A5004351194- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Retinal Development and Disorders
- Hedgehog Signaling Pathway Studies
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Retinal Diseases and Treatments
- Developmental Biology and Gene Regulation
- Renal and related cancers
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Immune cells in cancer
- Nerve injury and regeneration
- Photoreceptor and optogenetics research
- Adenosine and Purinergic Signaling
Guangdong Ocean University
2025
Sichuan University
2020-2023
Xijing Hospital
2017-2023
The University of Texas Southwestern Medical Center
2011-2022
Cleveland Clinic
2005-2022
Army Medical University
2022
Xinqiao Hospital
2022
Air Force Medical University
2008-2020
Cleveland Clinic Lerner College of Medicine
2018-2020
Case Western Reserve University
2018-2020
We report the cDNA cloning of SREBP-2, second member a family basic-helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors that recognize sterol regulatory element 1 (SRE-1). SRE-1, conditional enhancer in promoters for low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A synthase genes, increases absence sterols is inactivated when accumulate. Human SREBP-2 contains 1141 amino acids 47% identical to human SREBP-1a, first recognized this family. The...
Mammalian SWI/SNF [also called BAF (Brg/Brahma-associated factors)] ATP-dependent chromatin remodeling complexes are essential for formation of the totipotent and pluripotent cells early embryo. In addition, subunits this complex have been recovered in screens genes required nuclear reprogramming Xenopus mouse embryonic stem cell (ES) morphology. However, mechanism underlying roles these is unclear. Here, we show that self-renewal pluripotency ES but not proliferation fibroblasts or other...
Proteomic diversity is frequently achieved by alternative RNA-splicing events that can be fine-tuned in tissue-specific and developmentally regulated ways. Understanding this type of genetic regulation compelling because the extensive complexity splicing found nervous system. quaking ( qk ), one classical mouse dysmyelination mutants, defective for expression myelin-associated glycoprotein (MAG), misregulation MAG pre-mRNA implicated as a causal factor. The locus encodes several RNA-binding...
Mutations in VMD2, encoding bestrophin (best-1), cause Best vitelliform macular dystrophy (BMD), adult-onset (AVMD), and autosomal dominant vitreoretinochoroidopathy (ADVIRC). BMD is distinguished from AVMD by a diminished electrooculogram light peak (LP) the absence of changes flash electroretinogram. Although LP thought to be generated best-1, we find enhanced luminance responsiveness with normal amplitude Vmd2−/− mice no differences cellular Cl− currents comparison Vmd2+/+ littermates....
The mouse quaking (qk) gene is essential in both myelination and early embryogenesis. Its product, QKI, an RNA-binding protein belonging to a growing family called STAR (signal transduction andactivator of RNA). All members have ∼200-amino acid domain, which contains single extended heteronuclear ribonucleoprotein K homologue domain flanked by two domains QUA1 QUA2. We found that QKI isoforms could associate with each other, while one the lethal mutationsqkI kt4 amino change leads loss...
Mutations in BEST1, encoding bestrophin-1 (Best1), cause Best vitelliform macular dystrophy (BVMD), a dominantly inherited degeneration characterized by diminished electrooculogram light peak (LP), lipofuscin retinal pigment epithelial cells (RPE), and fluid- debris-filled detachments. To understand the pathogenesis of BVMD we generated knock-in mice carrying BVMD-causing mutation W93C Best1. Both Best1(+/W93C)and Best1(W93C/W93C) had normal ERG a- b-waves, but exhibited an altered LP...
Sonic hedgehog (Shh) signaling plays diverse roles during animal development and adult tissue homeostasis through differential regulation of Gli family transcription factors. Dysregulated Shh activities have been linked to birth defects tumorigenesis. Here we report that Brg, an ATP-dependent chromatin remodeling factor, has dual functions in regulating target gene expression. Using a Brg conditional deletion Shh-responding neural progenitors fibroblasts, demonstrate is required both for...
Previous studies in mice have demonstrated that Rhodotorula mucilaginosa ZTHY2 can promote animal growth, enhance antioxidant and immune functions, regulate intestinal flora our laboratory. This study focuses on the Leizhou black duck, a local breed Zhanjiang, to evaluate effects of its capacity, function. A total 150 1-day-old male ducks, similar size healthy, were selected for this randomly assigned five treatment groups. Each group contained three replicates with ten birds each. The...
In response to light, the mouse retinal pigment epithelium (RPE) generates a series of slow changes in potential that are referred as c-wave, fast oscillation (FO), and light peak (LP) electroretinogram (ERG). The LP is generated by depolarization basolateral RPE plasma membrane activation calcium-sensitive chloride conductance. We have previously shown reduced both mice rats nimodipine, which blocks voltage-dependent calcium channels (VDCCs) abnormal lethargic mice, carrying null mutation...
In the developing peripheral nervous system, axon-derived signals stimulate Schwann cells to undergo a global genetic reprogramming involving cessation of cellular division and upregulation myelin genes. How such comprehensive change in gene transcription is regulated poorly understood. Here we report that BRG1/SMARCA4, central helicase mammalian SWI/SNF-related chromatin remodeling complex, required for differentiate form myelin, both vitro vivo , mouse. BRG1 was highly activated at early...