A5101854509- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Trauma and Emergency Care Studies
- Acute Ischemic Stroke Management
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Coronary Interventions and Diagnostics
- Immune cells in cancer
- Signaling Pathways in Disease
- Biomarkers in Disease Mechanisms
- Galectins and Cancer Biology
- S100 Proteins and Annexins
- Cholesterol and Lipid Metabolism
- Noise Effects and Management
- PARP inhibition in cancer therapy
- Abdominal vascular conditions and treatments
- Cardiac Fibrosis and Remodeling
- Erythropoietin and Anemia Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- HIV, Drug Use, Sexual Risk
- Neuroinflammation and Neurodegeneration Mechanisms
Tongji Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Southern Medical University
2009-2025
Zhejiang Chinese Medical University
2024
Zhujiang Hospital
2009-2022
Tongji University
2022
State Key Laboratory of Biotherapy
2020
Sichuan University
2020
Shantou University
2019
First Affiliated Hospital of Shantou University Medical College
2019
Ticagrelor improves the clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). However, few studies have directly compared efficacy and safety of ticagrelor against clopidogrel, an oral, thienopyridine-class antiplatelet drug. This study clopidogrel STEMI PPCI.We enrolled 400 PPCI at Zhujiang Hospital Southern Medical University First Qinhuangdao, China, between January 01, 2013 April 30, 2015. All received...
Lymphocyte decline, particularly the depletion of NK cells, is a prominent feature immunosuppression following severe tissue injury, heightening susceptibility trauma patients to life-threatening infections. Previous research indicates that reduction in number cells closely associated with process cell death. Nonetheless, precise mechanism death remains unknown. Here, we discovered traumatic undergo several pathways, dominated by apoptosis and pyroptosis coexistence necrotic death,...
The emerging immune checkpoint blockade (ICB) therapy has ushered the cancer therapeutics field into an era of immunotherapy. Although ICB treatment provides remarkable clinical responses in a subset patients with cancer, this regimen fails to extend survival large proportion patients. Here, we found that combined estrogen receptor beta (ERβ) agonist and PD-1 antibody improved therapeutic efficacy mouse tumor models, compared monotherapies, by reducing infiltration myeloid-derived suppressor...
Aging is an important factor affecting the deterioration of patients with coronavirus disease 2019 (COVID-19). The aging and degeneration various tissues organs in elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular diabetes aged are associated higher mortality. Severe acute respiratory syndrome 2 (SARS-CoV-2) primarily interacts cell surface receptor angiotensin-converting enzyme (ACE) other accessory proteins 78 kDa glucose-regulated...
Abstract The sinoatrial node (SAN) is the origin of electrical signals for rhythmic heartbeats in mammals. spontaneous firing SAN pacemaker cells (SANPCs) triggers cardiac contraction. ‘Local Ca 2+ release’ (LCR), a unique cellular activity, acts as ‘engine’ SANPCs. However, mechanism LCR initiation remains unclear. Here, we report that endogenous glutamate drives LCRs Using sensor, unraveled tight correlation between accumulation and occurrence, indicating potential relationship LCRs....
As an acute respiratory infectious disease, COVID-19 threatens the safety of global public health. Given current lack specific treatment against this research and development vaccines have become sharp weapons for overcoming pandemic. mRNA lead in vaccination strategies due to their advantages, such as rapid industrial production efficacy. A total 137 entered clinical trial stage, among which 23 are vaccines, accounting 17% vaccines. Herein, we summarize developmental processes well approach...
Helix B surface peptide (HBSP), a newly developed tissue-protective erythropoietin derivative, has beneficial effects on myocardial ischemia. This study aimed to investigate the cardio-protective of HBSP against hypoxia/reoxygenation (H/R) injury and its possible mechanism.A rat-derived cardiomyocyte cell line (H9C2 cells) were established pretreated with HBSP. The primary cultures subjected H/R monitored for viability using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide...
Background Trauma-induced immune dysfunction has been a major barrier to achieving reduced mortality, which is poorly understood. Autophagy crucial catabolic mechanism of cells during times stress. Few studies have investigated the regulatory effects induced by autophagy after trauma. Here, we use single-cell transcriptomics analysis in trauma cohort demonstrate dominant role innate early stages Method Single-cell transcriptional profiling peripheral blood mononuclear (PBMCs) was performed,...
To investigate the influence of statins on major adverse cardiovascular events (MACE) in patients with coronary microvascular dysfunction (CMVD).23,494 who received angiography (CAG) were included. Thrombolysis Myocardial Infarction, Perfusion Grading (TMPG), a useful angiographic method, was used to evaluate CMVD.Using multivariate analysis, NYHA III/IV (HR, 1.44; 95% CI, 1.03-2.01; P=0.031), PCI history 3.69; 2.57-5.31; P<0.001), TG 1.15; 1.06-1.26; P=0.001), creatinine 1.00; 1.00-1.01;...
Abstract: Glioblastoma is the most common form of malignant brain tumors and has a poor prognosis. Glioma stem cells (GSCs) are thought to be responsible for aberrant proliferation invasion. Targeting signaling pathways that promote in GSCs one strategies glioma treatment. In this study, we found increased expression contactin 2 (CNTN2) amyloid β precursor protein (APP) U87-derived (U87-GSCs). RNA interference (RNAi) CNTN2 downregulated APP intracellular domain (AICD), which proteolytic...
The research objective was to evaluate the predicting role of vascular endothelial growth factor CBP/P300-interacting transactivator with Glu/Asp-rich C-terminal domain 2 Ratio (VEGF/CITED2) from peripheral blood mononuclear cells (PBMCs) in collateral circulation acute ischemic stroke (AIS).In an observational study patients AIS, western blot applied test protein expression VEGF and CITED2. Then, we calculated VEGF/CITED2 collected other clinical data. Binary logistic regression analysis...
Objective Polytrauma is a complex condition associated with poor outcomes and high mortality rates resulting from severe damage complicated complications. This study sought to ascertain the incidence of chronic complications in polytrauma patients, as well early immune changes risk factors. Methods A multicenter, prospective observational cohort was conducted at emergency surgery or traumatic intensive care unit (TICU) Advanced Trauma Center August 2020 July 2023. total 2033 consecutive...
Previous reports have indicated the occurrence of acute gastrointestinal injury (AGI) in critically ill individuals. Yet, there is limited information regarding frequency and potential causes AGI individuals with polytrauma. The complicated diagnostic tools often mistaken mislead evaluation AGI. objective this research to create a nomogram that can predict likelihood Among 836 polytrauma patients, occurred 61.2%, significantly higher than 9.5% monotrauma patients (P < 0.001).The predictors...
Pancreaticoduodenal artery (PDA) aneurysms are extremely rare. The complicated clinical presentations and high incidence of rupture make it difficult to diagnose treat. PDA pseudoaneurysms often into the gastrointestinal tract result in life-threatening hemorrhage.A 69-year-old man was admitted our hospital due right upward abdominal pain. A computed tomography (CT) scan demonstrated acute cholecystitis cholecystolithiasis. Percutaneous gallbladder drainage performed subsequently. He...