A5101691930- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Therapy and Dosimetry
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Inflammasome and immune disorders
- Peripheral Artery Disease Management
- Thyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- interferon and immune responses
- Neurological Disease Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA Research and Splicing
- Retinal and Optic Conditions
- Alzheimer's disease research and treatments
- Aquaculture disease management and microbiota
- Macrophage Migration Inhibitory Factor
Shuguang Hospital
2020-2025
Shanghai University of Traditional Chinese Medicine
2020-2025
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2024-2025
Institute of Microbiology
2023-2024
Chinese Academy of Sciences
2023-2024
Harbin Medical University
2024
Xinxiang Central Hospital
2007-2024
Northeast Normal University
2024
Tianjin University
2024
Background: The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO). Methods: present analysis was based on ongoing, prospective, multicenter ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) trial registry China. Our analytic sample comprised 2134 patients recruited at 48 sites between 2017 2021 included 462 who received BMM 1672 EVT. We performed...
Symptomatic intracranial hemorrhage (sICH), potentially associated with poor prognosis, is a major complication of endovascular thrombectomy (EVT) for ischemic stroke patients. We aimed to develop and validate risk model predicting sICH after EVT in Chinese patients due large-artery occlusions the anterior circulation.The derivation cohort recruited from Endovascular Treatment Acute Anterior Circulation Ischemic Stroke Registry China. was diagnosed according Heidelberg Bleeding...
Hyperglycemia has been associated with unfavorable outcome of acute ischemic stroke, but this association not verified in patients endovascular thrombectomy treatment. This study aimed to assess the impact stress hyperglycemia ratio on early neurological deterioration and favorable after stroke.Stroke two comprehensive centers were enrolled. Early was defined as ≥4 points increase National Institutes Health Stroke Scale (NIHSS) at 24 hours procedure. Favorable modified Rankin (mRS) score 0-2...
This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on integumentary, respiratory, cardiovascular, urinary, and skeletal systems, study highlights versatility MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge central mediators antioxidative anti-inflammatory effects. From expediting diabetic wound healing to...
Nerve growth factor (NGF) has been proved with the potential of promoting neurogenesis in adult mammalians. This study was aimed to investigate effect intranasal (IN) NGF on striatal and functional recovery rats focal cerebral ischemia. Rats were subjected middle artery occlusion (MCAO) for 2 h, then reperfused. or vehicle intranasally administered 24 h after reperfusion, treatments continued 6 consecutive days there after. All animals injected 5-bromodeoxyuridine (BrdU) twice daily 5-7...
<h3>Objective</h3> To investigate whether thyroid function profiles can predict poststroke fatigue (PSF) in patients with acute ischemic stroke. <h3>Methods</h3> Patients stroke were consecutively recruited within 3 days of onset Jinling Hospital. Serum levels hormones, antibodies, hematologic indexes, and biochemical indexes measured on admission. Fatigue was scored using the Severity Scale. Associations analyzed multivariate regression restricted cubic splines. <h3>Results</h3> Of 704...
Background The trajectory of ischemic stroke patients attributable to large vessel occlusion is fundamentally altered by endovascular thrombectomy. This study aimed develop a nomogram for predicting 3-month mortality risk in with attributed artery anterior circulation who received successful thrombectomy treatment. Methods and Results Patients (modified Thrombolysis Cerebral Infarction IIb or III) were enrolled from multicenter registry as the training cohort. Step-wise logistic regression...
Abstract The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level MPXV B6 protein in vaccinia vaccinees born before end immunization program and then identified two monoclonal antibodies (MAbs), hMB621 hMB668, targeting distinct epitopes on B6, from one vaccinee. Binding assays demonstrate that both MAbs exhibit broad binding abilities its orthologs (VACV), variola (VARV)...
Modern cancer treatment techniques, such as intensity-modulated radiation therapy (IMRT) and stereotactic body (SBRT), have greatly increased the demand for more accurate planning (structure definition, dose calculation, etc) delivery. The ability to use fast Monte Carlo (MC)-based calculations within a commercial system (TPS) in clinical setting is now becoming of reality. This study describes dosimetric verification initial evaluation new MC-based photon beam calculation algorithm, iPlan...
Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine-tuned by dynamic ubiquitination deubiquitination processes. In this study, we report ubiquitin-specific protease (USP) 15 is involved in regulation retinoic acid-inducible gene (RIG-I)-dependent...
Objective To explore the clinical utility of metagenomic next-generation sequencing (mNGS) in diagnosing invasive pulmonary aspergillosis (IPA) among patients with acute exacerbation chronic obstructive disease (AECOPD) intensive care unit (ICU). Methods A retrospective analysis was conducted on AECOPD admitted to ICU Xinxiang Central Hospital Henan Province, China, between March 2020 and September 2023, suspected having IPA. Bronchoalveolar lavage fluid (BALF) samples were collected for...
OBJECTIVE Endovascular treatment (EVT) is an effective for patients with acute vertebrobasilar artery complex occlusion (VBAO). However, the benefit of bridging thrombolysis prior to EVT remains controversial. The purpose present study explore best strategy between (BT) and direct in VBAO. METHODS Patients VBAO who underwent within 24 hours estimated a nationwide retrospective registry at 65 stroke centers 15 provinces China from December 2015 June 2022 were retrospectively analyzed....
Background and Purpose— In acute arterial occlusion, fluid-attenuated inversion recovery vascular hyperintensity (FVH) has been linked to slow flow in leptomeningeal collaterals cerebral hypoperfusion, but the impact on clinical outcome is still controversial. this study, we aimed investigate association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern M1-middle artery occlusion patients with endovascular treatment. Methods— We included treated therapy...
Malnutrition is highly prevalent in ischemic stroke patients. We aimed to investigate whether malnutrition indexes may be useful predicting mortality at 90 days patients treated with intravenous thrombolysis.We retrospectively analyzed consecutive who underwent thrombolytic therapy three comprehensive centers. was assessed using the controlling nutritional status (CONUT) score, geriatric risk index (GNRI), and prognostic (PNI).Of 979 (mean age, 66.8 years; males, 63.6%) included this study,...
The cone-beam computed tomography (CBCT) imaging modality is an integral component of image-guided adaptive radiation therapy (IGART), which uses patient-specific dynamic/temporal information for potential treatment plan modification. In this study, offline process the IGART framework has been implemented that consists deformable image registration (DIR) and its validation, dose reconstruction, accumulation verification. This study compares differences between planned estimated delivered...
Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of treatment remains limited due an inherent tumor resistance DDP. Genistein (GEN) is abundant, naturally occurring isoflavonoid found in soy products that demonstrated increase anti-neoplastic activity certain chemotherapy drugs multiple types. In present study, DDP combination with GEN was selected as potential suppress growth and simultaneously reduce...
Oligodendrocytes express low-density lipoprotein receptor (LDLR) to endocytose cholesterol for the maintenance of adulthood myelination. However, potential role LDLR in chronic cerebral ischemia-related demyelination remains unclear. We used bilateral carotid artery stenosis (BCAS) induce sustained ischemia mice. This hypoxic-ischemic injury caused a remarkable decrease oligodendroglial LDLR, with impaired differentiation and survival. Oligodendroglial levels, however, remained unchanged....