A5055219100- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Bacillus and Francisella bacterial research
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Protein Hydrolysis and Bioactive Peptides
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Plant Gene Expression Analysis
- Plant Virus Research Studies
- Meat and Animal Product Quality
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Plant Pathogens and Resistance
- Wnt/β-catenin signaling in development and cancer
- Hepatitis Viruses Studies and Epidemiology
- Plant Stress Responses and Tolerance
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Animal Disease Management and Epidemiology
- RNA and protein synthesis mechanisms
Peking University
2024-2025
Beijing Academy of Science and Technology
2024
China Agricultural University
2019-2023
Chinese Academy of Sciences
2011-2020
Institute of Microbiology
2018-2020
Wuhan Institute of Virology
2012
Shanghai Institutes for Biological Sciences
2011
Center for Excellence in Molecular Plant Sciences
2011
The WRKY transcription factor (TF) gene family expanded greatly in the evolutionary process from green algae to flowering plants through whole genome, segmental, and tandem duplications. Genomic sequences diverse plant species provide valuable information about origin evolution of domain-containing proteins. Accumulating data indicate that TFs bind W-box and/or other cis-elements, revealing specificity cis-element recognition based on structure protein as well nucleotides adjacent core...
Abstract Background Non-coding small RNAs play critical roles in various cellular processes a wide spectrum of eukaryotic organisms. Their responses to abiotic stress have become popular topic economic and scientific importance biological research. Several studies recent years reported number non-coding that map chloroplast genomes. However, it remains uncertain whether are generated from genome how they respond environmental stress, such as high temperature. Chinese cabbage is an important...
Abstract The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level MPXV B6 protein in vaccinia vaccinees born before end immunization program and then identified two monoclonal antibodies (MAbs), hMB621 hMB668, targeting distinct epitopes on B6, from one vaccinee. Binding assays demonstrate that both MAbs exhibit broad binding abilities its orthologs (VACV), variola (VARV)...
Leaf heads of cabbage (Brassica oleracea), Chinese (B. rapa), and lettuce (Lactuca sativa) are important vegetables that supply mineral nutrients, crude fiber vitamins in the human diet. Head size, head shape, weight, heading time contribute to yield quality. In an attempt investigate genetic basis leafy we took advantage recent technical advances genome resequencing perform quantitative trait locus (QTL) mapping using 150 recombinant inbred lines (RILs) derived from cross between...
The Mpox virus (MPXV) is an orthopoxvirus that caused a global outbreak in 2022. poxvirus DNA polymerase complex responsible for the replication and integrity of viral genome; however, molecular mechanisms underlying fidelity are still unclear. In this study, we determined cryoelectron microscopy (cryo-EM) structures MPXV F8-A22-E4 holoenzyme its editing state, with mismatched primer-template containing uracil deoxynucleotide. We showed has similar replication-to-edit transition mechanism to...
African swine fever virus (ASFV) is a highly contagious nucleocytoplasmic large DNA (NCLDV) that causes nearly 100% mortality in swine. The development of effective vaccines and drugs against this urgently needed. pA104R, an ASFV-derived histone-like protein, shares sequence functional similarity with bacterial HU/IHF family members essential for viral replication. Herein, we solved the crystal structures pA104R its apo state as well complex DNA. Apo-pA104R forms homodimer folds into...
ABSTRACT Rotaviruses (RVs), which cause severe gastroenteritis in infants and children, recognize glycan ligands a genotype-dependent manner via the distal VP8* head of spike protein VP4. However, binding mechanisms remain elusive for P[II] genogroup RVs, including widely prevalent human RVs (P[8], P[4], P[6]) rare P[19] RV. In this study, we characterized specificities porcine P[6]/P[19] RV VP8*s found that could commonly interact with mucin core 2, may play an important role evolution...
Abstract The African swine fever virus (ASFV) type II topoisomerase (Topo II), pP1192R, is the only known Topo expressed by mammalian viruses and essential for ASFV replication in host cytoplasm. Herein, we report structures of pP1192R various enzymatic stages using both X-ray crystallography single-particle cryo-electron microscopy. Our data structurally define pP1192R-modulated DNA topology changes. By presenting A2+-like metal ion at pre-cleavage site, pP1192R–DNA–m-AMSA complex structure...
Apoptosis in postmortem muscle is a potential factor affecting meat quality. This study aimed to investigate the changes apoptotic genes and proteins, reactive oxygen species (ROS), caspase-3 activity their underlying relationship with tenderization. As time extended, there was significant increase myofibril fragmentation index (MFI) destruction of fibers. Oxidative stress deepened alongside onset apoptosis. Mitochondrial membrane (MMP) decreased, increased during first 24 h postmortem....