results Of cases, 12 had a malignant associated syndrome (MHAS), 10 fi-nally diagnosed by bone marrow immunohistochemist ;Of cases in non-MAHS group,4 virus (VAHS), 4 other infections, whereas immune HS (MAS). There significant difference onset age, mortality, serum lactate dehydrogenase (LDH) ferritin(FER) neutrophilic NAP between group MAHS group(P <0.01 ,P<0.05). In all biopsy showed differences cytological pathological features group. Conclusion Etiology,immunology,and cell pathology as well contribute typing will give guide therapy.

Key words: Adult syndrome; diagnosis; Laboratory