A5004918887- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Chronic Kidney Disease and Diabetes
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Sodium Intake and Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Natural Compounds in Disease Treatment
- Dialysis and Renal Disease Management
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Macrophage Migration Inhibitory Factor
- Vitamin D Research Studies
- Connexins and lens biology
- Renal and Vascular Pathologies
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Kidney Stones and Urolithiasis Treatments
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
Sun Yat-sen University
2013-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2014-2024
Key Laboratory of Guangdong Province
2020
British Heart Foundation
2019
King's College London
2019
Imperial College London
2016
Abstract Background (Pro)renin receptor (PRR) is highly expressed in renal tubules, which involved physiological and pathological processes. However, the role of PRR, tubular epithelial cells, diabetic kidney disease (DKD) remain largely unknown. Methods In this study, biopsies, urine samples, public RNA-seq data from DKD patients were used to assess PRR expression cell pyroptosis cells. The regulation by was investigated situ injection adeno-associated virus9 (AAV9)-shRNA into db/db mice,...
Background/Aims: Previously we have shown that activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) attenuated hyperglycemia-induced damage in podocytes, but molecular mechanism remains unknown. Methods: Tert-butylhydroquinone (t-BHQ) and small interfering RNAs (siRNAs) were used to regulate Nrf2 expression, while nicotinamide siRNAs sirtuin 1 (Sirt1) activity respectively. Mitochondrial superoxide, membrane potential ATP levels measured...
Previous studies suggested that inflammation was involved in chronic heart failure (CHF), but their sample sizes were small.To summarise the clinical cytokine data systematically and emphasise importance of proinflammatory cytokines pathogenesis CHF, we conducted a meta-analysis relevant literatures.Articles about CHF searched Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure Wanfang Database. The pooled effects measured by weighted mean difference (MD) 95% CI,...
In this study, we hypothesized that the combination of hepatocyte growth factor (HGF) and insulin-like factor-1 (IGF-1) alters expression connexin 43 (Cx43) results in a reduced frequency induced ventricular arrhythmia rats after myocardial infarction (MI) explored preliminary mechanisms involved.Cardiomyocytes were cultured vitro medium with PBS, HGF, IGF-1, GFs (HGF + IGF-1), HGF p38 inhibitor, ERK IGF-1 inhibitor or inhibitor. The Cx43 was tested by real-time PCR Western blotting 48...
Damage to the vasculature is primary mechanism driving chronic diabetic microvascular complications such as nephropathy, which manifests albuminuria. Therefore, treatments that protect have significant therapeutic potential. Soluble neurite outgrowth inhibitor-B (sNogo-B) a circulating N-terminus isoform of full-length Nogo-B, plays key role in vascular remodeling following injury. However, there currently no information on sNogo-B context nephropathy. We demonstrate overexpression...
To determine the prevalence of masked morning hypertension and investigate its role in target organ damage nondialysis patients with chronic kidney disease.A total 1841 disease admitted to our hospital were recruited. According measurements clinic blood pressure ambulatory pressure, they divided into four groups: normotension, white-coat hypertension, sustained hypertension. Multivariate logistic regression analyses used evaluate association between cardiovascular renal parameters.Overall,...
The efficacy of gliquidone for the treatment diabetic nephropathy was investigated by implanting micro-osmotic pumps containing into abdominal cavities Goto-Kakizaki (GK) rats with nephropathy. Blood glucose, 24 h urinary protein, and albumin levels were measured weekly. After 4 weeks therapy, pathological changes in glomerular basement membrane (GBM) examined using an electron microscope. Real-time PCR, western blotting, immunohistochemistry employed to detect expression receptors advanced...
Background: Acute myeloid leukemia (AML) is a common hematological malignancy treated with regimens containing anthracycline, an agent cardiotoxicity. However, the cardiac-specific mortality in AML patients receiving chemotherapy remains unknown. Methods: In this population-based study, diagnosed between 1973 and 2015 were identified Surveillance, Epidemiology, End Results database. Cumulative by cause of death was calculated. To quantify excessive compared general population, standardized...
Abstract Both morning hypertension (MH) and nocturnal (NH) are associated with severe target organ damage in patients chronic kidney disease (CKD). However, the isolated or combined effects of MH NH on less well‐defined. A cross‐sectional study was conducted among 2386 non‐dialysis CKD ambulatory blood pressure monitoring. The authors categorized into four groups based presence absence NH. Multivariate logistic analyses were used to evaluate correlation between subtypes damage, including...
Abstract Background Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet little known about the association of various types BP measurements target organ damage (TOD) primary glomerular disease. The goal this study was to investigate whether ambulatory better associated TOD than clinic Methods 1178 were recruited cross-sectional study. assessed...
Biomarkers of oxidative stress (OS) have been poorly explored in fungal peritonitis (FP). Potassium is a regulator pro-oxidants and antioxidants. Albumin vitamin B12 (B12) are vital antioxidant agents the circulatory system. This study aimed to investigate antioxidative role serum potassium, albumin FP.Serum levels were retrospectively analyzed 21 patients with confirmed diagnosis FP, 105 bacterial (BP) 210 receiving peritoneal dialysis without peritonitis.Serum lower FP than BP patients....
Objective: To assess the efficacy of isoproterenol (ISO) in establishment chronic heart failure (CHF) and cardiac remodeling model rats.Methods: Twelve Wistar rats were randomly divided into two groups: control group (n=3) (n=9).Rats hypodermic injected with ISO 5mg/kg/d for 10 days.Ultrasonic cardiogram, HE staining， immunohistochemistry collagen Ⅰ Masson staining performed to evaluate function myocardial fibrosis.Besides, ventricular mass/body mass ratio, volume fraction (CVF),...
Background:The effect of triptolide (TPL) on cardiac fibroblasts (CFbs) and fibrosis remain unknown till now.This study was conducted to explore the effects TPL proliferation apoptosis angiotensin II (Ang II)-induced CFbs. Materials Methods:Ang used promote CFbs.Two dosages (10ng/ml 100ng/ml) were chosen.MTT assay detect cell survival rate in vitro.Flow cytometer performed analyze CFbs.Hydroxyproline concentration detected with hydroxyproline kit.Quantitative real-time PCR expression TGF-β1...
The aim of this study was to investigate associations between age-dependent variations in isolated systolic/diastolic hypertension (ISH/IDH) with target organ damage chronic kidney disease (CKD). A cross-sectional conducted among 2,459 CKD patients ambulatory blood pressure monitoring. Blood categorized into four groups: normotension, ISH, IDH, and systolic-diastolic hypertension. outcome measurements were left ventricular mass index (LVMI), estimated glomerular filtration rate(eGFR),...
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Vorapaxar, a protease-activated receptor-1 (PAR-1) antagonist, novel antiplatelet agent that may provide us new way in antithrombotic therapy. Several studies had been conducted to evaluate efficacy vorapaxar treatment CAD, but results were inconsistent. Here meta-analysis was made assess safety reducing adverse cardiac events patients with CAD.A comprehensive literature search conducted. The primary...
Background: Recent studies have shown that the baseline values of absolute aortic root diameter (ARD) and indexed are associated with all-cause mortality cardiovascular events in general population, even absence aneurysmal disease. However, there is limited available data on association between ARD prognosis end-stage renal disease (ESRD) patients receiving maintenance hemodialysis (MHD). Accordingly, purpose this study to investigate predictive value for specific population.Methods: was...
Multiple target-organ damages (TODs) in the same patient are common and further increase risk of cardiovascular disease. However, relationship between ambulatory central systolic blood pressure (SBP) multiple TODs has yet to be explored.
Sodium homeostasis is intimately associated with blood pressure (BP) rhythm, and potassium excretion closely sodium in the general population. However, association between circadian pattern nocturnal BP patients chronic kidney disease (CKD) not elucidated.