A5086163460- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Asthma and respiratory diseases
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Complement system in diseases
- Ocular Disorders and Treatments
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Signaling Pathways in Disease
- Craniofacial Disorders and Treatments
- Urinary and Genital Oncology Studies
- Bone and Dental Protein Studies
- RNA Research and Splicing
Jinan University
2025
Guangxi Medical University
2021-2024
Anhui University
2024
Tongji University
2014-2024
BGI Group (China)
2013-2024
Zhongnan Hospital of Wuhan University
2020-2024
Wuhan University
2020-2024
Hebei General Hospital
2024
Simcere Pharmaceutical (China)
2021-2023
BGI Genomics
2023
Abstract Legumain is required for maintenance of normal kidney homeostasis. However, its role in acute injury (AKI) still unclear. Here, we induced AKI by bilateral ischemia-reperfusion (IRI) renal arteries or folic acid lgmn WT and KO mice. We assessed serum creatinine, blood urea nitrogen, histological indexes tubular injury, expression KIM-1 NGAL. Inflammatory infiltration was evaluated immunohistological staining CD3 F4/80, TNF-α, CCL-2, IL-33, IL-1α. Ferroptosis Acsl4, Cox-2, reactive...
In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, TILs do not routinely express IL10, as autocrine complement C3 inhibits production through receptors C3aR C5aR. from C3-deficient mice, however, exhibit enhanced effector function. mice are resistant tumor development in a T-cell- IL10-dependent manner; human expanded with IL2 plus increase the killing of primary tumors vitro compared...
Lipoteichoic acid (LTA) induces neuroinflammatory molecules, contributing to the pathogenesis of neurodegenerative diseases. Therefore, suppression molecules could be developed as a therapeutic method. Although previous data supports an immune-modulating effect curcumin, underlying signaling pathways are largely unidentified. Here, we investigated curcumin's anti-neuroinflammatory properties in LTA-stimulated BV-2 microglial cells. Inflammatory cytokine tumor necrosis factor-α [TNF-α,...
Personalized theranostics of cancer is increasingly desired, and can be realized by virtue multifunctional nanomaterials with possible high performances. Gold nanoparticles (GNPs) are a type especially promising candidate for theranostics, because their synthesis modification facile, structures physicochemical properties flexibly controlled, they also biocompatible. Especially, the localized surface plasmon resonance multivalent coordination effects on endow them NIR light-triggered...
Fig pollinating wasps form obligate symbioses with their fig hosts. This mutualism arose approximately 75 million years ago. Unlike many other intimate symbioses, which involve vertical transmission of symbionts to host offspring, female fly great distances transfer horizontally between In contrast, male are wingless and cannot disperse. Symbionts that keep contact hosts often show genome reduction, but it is not clear if the wide dispersal will counteract this general tendency. We sequenced...
Lung cancer is one of the most malignant cancers worldwide, and lung adenocarcinoma (LUAD) common histologic subtype. Thousands biomarkers related to survival prognosis patients with this type have been investigated through database mining; however, prediction effect a single gene biomarker not satisfactorily specific or sensitive. Thus, present study aimed develop novel signature prognostic values for LUAD. Using data-mining method, we performed expression profiling 1145 mRNAs in large...
In this study, topotecan-loaded mesoporous silica nanoparticles were prepared and surface conjugated with folic acid (FTMN) to enhance the therapeutic efficacy of topotecan for treatment retinoblastoma (RB) cancers. The particles nano-sized exhibited a sustained release drug in physiological conditions. acid-conjugated nanoformulations remarkable uptake RB cells compared that non-targeted nanoparticles. These results clearly indicate receptor-mediated endocytosis is mechanism cellular...
This study was conducted to establish a stable hypobaric hypoxia brain injury model. SD rats were randomly separated into control and model groups, placed outside or inside of chamber, respectively. Subsequent 24 h anoxic exposure, plasma superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), oxidized (GSSG) lactate dehydrogenase (LDH) measured using commercial biochemical kits. Hematoxylin‑eosin (H&E), Nissl's terminal deoxynucleotidyl transferase dUTP nick end labeling...
Abstract Background Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant constituents praeruptorin (A–E), are active in dried roots of P. praeruptorum. Previous transcriptomic and metabolomic studies have attempted to elucidate distribution biosynthetic network these medicinal-valuable compounds. However, lack high-quality reference genome impedes an in-depth understanding genetic traits thus development...
Turbine compressors are highly efficient power widely used in fields such as chemical engineering and refrigeration. However, there is vibration during compressor operation, the noise amplified through transmission path of structure itself, which has adverse effects on production environment health operators. Therefore, this article analyzes mechanism generation propagation turbine compressors, constructs a model. Based above two models, by collecting separating sound, at source can be...
The B7 gene family has crucial roles in the regulation of adaptive cellular immunity. In cancer, deregulation co-inhibitory molecules is associated with reduced antitumor immunity and cancer immune evasion. FDA approval immunotherapy antibodies against cytotoxic T lymphocyte-associated protein 4 (CTLA-4) programmed cell death-1 (PD-1)—both ligands family—demonstrate impact these checkpoint regulators cancer. Using data from cBioPortal, we performed comprehensive molecular profiling 10...
Background: Immunotherapy has brought substantial benefit for patients with advanced non-small cell lung cancer (NSCLC); however, resistance may occur, of which oligoprogression is most common. There are no standard strategies to overcome acquired resistance, thus exploring potential effective approaches critical. Our study evaluated the clinical outcome combing stereotactic body radiotherapy (SBRT) checkpoint inhibitors (CPIs) in oligoprogressive NSCLC. Methods: We retrospectively reviewed...
Most grouper species are functional protogynous hermaphrodites, but the genetic basis and molecular mechanisms underlying regulation of this unique reproductive strategy remain enigmatic. In study, we report a high-quality chromosome-level genome assembly representative orange-spotted (Epinephelus coioides). No duplication or deletion sex differentiation-related genes was found in genome, suggesting that development may be related to changes regulatory sequences environmental factors....
Angiogenesis is crucially involved in many physiological and pathological processes including tumor growth, but the molecular mechanisms regulating angiogenesis are incompletely understood. In this study, we investigated functions mechanism of histone deacetylase 10 (HDAC10), a member HDAC II family, regulation angiogenesis. HDAC10 overexpression human umbilical vein endothelial cells (HUVECs) promoted tube formation, whereas depletion from HUVECs inhibited formation vitro vivo....
Due to drug-induced potential congestive heart failure and irreversible dilated cardiomyopathies, preclinical evaluation of cardiac dysfunction is important assess the safety traditional or novel treatments. The embryos Nelumbo nucifera Gaertner seeds are a homology Chinese medicine food. In this study, we applied real time cellular analysis (RTCA) Cardio system, which can real-time monitor contractility cardiomyocytes (CMs), evaluate drug in rat neonatal CMs human induced pluripotent stem...
This article is dedicated to finding important genes related the prognosis of lung adenocarcinoma (LUAD), looking for a new gene that may affect tumor radiosensitivity, and conducting basic experiments verify relationship between this radiosensitivity LUAD.The expression profiles GSE32863, GSE33532, GSE43458 were obtained from NCBI-GEO. GEO2R Venn diagram used identify upregulated genes. STRING Cytoscape applied develop protein-protein interaction network (PPI) analyze modules. The Database...
In clinical practice, an unexplained discordance between percentage haemoglobin A1c (HbA1c) and the progression of diabetes its complication is observed. HbA1c determined by blood glucose level red cell (RBC) lifespan. Whether RBC lifespan changes in diabetic patients remains undefined because lack a convenient accurate measurement method. present study, we aim to observe type 2 with poor control endogenous carbon monoxide (CO) using rapid simplified CO breath test machine. The lifespan,...
Abstract Histone methylation is thought to control the regulation of genetic program and dysregulation it has been found be closely associated with cancer. JMJD3 identified as an H3K27 demethylase its role in cancer development context specific. The gastric (GC) not examined. In this study, expression was determined. prognostic significance association clinical parameters were evaluated. mechanism targets analyzed. effect mutation determined by functional study. Results showed that...