A5101856043- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Caveolin-1 and cellular processes
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Migraine and Headache Studies
- Lipid metabolism and disorders
- Transcranial Magnetic Stimulation Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Extracellular vesicles in disease
- Barrier Structure and Function Studies
- Apelin-related biomedical research
- S100 Proteins and Annexins
- Heart Rate Variability and Autonomic Control
- Blood Coagulation and Thrombosis Mechanisms
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Atherosclerosis and Cardiovascular Diseases
Nanjing University
2015-2024
Nanjing General Hospital of Nanjing Military Command
2015-2024
Nanjing Medical University
2015-2024
Xinqiao Hospital
2019
Army Medical University
2019
117th Hospital of People's Liberation Army
2019
University of Science and Technology of China
2019
Sir Run Run Shaw Hospital
2019
Zhejiang University
2019
Southeast University
2019
Abstract Ischemic stroke can cause secondary myelin damage in the white matter distal to primary injury site. The contribution of astrocytes during demyelination and underlying mechanisms are unclear. Here, using a mouse middle cerebral artery occlusion, we show that lipocalin-2 (LCN2), enriched reactive astrocytes, expression increases nonischemic areas corpus callosum upon injury. LCN2-expressing acquire phagocytic phenotype able uptake myelin. Myelin removal is impaired Lcn2 −/−...
The neutrophil to lymphocyte ratio (NLR) has been shown predict short- and long-term outcomes in ischemic stroke patients. We sought explore the temporal profile of plasma NLR patients treated with intravenous thrombolysis (IVT) its relationship intracranial bleeding complications after thrombolysis.A total 189 were prospectively enrolled. Blood samples for leukocyte, neutrophil, counts obtained at admission 3-6, 12-18, 36-48 h IVT. Head CT was performed on repeated h, a scan done...
Thrombo-inflammation is an important checkpoint that orchestrates infarct development in ischemic stroke. However, the underlying mechanism remains largely unknown. Here, we explored role of endothelial Caveolin-1 (Cav-1) cerebral thrombo-inflammation.The correlation between serum Cav-1 level and clinical outcome was analyzed acute stroke patients with successful recanalization. Genetic manipulations by endothelial-specific adeno-associated virus (AAV) siRNA were applied to investigate...
Objective: Anesthetic preconditioning appears to be a viable strategy treat ischemic cerebral injury. Here we investigated 1) whether the protection conferred by sevoflurane sustains in time; 2) diminishes mitochondrial dysfunction following ischemia; and 3) permeability transition pore plays crucial role preconditioning. Design: Laboratory investigation. Setting: University research laboratory. Subjects: Sprague-Dawley rats. Interventions: Rats underwent 2 hrs of focal ischemia induced...
Objective: Subarachnoid hemorrhage results in significant long-lasting neurologic sequelae. Here, we investigated whether human albumin improves long-term outcomes experimental subarachnoid and neurovascular remodeling is involved the protection of albumin. Design: Laboratory investigation. Setting: Hospital research laboratory. Subjects: Male Sprague-Dawley rats. Interventions: Rats underwent by endovascular perforation. Albumin either 0.63 or 1.25 g/kg was injected IV immediately after...
Astrocytes, the most numerous cells in human brain, play a central role metabolic homeostasis following hypoxic injury. Caveolin-1 (Cav-1), transmembrane scaffolding protein, has been shown to converge prosurvival signaling nerve system. The present study aimed investigate of Cav-1 hypoxia-induced astrocyte We also examined how alleviates apoptotic death. To this end, primary astrocytes were exposed oxygen-glucose deprivation (OGD) for 6 h and subsequent 24-h reoxygenation mimic OGD...
Abstract Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse bilateral carotid artery stenosis, we show gradual accumulation OPCs vasculature with impaired oligodendrogenesis. Mechanistically, ischemia induces substantial loss endothelial caveolin-1 (Cav-1), leading secretion heat shock protein 90α...
Importance In several randomized clinical trials, endovascular thrombectomy led to better functional outcomes than conventional treatment at 90 days poststroke in patients with acute basilar artery occlusion. However, the long-term of these have not been well delineated. Objective To evaluate 1-year occlusion following vs control. Design, Setting, and Participants This study is an extension ATTENTION trial, a multicenter, trial. Patients were included between February 2021 January 2022,...
Objective: To compare the efficacy of body posture combined with pharmacotherapy and alone in treatment chronic subdural hematoma(CSDH). Methods: Firstly, retrospective case series study was conducted. Thirty cases CSDH that had received at Department Neurosurgery, Huashan Hospital Affiliated to Fudan University were studied retrospectively. Twenty-seven patients male, 3 female. The age (M(IQR)) 66(16) years (range:28 84). Nineteen unilateral hematoma, 11 bilateral hematoma. All therapy...
Oligodendrocytes express low-density lipoprotein receptor (LDLR) to endocytose cholesterol for the maintenance of adulthood myelination. However, potential role LDLR in chronic cerebral ischemia-related demyelination remains unclear. We used bilateral carotid artery stenosis (BCAS) induce sustained ischemia mice. This hypoxic-ischemic injury caused a remarkable decrease oligodendroglial LDLR, with impaired differentiation and survival. Oligodendroglial levels, however, remained unchanged....
Objective To compare the effects of high-frequency (10 Hz) versus low-frequency (1 repetitive Transcranial Magnetic Stimulation (rTMS) on motor recovery and functional reorganization cortical network during early phase stroke. Methods Forty-six hospitalized, first-ever ischemic stroke patients in stage (within two weeks) with upper limb deficits were recruited. They randomly allocated to three groups 10 Hz ipsilesional rTMS, 1 contralesional sham rTMS five daily session. All underwent...
Background Allocation of health research funds among diseases has never been evaluated in China. This study aimed to examine the relationship between disease-specific funding levels National Nature Science Foundation China (NSFC), main governmental resource for China, and burden disease. Methods Funding magnitudes 53 or conditions were obtained from website NSFC. Measures disease burden, mortality, years life lost (YLLs) disability-adjusted (DALYs), derived Global Burden Disease Study 2010....
Abstract Bradykinin receptors play important roles in cerebral ischaemia–reperfusion (I/R) injury of non‐diabetics. Their functions diabetics, however, have not been studied. In this study, we hypothesized that bradykinin 1 receptor (B1R) and 2 (B2R) would be upregulated participate the regulation diabetic ischaemic stroke. To investigate this, first evaluated B1R B2R expression at different time points after I/R non‐diabetic rats (Sprague–Dawley) by using real‐time quantitative reverse...