A5100770585- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Pathogens and Fungal Diseases
- Inflammasome and immune disorders
- Hippo pathway signaling and YAP/TAZ
- Genomics, phytochemicals, and oxidative stress
- Plant Disease Resistance and Genetics
- Acute Ischemic Stroke Management
- Inflammation biomarkers and pathways
- Plant Physiology and Cultivation Studies
- Cancer-related gene regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Plant Pathogens and Resistance
- Genetics, Aging, and Longevity in Model Organisms
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Vestibular and auditory disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Memory and Neural Mechanisms
- Neurosurgical Procedures and Complications
- Cancer-related molecular mechanisms research
- Microfluidic and Capillary Electrophoresis Applications
State Key Laboratory of Transducer Technology
2024
Chinese Academy of Sciences
2024
Shanghai Institute of Microsystem and Information Technology
2024
Nanjing Medical University
2018-2023
Second Military Medical University
2020-2023
Changhai Hospital
2020-2023
Huazhong University of Science and Technology
2023
Qilu Hospital of Shandong University
2023
Jiangsu Province Hospital
2023
Shandong University
2022
Abstract Neuroinflammation is initiated in response to ischemic stroke, generally with the hallmarks of microglial activation and collateral brain injury contributed by robust inflammatory effects. Triggering receptor expressed on myeloid cells (TREM)-1, an amplifier innate immune response, a critical regulator inflammation. This study identified that TREM-1 expression was upregulated following cerebral injury. After pharmacologic inhibition synthetic peptide LP17, ischemia-induced...
Neuroinflammation is a vital pathophysiological process during ischemic stroke. Activated astrocytes play major role in inflammation. Lipocalin-2 (LCN2), secreted by activated astrocytes, promotes neuroinflammation. Pyroptosis pro-inflammatory form of programmed cell death that has emerged as new area research Nevertheless, the potential LCN2 astrocyte pyroptosis remains unclear.An stroke model was established middle cerebral artery occlusion (MCAO) vivo. In this study, vitro, oxygen-glucose...
Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment for ischemic stroke. Astrocytes regulation has been suggested as one mechanism rTMS effectiveness. But how regulates astrocytes remains largely undetermined. There were neurotoxic and neuroprotective phenotypes of (also denoted classically alternatively activated or A1 A2 astrocytes) pertaining to pro- anti-inflammatory gene expression. Pro-inflammatory polarized induced during cerebral The...
Cellular oxidative stress plays a vital role in the pathological process of neural damage cerebral ischemia/reperfusion (I/R). The breast cancer susceptibility protein 1 (BRCA1), tumor suppressor, can modulate cellular antioxidant response and DNA repair. Yet BRCA1 I/R injury has not been explored. In this study, we observed that was mainly expressed neurons up-regulated to insult. Overexpression attenuated reactive oxygen species production lipid peroxidation. Enhanced expression promoted...
Abstract Hippocampal circuitry stimulation is sufficient to regulate adult hippocampal neurogenesis and ameliorate depressive‐like behavior, but its underlying mechanism remains unclear. Here, it shown that inhibition of medial septum (MS)‐dentate gyrus (DG) circuit reverses the chronic social defeat stress (CSDS)‐induced depression‐like behavior. Further analysis exhibits gamma‐aminobutyric acidergic neurons in MS projecting DG (MS GABA+ ‐DG) increases expression platelet‐derived growth...
To compare survival outcomes and acute toxicities between daytime evening radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC). We enrolled 1351 NPC who received definitive RT the (before 16:00; n = 625) or (after 726) 2015 2016. Optimal cutoff time was determined by receiver operating characteristic analysis. Survival were compared groups before after propensity score matching (PSM). Multivariate Cox analyses performed to identify independent prognostic factors. With a median...
Abstract Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment progestin, and its underlying mechanisms remain unclear. YAP TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway, promote viability, metastasis also drug malignant tumors. According to our microarray analysis, YAP/TAZ were upregulated in progestin resistant IshikawaPR cell versus sensitive Ishikawa cell, which implied that may be vital promotor...
Oligodendrocytes express low-density lipoprotein receptor (LDLR) to endocytose cholesterol for the maintenance of adulthood myelination. However, potential role LDLR in chronic cerebral ischemia-related demyelination remains unclear. We used bilateral carotid artery stenosis (BCAS) induce sustained ischemia mice. This hypoxic-ischemic injury caused a remarkable decrease oligodendroglial LDLR, with impaired differentiation and survival. Oligodendroglial levels, however, remained unchanged....
When brain injury happens, endogenous neural stem cells (NSCs) located in the adult subventricular zone (SVZ) and subgranular (SGZ) are attacked by ischemia/reperfusion to undergo cellular apoptosis death before being induced migrate lesion point differentiate into mature for damaged cell replacement. Although promoting antiapoptosis NSC survival critical neuroregeneration, mechanism has yet been elucidated clearly. Here this study, we established an vitro oxygen‐glucose deprivation...
Radiation and cisplatin-based chemotherapy are major treatments for nasopharyngeal carcinoma (NPC). However, a impediment further improving the cure rate is development of treatment resistance with an undetermined molecular mechanism in metastatic NPC cells. Our established, highly cells have been reported to be more resistant cisplatin chemotherapy. In present study, we found that Ras association domain family member 6 (RASSF6) was downregulated but upregulated low comparison their parental...
The incidence and mortality of cervical cancer (CC) rank fourth among those all gynecological malignancies. Long noncoding RNAs (lncRNAs) serve important roles in the development various types cancer. aim present study was to explore role lncRNAs pathogenesis CC identify novel therapeutic targets. LINC01012 identified be associated with an unfavorable prognosis patients based on bioinformatics analyses. Upregulated expression further verified samples intraepithelial neoplasia grade 3 tissues...
Background Preoperative neuroimaging assessment of collateral circulation is important for selecting acute ischemic stroke patients who are appropriate endovascular treatment. We sought to validate the capillary index score system in an Asian population and compare its ability predicting clinical outcomes with American Society Interventional Therapeutic Neuroradiology/Society Radiology grading system. Methods continuously enrolled from two neurological centers March 2014 2017. Multivariate...
Abstract Background: Neuroinflammation has been recognized as vital pathophysiological process during ischemic stroke. Activated astrocytes play a major role in inflammatory response. Lipocalin-2 (LCN2), secreted from activated astrocytes, promotes neuroinflammation. Pyroptosis, pro-inflammatory programmed cell death, is emerging new area of research on Nevertheless, the potential LCN2 astrocyte pyroptosis remains unclear. Methods: Ischemic stroke model was established by middle cerebral...
Objective To investigate the capillary index score (CIS) and clinical outcome after endovascular treatment in patients with anterior circulation acute ischemic stroke (AIS). Methods From March 2014 to 2017, AIS received Jinling Hospital Wuhu Yijishan were enrolled retrospectively. The data of intraoperative digital subtraction angiography collected CIS was calculated. They divided into either a poor group (score 0-1) or good (scores 2-3). Univariate analysis used compare baseline...
Abstract Background: Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment progestin, and its underlying mechanisms remain unclear. YAP TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway, are highly expressed induce aggressive phenotypes EC. However, the role YAP/TAZ in progestin EC still unknown. The aim this study to explore functions Methods: expression resistant tissues was examined by immunohistochemistry. We...