A5022641514- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Mobile Health and mHealth Applications
- Neuroscience of respiration and sleep
- Healthcare professionals’ stress and burnout
- Genetics, Aging, and Longevity in Model Organisms
- Renal and related cancers
- CRISPR and Genetic Engineering
- Dysphagia Assessment and Management
- Theatre and Performance Studies
- Family and Patient Care in Intensive Care Units
- Cultural Industries and Urban Development
- Artistic and Creative Research
- Pluripotent Stem Cells Research
- Circadian rhythm and melatonin
- Diversity and Career in Medicine
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Behavioral Health and Interventions
- Muscle activation and electromyography studies
- Irish and British Studies
- Ovarian cancer diagnosis and treatment
- Neonatal and fetal brain pathology
- Innovations in Medical Education
- Quality and Safety in Healthcare
- Sports Performance and Training
Massachusetts General Hospital
2024
Harvard University
2014-2024
Medical University of South Carolina
2016-2024
Children's Hospital of Richmond at VCU
2024
National Cancer Institute
2020-2024
University of Cincinnati
2024
University of Colorado System
2024
University of Colorado Boulder
2024
University of South Carolina
2023
University of Minnesota
1988-2022
The significance of the phenotypic plasticity afforded by epithelial-mesenchymal transition (EMT) for cancer progression and drug resistance remains to be fully elucidated in clinic. We evaluated characteristics across a range tumor histologies using validated, high-resolution digital microscopic immunofluorescence assay (IFA) that incorporates β-catenin detection cellular morphology delineate carcinoma cells from stromal fibroblasts quantitates individual colocalized expression epithelial...
Biogenic amines modulate key behaviors in both vertebrates and invertebrates. In Caenorhabditis elegans, tyramine (TA) octopamine (OA) inhibit aversive responses to 100%, but not dilute (30%) octanol. TA OA also abolish food- serotonin-dependent increases octanol wild-type tyra-3(ok325) f14d12.6(ok371) null animals, respectively, suggesting that modulated are mediated by separate, previously uncharacterized, G-protein-coupled receptors. high-affinity ligands for TYRA-3 F14D12.6, based on...
Serotonin modulates behavioral plasticity in both vertebrates and invertebrates Caenorhabditis elegans regulates key behaviors, including locomotion, aversive learning olfaction through at least four different 5-HT receptors. In the present study, we examined serotonergic stimulation of responses to dilute octanol animals containing null alleles these Both ser-1 mod-1 failed increase sensitivity on food/5-HT, contrast wild-type, ser-4 or ser-7 animals. was restored by expression MOD-1 SER-1...
The mechanisms controlling cell fate determination and reprogramming are fundamental for development. A profound reprogramming, allowing the production of pluripotent cells in early embryos, takes place during oocyte-to-embryo transition. To understand how oocyte potential is controlled, we sought Caenorhabditis elegans mutants which embryonic transcription initiated precociously germ cells. This screen identified LIN-41, a TRIM-NHL protein component somatic heterochronic pathway, as...
Abstract The intracellular effects and overall efficacies of anticancer therapies can vary significantly by tumor type. To identify patterns drug-induced gene modulation that occur in different cancer cell types, we measured gene-expression changes across the NCI-60 line panel after exposure to 15 agents. results were integrated into a combined database set interactive analysis tools, designated NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), allows exploration molecular pathway,...
The orbitofrontal cortex (OFC) is implicated in depression. hypothesis investigated was whether the OFC sensitivity to reward and nonreward related severity of depressive symptoms. Activations monetary incentive delay task were measured IMAGEN cohort at ages 14 years (n = 1877) 19 1140) with a longitudinal design. Clinically relevant subgroups compared (high-severity group: n 116; low-severity 206) 14. medial exhibited graded activation increases reward, lateral had nonreward. In this...
Abstract Purpose: The Wee1 kinase inhibitor adavosertib abrogates cell-cycle arrest, leading to cell death. Prior testing of twice-daily in patients with advanced solid tumors determined the recommended phase II dose (RPh2D). Here, we report results for once-daily adavosertib. Patients and Methods: A 3 + dose-escalation design was used, given once daily on days 1 5 8 12 21-day cycles. Molecular biomarkers activity, including tyrosine 15–phosphorylated Cdk1/2 (pY15-Cdk), were assessed paired...
Abstract On 4 July 1986, dye was injected at a point slightly above the equilibrium line on Storglaciären, small valley glacier in northern Sweden. Just below line, bed is over-deepened. The re-appeared stream terminus over next 35 d. This normally carries relatively little sediment, constrast to situation another nearby that also emerges from glacier. suggests traveled englacial rather than subglacial conduits. Tracer tests utilizing salt bore holes overdeepening support this...
Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia remain the leading causes of preterm infant morbidity, mortality, lifelong disability. Research to improve outcomes requires translational large animal models for RDS. Preterm pigs delivered by caesarian section at gestation days (GD) 98, 100, 102, 104 were provided 24 h neonatal intensive care, monitoring (pulse oximetry, blood gases, serum biomarkers, radiography), nutritional support, with or without intubation mechanical...
Abstract Fluoxetine is one of the most commonly prescribed medications for many behavioral and neurological disorders. acts primarily as an inhibitor serotonin reuptake transporter (SERT) to block removal from synaptic cleft, thereby enhancing signals. While effects fluoxetine on behavior are firmly established, debate ongoing whether inhibition a sufficient explanation its therapeutic action. Here, we provide evidence two additional aspects action through genetic analyses in Caenorhabditis...
Background Asthma is a common chronic pediatric disease that can negatively impact children and families. Self-management strategies are challenging to adopt but critical for achieving positive outcomes. Mobile health technology may facilitate self-management of asthma, especially as adolescents mature assume responsibility their disease. Objective This study aimed explore the perceptions youths with high-risk asthma caregivers on use smartphone app, Smartphone Management System, in...
Introduction: The comprehensive educational component of pulmonary rehabilitation (PR) is an important chronic obstructive disease (COPD) self-management. However, depending on circumstances PR may not be convenient or appropriate for individual patient and thus these patients do access the PR. Background: COPD, due to its symptoms imposes a significant burden affected person in terms quality life effects daily activities [1]. Self-management term applied programmes aimed at teaching skills...
Abstract Background Current treatments for Tourette syndrome (TS) and persistent tic disorder (PTD) are often insufficiently effective, inaccessible, frequently associated with adverse events. Thus, we must continue to develop test accessible, safe treatment options. Objective We aimed conduct a pilot randomized controlled trial (RCT) comparing novel, videoconference‐delivered group mindfulness‐based intervention tics (MBIT) psychoeducation, relaxation, supportive therapy (PRST) adults TS or...
Poor oral health is associated with adverse outcomes in critical care settings. Although provision of a fundamental aspect nursing practice, both formal training and practice among staff remain unclear.Cardiothoracic intensive unit nurses were recruited to complete 16-item survey regarding training, confidence, methods, prioritization, barriers care.A total 108 participated (70% response rate). Formal was reported by 38%, most frequently as less than 1 hour (53%) duration. Of the...
Abstract Purpose Following promising responses to the DNA methyltransferase (DNMT) inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) combined with tetrahydrouridine (THU) in phase 1 testing, we initiated a non-randomized 2 study assess response this combination patients advanced solid tumor types for which suppressor gene methylation is potentially prognostic. To obtain pharmacodynamic evidence DNMT inhibition by FdCyd, developed novel method detecting expression of protein p16/INK4A circulating...
<h3>Background</h3> Treatment for relapsed/refractory [r/r] AML and high risk MDS is dismal NK cell infusions (with IL-2 or IL-15) after lymphodepleting chemotherapy can result in 30–40% remission. However, cells lack antigen specificity require cytokine expansion. We have developed a novel tri-specific molecule,<sup>1</sup> termed GTB-3550 TriKE, comprised of IL-15 surrounded by two single chain variable fragments (scFvs), one against CD16 on CD33 blasts. <h3>Methods</h3> Supported...
Dyspnea is an unpredictable and distressing symptom of chronic obstructive pulmonary disease (COPD).Dyspnea challenging to measure due the heterogeneity COPD recall bias associated with retrospective reports.Ecological Momentary Assessment (EMA) a technique used collect symptoms in real-time within natural environment, useful for monitoring trends risks exacerbation COPD.EMA can be integrated into mobile health (mHealth) platforms repeated data collection alongside physiological measures...
Successful leaders influence the group they represent. Effective surgical care is tied to its leadership climate. However, most providers are not attuned their individual strengths which if known could leverage them within teams. This study identifies types a department of surgery may be used better understand and cultivate strengths.
Through the use of conspecific models and vocalizations, populations conservation concern can be established in locations where limiting factors may controlled or mitigated, assuming managers both identify create high-quality locations. From 2003 to 2008, attraction was used establish state-endangered Forster's Tern (Sterna forsteri) northeastern Illinois, USA. In 2009 2010, similar techniques were with federally-threatened Least Tern, (Stemula antillarum) near confluence Missouri...
Youth with multi-morbidity (one or more chronic diseases) are at increased risk of further morbidity and early mortality as they enter their adult years. Recent increases in both asthma obesity among youth have led to high health care utilization, related complications, expanded risks subsequent cardiovascular disease burden. Common symptoms seen include fatigue, pain, depression, anxiety. These can result decreased physical activity, social isolation, poor quality life, which also may...
Abstract Dyspnea and fear of suffocation are burdensome to patients with respiratory disease. Inspiratory resistive loads offer an experimental stimulus quantify the discriminative domain perception. Resistive ( R ) load magnitude estimation ME subjective ratings were measured over sustained multiple breaths in healthy subjects. There was no significant group difference between for Breath 1 20 small loads, but a gender large loads. Subjective responses fear, suffocation, displeasure, chest...