Risk stratification and analysis of prognostic factors of acute myeloid leukemia with t(8;21)

• DOI: 10.3760/cma.j.issn.1009-9921.2013.07.014
• Publication Date: 2013-07-25
• Authors: Jia Feng; Jin Liu; Hai-chan Xu; Wenli Zhang; Qian Zhang; Feng-luan Zhong; Qing-xiang Meng

Objective To investigate the cytogenetic and immunological phenotypes of acute myeloid leukemia (AML) with t(8;21),and explore risk stratification risk-adapted treatments.Methods The chromosomal karyotype bone marrow was detected analyzed in 22 newly diagnosed patients t(8;21) AML by direct culture G banding technique.Patients were divided into two groups according to karyotypes.Clinical characteristics compared between isolated those additional aberrations.A follow-up study median time 30 months (4-68 months) conducted analyze prognostic factors.Results 13 cases (59.1％) AML,while 9 (40.9 ％) had aberrations.Loss sex chromosome found 3 complex variant translocation 2.The 10q-,9q-,-18 +10 single cases.Overall survival aberrations significantly poorer than t (8;21) (P =0.0176).Analysis factors showed that karyotype,initial white blood cells at diagnosis,and treatment regimen (chemotherapy alone or plus hematopoietic stem cell transplantation) effects on overall survival.Conclusion Patients are frequently associated aberrations.The latter indicates a outcome can be one bases stratification.Hematopoietic transplantation might help improve survival.

Key words: Leukemia, myeloid, acute; t(8; 21); Prognosis; Karyotyping