A5065821162- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Infectious Diseases and Tuberculosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Neurological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Photodynamic Therapy Research Studies
- Multiple Sclerosis Research Studies
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Nuclear Receptors and Signaling
- Retinal Diseases and Treatments
- Stroke Rehabilitation and Recovery
- Flavonoids in Medical Research
- Bacterial Infections and Vaccines
- Mesenchymal stem cell research
- Cell death mechanisms and regulation
- RNA regulation and disease
- Tuberculosis Research and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
Jiangxi Provincial People's Hospital
2008-2025
First Affiliated Hospital of Jiangxi Medical College
2022-2025
Nanchang University
2019-2023
Jiangxi Provincial Children's Hospital
2023
Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin biguanide drug that exerts strong effects on multiple diseases. This study aims to evaluate the protective effect of metformin against retinal I/R its underlying mechanism. induced reduction retina thickness cell number ganglion layer, alleviated I/R-induced injury. Both simulated (SIR) R28 cells down-regulated...
Abstract Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells plays an important role occurrence development human tumors. However, function mechanism heterogeneous nuclear ribonucleoprotein C (HNRNPC), RNA-binding protein m6A reader gliomas remains to be comprehensively extensively explored. Herein, we found that HNRNPC mRNA overexpression were associated with a poor prognosis for patients...
Abstract Objective Although blood urea nitrogen (BUN) has a crucial impact on many diseases, its effect outcomes in patients with hyperlipidemia remains unknown. The study aimed to investigate the relationships between BUN levels and all-cause cardiovascular disease (CVD) mortality individuals hyperlipidemia. Methods This analysis comprised 28,122 subjects from National Health Nutrition Examination Survey (NHANES) spanning 1999 2018. risk of was evaluated using weighted Cox regression...
Cisplatin (DDP) is the first-line chemotherapeutic agent for ovarian cancer. However, development of DDP resistance seriously influences effect and prognosis It was reported that can directly impinge on mitochondria activate intrinsic apoptotic pathway. Herein, role mitochondrial dynamics in chemoresistance human cancer SKOV3 cells investigated. In DDP-resistant SKOV3/DDP cells, fission protein DRP1 down-regulated, while fusion MFN2 up-regulated. accordance with expression MFN2, average...
Baló's concentric sclerosis (BCS) is a rare demyelinating disorder usually considered variant of multiple (MS). However, its pathogenesis and correlation with MS remains unclear controversial. This report presents seven Hans Chinese subjects diagnosed as BCS on the basis pathognomonic MR (magnetic resonance) findings. Upon diagnosis, all cases displayed good responses to corticosteroids showed an overall benign prognosis during follow-up period 4-13.5 years, although three relapsed later....
Age-related macular degeneration is a common cause of blindless among the aged, which can mainly be attributed to oxidative stress and dysregulated autophagy in retinal pigment epithelium cells. Lactate was reported act as signaling molecule exerted beneficial effect against stress. This study aims investigate protective lactate stress-induced degeneration. Here, H2O2-induced cell model sodium iodate-induced mice were established. It found that H2O2 inhibited viability ARPE-19 cells iodate...
Corneal alkali burn, one of the most serious ophthalmic emergencies, is difficult to be cured by conservative treatments. It well known that oxidative stress, inflammation and neovascularization are main causes corneal damage after but its underlying mechanism remains elucidated. Here, we reported expression phosphorylation (Ser616) mitochondrial fission protein Drp1 were up-regulated at day 3 while fusion Mfn2 was down-regulated. The ERK1/2 in corneas increased 1, 3, 7 peaked burn. In human...
Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin a standard chemotherapeutic reagent for GC treatment. However, chemoresistance an inherent challenge which limits its application effectiveness in clinic. This study aims to investigate mechanism metformin-induced resistance GC. Intriguingly, upregulation mitophagy markers, mitochondrial fission, autophagy mitophagosome were observed SGC-7901/DDP cells compared those SGC-7901 cells. Treatment with metformin...
Age-related macular degeneration (AMD) is the leading cause of vision loss among elderly, which primarily attributed to oxidative stress-induced damage retinal pigment epithelium (RPE). Human amniotic mesenchymal stem cells (hAMSC) were considered be one most promising for clinical application due their low immunogenicity, tissue repair ability, pluripotent potential and potent paracrine effects. The conditional medium (hAMSC-CM) exosomes (hAMSC-exo) derived from hAMSC, as mediators...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent hepatic in the world. Disorders of branched chain amino acid (BCAA) metabolism involved various diseases. In this study, we aim to explore role BCAA development NAFLD and protective effect BCATc Inhibitor 2, an inhibitor cytosolic transaminase, against as well its underlying mechanism. It was found that oleic induced lipid accumulation apoptosis HepG2 LO2 cells. Supplementation BCAAs further aggravated acid-induced apoptosis. contrast,...
Abstract Photothermal therapy (PTT) and photodynamic (PDT) are effective method for tumor treatment. However, the limited variety quantity of photothermal agents (PTAs) photosensitizer (PSs) still major challenges. Moreover, cell apoptosis mechanism induced by PDT PTT is elusive. A fused-ring small molecule acceptor–donor acceptor′ donor–acceptor (A-DA′D-A) type Y5 (Scheme 1) has a narrow band-gap strong light absorption. Herein, we used to polymerize with thiophene unit obtain polymer PYT...
Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability survival rates; however, to be effective, it must given within 4.5 h onset. Moreover, thrombolytic frequently contraindicated. Therefore, alternative therapeutic options are required. In China, cinepazide maleate injection has been shown improve the cerebral collateral circulation further reduce in patients; very few studies investigating this have conducted date. study aimed confirm...
Background: The discrimination of tuberculous meningitis and bacterial remains difficult at present, even with the introduction advanced diagnostic tools. This study aims to differentiate these two kinds by using rule clinical laboratory features. Methods: A prospective observational was conducted collect parameters patients or meningitis. Logistic regression used define formula for receiver operator characteristic curve established determine best cutoff point formula. Results: Five...
The human eye is susceptible to various disorders that affect its structure or function, including glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Mitochondrial dysfunction has been identified as a critical factor in the pathogenesis progression of disorders, making it potential therapeutic target clinic. Natural products have used traditional medicine for centuries continue play significant role modern drug development clinical therapeutics. Recently, there...
Alzheimer's disease (AD), one of the most common types chronic neurodegenerative diseases, is pathologically characterized by formation amyloid β (Aβ) peptide‑containing plaques and neurofibrillary tangles. Among Aβ peptides, Aβ1‑42 induces neuronal toxicity neurodegeneration. In our previous studies, Cdk5 was found to regulate Aβ1‑42‑induced mitochondrial fission via phosphorylation dynamin‑related protein 1 (Drp1) at Ser579. However, whether blockage Drp1 Ser579 protects neurons against...
Digital twin represents the core technology to realize dynamic monitoring of complex industrial systems. However, human body, as most system in physical world, digital is rarely applied it. In this study, we successfully demonstrated a biomedical application by proposing upper limb force. system, real drives motion virtual one real-time and dynamically updates Meanwhile, feeds back monitoring-results force controller
<p indent="0mm">Cisplatin resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC). p32 and OPA1 are key regulators mitochondrial morphology function. This study aims to investigate role p32/OPA1 axis cisplatin NSCLC its underlying mechanism. The levels protein fusion higher cisplatin-resistant A549/DDP cells than cisplatin-sensitive A549 cells, which facilitates cells. In addition, expression also upregulated during development resistance. Moreover,...