A5103277403- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticle-Based Drug Delivery
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Advanced X-ray and CT Imaging
- COVID-19 diagnosis using AI
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Maternal and fetal healthcare
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Atomic and Subatomic Physics Research
- Luminescence and Fluorescent Materials
- MRI in cancer diagnosis
- Ectopic Pregnancy Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Colorectal and Anal Carcinomas
- Biliary and Gastrointestinal Fistulas
- Calcium signaling and nucleotide metabolism
- Extracellular vesicles in disease
Shanghai Jiao Tong University
2018-2025
XinHua Hospital
2018-2025
Indiana University School of Medicine
2018
Ruijin Hospital
2012
Inner Mongolia Electric Power (China)
2010
BackgroundThe ongoing outbreak of COVID-19 pneumonia is globally concerning. We aimed to investigate the clinical and CT features in pregnant women children with this disease, which have not been well reported.MethodsClinical data 59 patients from January 27 February 14, 2020 were retrospectively reviewed, including 14 laboratory-confirmed non-pregnant adults, 16 25 clinically-diagnosed women, 4 children. The analyzed compared.FindingsCompared adults group (n = 14), initial normal body...
Various squaraine dyes have been developed for biological imaging. Nevertheless, with emission in the second window (NIR-II, 1000–1700 nm) few reports largely due to short of a simple and universal design strategy. In this contribution, molecular engineering strategy is explored develop NIR-II emission. First, NIR-I dye SQ2 constructed by ethyl-grafted 1,8-naphtholactam as donor units square acid acceptor unit donor–acceptor–donor (D–A–D) structure. To red-shift fluorescence into window,...
Because of the lack specific targets, highly aggressive triple negative breast cancer (TNBC) is unable to benefit from endocrine therapy or conventional targeting therapy. Even worse, current diagnostic and therapeutic approaches have limited value for TNBC. Therefore, developing TNBC-specific theranostic probes accurate diagnosis further selective will build a powerful toolbox TNBC management. In this contribution, we developed sequential strategy enhance specificity theranostics. system,...
A peptide-modified gold nanoparticle was developed for tumour-targeted therapy. Triggered by alkaline phosphatase, the CREKA-YPFFK(Nph) peptide can self-assemble and further result in accumulation of nanoparticles tumour cells. The large-sized aggregates cannot escape from tissue, therefore realizing goal tumour-specific targeting, enhanced retention photothermal effects.
We developed a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy.
Semiconducting polymer (SP)-based afterglow luminogens are showing increasing potential for in vivo imaging because of their long-life luminescence and the associated benefits (e.g., zero-autofluorescence background high signal-to-noise ratio). However, such organic agents still rare application is usually limited by relatively low intensity short duration. Herein, we report an aggregation-induced emission (AIE) dye-powered SP luminogen leveraging on unique characteristics AIE dye to...
Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value chest CT radiomics diagnosing pneumonia compared with clinical model reporting system (CO-RADS), develop an open-source diagnostic tool constructed model.This enrolled 115 laboratory-confirmed 435 non-COVID-19 patients (training dataset, n = 379; validation 131; testing 40). Key features extracted from images were selected build a signature...
Background: The ongoing outbreak of COVID-19 pneumonia is globally concerning. We aimed to investigate the clinical and CT features in pregnant women children with this disease, which have not been well reported. Methods: Clinical data 59 patients from January 27 February 14, 2020 were retrospectively reviewed, including 14 laboratory-confirmed non-pregnant adults, 16 25 clinically-diagnosed women, 4 children. analyzed compared. Findings: Compared adults group (n=14), initial normal...
The combination of programmed cell death ligand-1 (PD-L1) immune checkpoint blockade (ICB) and immunogenic (ICD)-inducing chemotherapy has shown promise in cancer immunotherapy. However, triple-negative breast (TNBC) patients undergoing this treatment often face obstacles such as systemic toxicity low response rates, primarily attributed to the immunosuppressive tumor microenvironment (TME). In study, PD-L1-targeted theranostic systems were developed utilizing anti-PD-L1 peptide (APP)...
Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 was delivered PADN in thromboxane A2 (TxA2) - induced acute PH swine model. demonstrated that by 20-Gy SBRT reduced mean (PA) pressure during the TxA2 challenge. All dosages led deeper area compared with radiofrequency ablation (RFA) and...
Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such combination therapeutic regimen encountered challenges, as limited photosensitizer bioavailability and severe drug toxicity. Herein, ultrasmall metal-organic frameworks (MOFs) nanodots (MSPC) that encapsulate inhibitors mitochondria-targeted photosensitizers are designed fabricated for (PDT) TNBC. The MSPC exhibits an...
Abstract The conventional blue Te nanostructures exhibit strong photoabsorption in the near‐infrared (NIR) region but have ultralong lengths (tenths of micrometers), while purple with short (such as nanodots and nanorods) show extremely low intensity NIR band. These cannot achieve simultaneously both suitable size high absorption, undoubtedly hindering their bioapplication. Herein, nanoneedles are prepared through a facile one‐pot reduction route for first time, they absorbance maintaining...
Importance Ambroxol was identified as an enhancer of stability and residual activity several misfolded glucocerebrosidase variants in 2009. Objectives To assess hematologic visceral outcomes, biomarker changes, safety ambroxol therapy for patients with Gaucher disease (GD) without disease-specific treatment. Design, Setting, Participants Patients GD who could not afford enzyme replacement were enrolled received oral from May 6, 2015, to November 9, 2022, at Xinhua Hospital, affiliated...
To investigate the clinico-radiological findings and outcomes in pregnant women with COVID-19 pneumonia compared to age-matched non-pregnant women.A retrospective case-controlled study was conducted review clinical CT data of 21 19 pneumonia. Four stages images were analyzed based on time interval from symptom onset: stage 1 (0-6 days), 2 (7-9 3 (10-16 4 (>16 days). The initial follow-up compared.Compared women, absence fever (13/21, 62%) normal lymphocyte count (11/21, 52%) more frequent...
The prevalence and fatality rates of gastric cancer (GC) remain elevated, with advanced stages presenting a grim prognosis. Noninvasive diagnosis GC often proves challenging until the disease has progressed to an stage or metastasized. Initially, level fibronectin (FN) in cancer-associated fibroblasts (CAFs) was at least 3.7 times higher than that normal fibroblasts. Herein, two FN-targeting magnetic resonance/near-infrared fluorescence (MR/NIRF) imaging contrast agents were developed detect...
Abstract Background Triple negative breast cancer (TNBC) occurs in approximately 10% to 25% of all patients with and is associated poor prognosis. Neo-adjuvant chemotherapy has been reported produce a higher pathologic complete response (pCR) rate TNBC. If pCR achieved, TNBC had similar survival non-TNBC patients. The aim our study was investigate the protein expression epithelial growth factor receptor (EGFR) neo-adjuvant clinical outcome compared non-TNBC. Methods A total 198 locally...
Abstract Background Various features extracted from breast MRI have the potential to serve as noninvasive biomarkers for prediction of biologic behavior cancer. The purpose this study was investigate value focal edema and score (BES) on T2-weighted images in providing valuable biological information cancer patients’ personalized treatment. Method Two hundred five lesions 201 patients with invasive confirmed by surgery or biopsy Xinhua Hospital Affiliated Shanghai Jiaotong University School...
Background Recent studies showed the potential of MRI‐based deep learning (DL) for assessing treatment response in rectal cancer, but role DL evaluating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation remains unclear. Purpose To develop a method based on T2‐weighted imaging (T2WI) and clinical factors noninvasively KRAS cancer. Study Type Retrospective. Subjects A total 376 patients (108 women [28.7%]) with histopathology‐confirmed adenocarcinoma status. Field Strength/Sequence...
To develop a novel fluorine-18 (18F)-labeled arginine-glycine-aspartic acid (RGD)-coupled ultra-small iron oxide nanoparticle (USPIO) (hereafter, referred to as 18F-RGD@USPIO) and conduct an in-depth investigation monitor the anti-angiogenic therapeutic effects by using dual-modality PET/MRI probe.The RGD peptide 18F were coupled onto USPIO click chemistry. In vitro experiments including determination of stability, cytotoxicity, cell binding obtained 18F-RGD@USPIO carried out, targeting...
Background: Limited data were available for profiling the COVID-19 in pregnant women and their neonates. This study aimed to investigate clinico-radiological findings outcomes with compared age-matched non-pregnant women, assess status of neonates.Methods: Clinical CT 21 19 from January 23 March 4, 2020 retrospectively reviewed. Four stages images both groups analyzed based on time intervals symptom onset: stage 1 (0-6 days, n=40), 2 (7-9 n=27), 3 (10-16 n=22), 4 (>16, n=28). The clinical...
Prognostic evaluation is important for personalized treatment in children with medulloblastoma (MB). Limited data are available risk stratification using a radiomics-based model.To evaluate the incremental value of an MRI radiomics signature stratifying pediatric MB terms overall survival (OS).Retrospective.A total 111 (mean age 5.82 years) pathologically confirmed divided into training and validation cohorts (77 34 children, respectively).A 3 T, contrast-enhanced T1-weighted imaging...