A5100454845- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- Plant and Fungal Interactions Research
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Transplantation: Methods and Outcomes
- Neurological Disease Mechanisms and Treatments
- Carcinogens and Genotoxicity Assessment
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and genetic disorders
- Neurogenesis and neuroplasticity mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Autophagy in Disease and Therapy
- Connective Tissue Growth Factor Research
Harbin Medical University
2017-2023
First Affiliated Hospital of Harbin Medical University
2017-2023
Heilongjiang Academy of Sciences
2023
Tangshan People's Hospital
2021
China Medical University
2009-2021
Ministry of Education of the People's Republic of China
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Huzhou Central Hospital
2018
Guilin Medical University
2018
First Affiliated Hospital of Zhengzhou University
2017
Objective Diffuse alveolar hemorrhage (DAH) is a rare but life‐threatening complication of systemic lupus erythematosus (SLE). Pristane‐treated B6 mice develop severe DAH within 2 weeks treatment. MicroRNA‐155 (miR‐155) pleiotropic microRNA that plays crucial role in the regulation immune responses. Recent studies have revealed pathogenic miR‐155 various autoimmune disorders. The purpose this study was to examine development pristane‐induced using miR‐155–knockout (miR‐155 −/− ) and...
Dishevelled (Dvl) family proteins are overexpressed in nonsmall cell lung cancer (NSCLC), but the correlation between Dvl overexpression and patient prognosis is not clear. The underlying mechanisms of Dvl-1 Dvl-3 promoting invasion require further research. We used immunohistochemistry to assess presence Dvl-1, Dvl-3, β-catenin, p120ctn, compared their expression 102 specimens from NSCLC patients. also examined effect on Tcf-dependent transcriptional activity, as well invasiveness A549...
AIMTo investigate the potential role of microRNA-30a (miR-30a) in esophageal squamous cell carcinoma (ESCC).
CRKL is recently defined as a new oncogene, which plays role in the lung cancer progression. However, potential mechanism of human non-small cell invasion obscure. We investigated using immunohistochemistry, plasmid transfection, Western blotting, real-time PCR, matrigel assay, chromatin immunoprecipitation and luciferase reporter assay. expression higher lymph node metastatic tumor compared with primary tumor. overexpression enhanced MMP9 both HBE H1299 lines. There was significant...
Abstract Cystatin SN, a specific cysteine protease inhibitor, is thought to be involved in various malignant tumors. Therefore, we evaluated the role of cystatin SN hepatocellular carcinoma (HCC). Notably, was elevated tumorous samples and cells. Moreover, overexpression correlated with tumor diameter TNM stage. Cox multivariate analysis displayed that an independent prognosis indicator high level associated dismal prognosis. enhancement facilitated proliferation, migratory, invasive...
In this study, we investigated the role of microRNA-644a (miR-644a) in growth and survival hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower HCC tissues than adjacent peri-cancerous (n = 135). expression was inversely correlated with heat shock factor 1 (HSF1) expression, tumour diameter TNM stage. Moreover, HepG2 SMMC-7721 cell lines showed miR-644a normal L-O2 hepatocytes. overexpression cells increased apoptosis by downregulating HSF1. Dual luciferase reporter assays...
Fanconi anemia complementation group-F (FANCF) is a key factor to maintain the function of FA/BRCA, DNA-damage response pathway. However, functional role FANCF in breast cancer has not been elucidated. In this study, we examined effects and mechanisms FANCF-RNAi on sensitivity cells mitoxantrone (MX). silencing by FANCF-shRNA blocked functions FA/BRCA pathway through inhibition FANCD2 mono-ubiquitination cell lines MCF-7 T-47D. addition, shRNA inhibited proliferation, induced apoptosis,...
Gastric cancer (GC) is associated with poor patient prognosis, and so it crucial to investigate the molecular mechanisms underlying progression of GC. The aim present study was role transmembrane-4 L6 family member 1 (TM4SF1) in TM4SF1 small interfering RNA (siRNA) TM4SF1-expressing plasmids were employed regulate expression. In vitro experiments performed determine effect on expression apoptosis-associated molecules apoptosis, proliferation, migration invasion using human GC cell lines...
The deregulation of long non-coding RNAs (lncRNAs) by epigenetic alterations has been implicated in cancer initiation and progression. However, the epigenetically regulated lncRNAs their association with clinical outcome therapeutic response ovarian (OV) remain poorly investigated. This study performed an integrative analysis DNA methylation data transcriptome identified 419 as potential lncRNAs. Using machine-learning multivariate Cox regression methods, we developed lncRNA expression...
To determine the mechanism that long noncoding RNA NEAT1 (lncNEAT1)/miR-320a competitive endogenous (ceRNA) network regulates hypoxia-inducible factor-1α (HIF-1α) in ARPE-19 cells and its potential role diabetic retinopathy (DR).ARPE-19 were cultured a normal or high-glucose (HG) medium, cell migration, invasion, permeability detected by scratch, transwell, FITC-dextran staining assays. LncNEAT1, HIF-1α, ZO-1, occludin, N-cadherin, vimentin levels tested. The binding of lncNEAT1 to miR-320a...
Melanoma is a rare but fatal form of skin cancer and acral lentiginous melanoma (ALM) one its the most common types. Long non‑coding RNA (lncRNA) has emerged as crucial molecule in development progression human cancers, several studies have revealed that lncRNAs may be associated with pathogenesis, metastasis melanoma. To demonstrate association between ALM lncRNAs, microarray analysis was performed tumor adjacent non‑tumor tissues. A total 4,488 3,913 mRNAs were identified to differentially...