A5062319349- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
- EEG and Brain-Computer Interfaces
- Bioinformatics and Genomic Networks
- Racial and Ethnic Identity Research
- Wireless Sensor Networks and IoT
- AI in cancer detection
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Sport Psychology and Performance
- Internet of Things and Social Network Interactions
- Soft Robotics and Applications
- Genetic Associations and Epidemiology
- Advanced Algorithms and Applications
- Stress Responses and Cortisol
- Surgical Simulation and Training
Chung Yuan Christian University
2007-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2018-2023
Shanghai Institute for Science of Science
2019-2023
Fudan University
2018-2023
Shanghai Innovative Research Center of Traditional Chinese Medicine
2022
East China Normal University
2020
Institute of Science and Technology
2019
National Yunlin University of Science and Technology
2008
Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson's disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS in basal ganglia (BG) midbrain early-stage PD. recruited 40 PD patients 41 healthy controls (HCs). Both number volume were calculated evaluate burden 7 T magnetic resonance imaging images. compared between HC, conducted partial correlation analysis features. had a significantly more...
The orbitofrontal cortex (OFC) is implicated in depression. hypothesis investigated was whether the OFC sensitivity to reward and nonreward related severity of depressive symptoms. Activations monetary incentive delay task were measured IMAGEN cohort at ages 14 years (n = 1877) 19 1140) with a longitudinal design. Clinically relevant subgroups compared (high-severity group: n 116; low-severity 206) 14. medial exhibited graded activation increases reward, lateral had nonreward. In this...
Abstract Schizophrenia is characterized by dysconnectivity syndrome. Evidence of widespread impairment structural and functional integration has been demonstrated in schizophrenia. Although white matter (WM) microstructural abnormalities have commonly reported schizophrenia, the dysfunction WM as well relationship between structure function remains uncertain. In this study, we proposed a novel structure-function coupling measurement to reflect neuronal information transfer, which combined...
Abstract Background Although previous studies have demonstrated that the hippocampus plays a role in verbal memory, of hippocampal subfields visual memory is uncertain, especially those with preclinical Alzheimer's disease (AD). This study aimed to examine relationships between subfield volumes and SCD (subjective cognitive decline) aMCI (amnestic mild impairment). Methods The sample included 47 patients, 62 51 normal controls (NCs) was recruited from Shanghai Jiao Tong University Affiliated...
BackgroundSubjective or objective subtle cognitive decline (SCD) is considered the preclinical manifestation of Alzheimer's disease (AD), which a potentially crucial window for preventing delaying progression disease.MethodsTo explore potential mechanism and identify relevant biomarkers, we comprehensively assessed peripheral blood transcriptomic alterations in SCD, covering lncRNA, mRNA, miRNA.FindingsDysregulated protein-coding mRNA at both gene isoform levels implicated impairment type I...
Introduction : To identify individuals with preclinical cognitive impairment, researchers proposed the concept of objectively-defined subtle decline (Obj-SCD). However, it is not clear whether Obj-SCD has characteristic brain function changes. In this study, we aimed at exploring changing pattern activity in and similarities differences mild impairments (MCI). Method 37 healthy control individuals, 25 (with impairment memory language domain), 28 aMCI were included. Resting-state fMRI...
Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 9620 participants, we found that global functional connectivity was stronger in male brain before middle age became weaker after that, when compared female brain, systematic testing of potentially confounding effects. We gender continuum by...
Abstract Nonrapid eye movement (NREM) sleep is associated with fading consciousness in humans. Recent neuroimaging studies have demonstrated the spatiotemporal alterations of brain functional connectivity (FC) NREM sleep, suggesting changes information integration sleeping brain. However, common stationarity assumption FC does not satisfactorily explain dynamic process during sleep. The (dFC) across networks speculated to better reflect time‐varying propagation Accordingly, we conducted...
Dynamical changes have recently been tracked in functional connectivity (FC) calculated from resting-state magnetic resonance imaging (R-fMRI), when a person is conscious but not carrying out directed task during scanning. Diverse dynamical FC states (dFC) are believed to represent different internal of the brain, terms brain-regional interactions. In this paper, we propose novel protocol, signed community clustering with optimized modularity by two-step procedures, track whole brain (dWFC)...
Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources most serotonergic neurons project throughout brain. Incorporating measurements activity within raphe into analysis connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers involved in pathogenesis MDD. Here, we analyzed resting-state functional magnetic resonance imaging (RS-fMRI) dataset...
Age-related changes in the brain are associated with a decline functional flexibility. Intrinsic flexibility is evident brain's dynamic ability to switch between alternative spatiotemporal states during resting state. However, relationship connectivity states, psychological functions state, and normal aging remain poorly understood. In this study, we analyzed resting-state magnetic resonance imaging (rsfMRI) data from Human Connectome Project (HCP; N = 812) UK Biobank (UKB; 6,716). Using...
The relationship between tumor mass and peritumoral structures including edema is important for planning surgical trajectory crucial diagnosis, excision, post-surgical outcome. recent development of diffusion tensor MRI has shown its feasibility in grading tumor, monitoring therapeutic effects, post-surgery To visualize the structure, a 3D virtual reality environment was developed. Neural tractography anatomy were integrated this interaction VR system. Using controller, suitable can be...
The frequently discovered incidental findings (IFs) from imaging observations are increasing. IFs show the potential clues of structural abnormalities underlying cognitive decline in elders. Detecting brain and their relationship with behavioral functions helps provide information for clinical strategies.Five hundred seventy-nine participants were recruited Shanghai Changfeng Study. All performed demographic, biochemical, gait speed assessment underwent high-resolution multimodal magnetic...
Abstract White matter hyperintensity (WMH) is associated with vascular hemodynamic alterations and reflects white injury. To date, the sex difference of tract‐specific WMH relationship between high blood pressure (BP) remain unclear. We recruited 515 subjects from Shanghai Changfeng study (range 53–89 years, mean age 67.33 years). Systolic diastolic (SBP DBP) were collected used to calculate pulse (PP). Magnetic resonance T1 T2 FLAIR images acquired measure index. The ANCOVA test was...
The design of a Chebyshev functional link artificial neural networks (CFLANN) based channel equalizer in digital communication systems is discussed this paper. has been successfully applied to which 16-QAM modulated signals are transmitted. To improve performance, decision feedback mechanism used the (DF-CFLANN). But computational complexity DF-CFLANN about 60% higher than CFLANN. In paper, we propose reduced network (RDF-CFLANN) not only simple structure, but also exhibits better...
Subjective cognitive decline (SCD) as an indicator of preclinical Alzheimer’s disease (AD) may precede mild impairment (MCI) over several decades. Self-reported a typical clinical manifestation is critical in AD. Metacognition represents person’s ability to accurately assess cognition. Our study aimed examine (1) the alternations metamemory cohort across continuum, (2) association between and cognition, (3) relationship cortical thickness four regions interest (ROI) with scores. Six hundred...