A5101999491- Oral microbiology and periodontitis research
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Renin-Angiotensin System Studies
- Palliative Care and End-of-Life Issues
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Alzheimer's disease research and treatments
- Medical Research and Treatments
- Neurological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Mycobacterium research and diagnosis
- Thermal Regulation in Medicine
- Stress Responses and Cortisol
- Neonatal Respiratory Health Research
- Spondyloarthritis Studies and Treatments
- Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
XinHua Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Capital Medical University
2016-2024
First Hospital of China Medical University
2024
Central Hospital of Putuo District
2024
Chinese PLA General Hospital
2024
Shandong First Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Shandong Tumor Hospital
2024
Fuling Center Hospital of Chongqing
2019
The combination of programmed cell death ligand-1 (PD-L1) immune checkpoint blockade (ICB) and immunogenic (ICD)-inducing chemotherapy has shown promise in cancer immunotherapy. However, triple-negative breast (TNBC) patients undergoing this treatment often face obstacles such as systemic toxicity low response rates, primarily attributed to the immunosuppressive tumor microenvironment (TME). In study, PD-L1-targeted theranostic systems were developed utilizing anti-PD-L1 peptide (APP)...
Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such combination therapeutic regimen encountered challenges, as limited photosensitizer bioavailability and severe drug toxicity. Herein, ultrasmall metal-organic frameworks (MOFs) nanodots (MSPC) that encapsulate inhibitors mitochondria-targeted photosensitizers are designed fabricated for (PDT) TNBC. The MSPC exhibits an...
Objective: Type 2 diabetes mellitus (T2DM) is related to an elevated risk of mild cognitive impairment (MCI). Plasma clusterin reported associated with the early pathology Alzheimer's disease (AD) and longitudinal brain atrophy in subjects MCI. The rs11136000 single nucleotide polymorphism within (CLU) gene also AD. We aimed investigate associations among plasma clusterin, genotype T2DM-associated Methods: A total 231 T2DM patients, including 126 MCI 105 cognitively healthy controls were...
BACKGROUND: Bicyclol was used for treating idiosyncratic acute drug-induced liver injury (DILI) in a phase II trial. This study aimed at evaluating the efficacy and safety of bicyclol 25 50 mg thrice day (TID) DILI caused by anti-TB drugs light trial results. METHODS: We analysed clinical data patients with TB database. The primary endpoint reduction serum alanine aminotransferase (ALT) levels after 4 weeks treatment compared to baseline. RESULTS: Overall, 148 were included, respectively 48,...
Abstract Background The usefulness of postoperative adjuvant chemotherapy (ACT) for patients with stage I lung adenocarcinoma micropapillary (MIP) components remains unclear. We analyzed whether ACT could reduce recurrence in MIP components, thereby improving their overall survival (OS) and disease‐free (DFS). Methods Data pathologically confirmed from January 2012 to December 2018 were retrospectively analyzed. OS DFS groups subgroups. Results Overall, 259 enrolled. Patients who received IA...
Abstract Periodontitis is a significant independent risk factor for atherosclerosis. Yet, the exact mechanism of action still not fully understood. In this study, we investigated effect exosomes‐miR‐155‐5p derived from periodontal endothelial cells on atherosclerosis in vitro and vivo. Higher expression miR‐155‐5p was detected plasma exosomes patients with chronic periodontitis (CP) carotid (CAS) compared to CP. Also, level associated severity miR‐155‐5p‐enriched HUVECs increased...
Abstract Type 2 diabetes mellitus (T2DM) is a low-grade chronic inflammatory diseases, which have been implicated in the pathogenesis of cognitive decline. We aim to evaluate associations between markers and risk mild impairment (MCI) T2DM. This study 140 diabetic patients involved 71 with MCI 69 controls. Clinical parameters, neuropsychological tests, high sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6), lipoprotein-associated Phospholipase A2 (Lp-PLA2) mass activity were...
To investigate the role of glutamatergic neurons in dorsomedial periaqueductal grey (dmPAG) regulating excessive defensive behaviors mice with post-traumatic stress disorder (PTSD).
As the most common gastrointestinal malignancy worldwide, liver metastases occur in half colorectal cancer (CRC) patients. Early detection can help treat them early and reduce mortality patients with (CRLM). Finding useful biomarkers for CRLM is thus essential. The TCGA GEO databases were used to download expression profiles clinical data of Differential analysis screened genes associated CRLM, univariate Cox regression identified prognosis. least absolute shrinkage selection operator...
Objective: To investigate the effects and mechanisms of microRNA-146a (miR-146a) on osteogenic differentiation human periodontal ligament cells (hPDLC) stimulated by lipopolysaccharide (LPS) Porphyromonas gingivalis (Pg). Methods: hPDLC were cultured in vitro induced to phase differentiation. These divided into five groups: non-osteogenic cells, treated with Pg LPS, LPS miR-146a mimic, negative control. Osteogenic markers mineralization detected via quantitative real-time PCR (qPCR) alizarin...
Background: Angiotensin-converting enzyme (ACE) is involved in the chronic complications of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. This study aimed to assess pathogenetic roles ACE genetic predisposition its insertion/deletion (I/D) polymorphism mild cognitive impairment (MCI) among T2DM patients. Methods: A total 210 patients were enrolled. Among these patients, 116 satisfied MCI diagnostic criteria 94 exhibited healthy cognition. The functions extensively assessed. serum...
Background: Colorectal cancer (CRC) is one of the most common malignant tumors and has high morbidity mortality rates.Previous studies have shown that TSPEAR mutations are involved in development progression gastric liver cancer.However, role CRC still unclear.Methods: In The Cancer Genome Atlas (TCGA) database, 590 patients with complete survival information were analyzed.We assessed expression a pan-cancer dataset from TCGA database.Cox regression analysis was performed to evaluate factors...
ABSTRACT Aim To investigate the role of lipopolysaccharide (LPS) from Porphyromonas gingivalis and miR‐155‐5p‐enriched exosomes in formation foam cells occurrence carotid atherosclerosis (CAS). Methods The CAS tissue samples plasma healthy control group or patients undergoing periodontitis without with were collected at Xuanwu Hospital, Capital Medical University. expression level miR‐155‐5p was evaluated by immunofluorescent analysis qRT‐PCR. Oil red O staining lipid accumulation assays...
<title>Abstract</title> <bold>Background: </bold>With the progress of graduate education in China, development society, and deepening medical reforms, professional has become an important trend cultivating high-level nursing talents. An increasing number male students are joining workforce. Investigating experiences during their learning process, analyzing relevant factors affecting education, exploring potential solutions can provide references for educators administrators. This contributes...