A5024146445- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Complement system in diseases
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Radiation Dose and Imaging
- Advanced Proteomics Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Trauma Management and Diagnosis
- Neuroendocrine Tumor Research Advances
- Pneumothorax, Barotrauma, Emphysema
- Occupational and environmental lung diseases
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
Duke University
2009-2025
Duke Medical Center
2015-2024
Duke University Hospital
2013-2023
Duke University Health System
2008-2021
National Cancer Institute
2014
Marshfield Clinic
2014
Washington University in St. Louis
2014
University of North Carolina at Chapel Hill
2012
International Association for the Study of Lung Cancer
2008
Society of Thoracic Surgeons
2005
<h3>Importance</h3> Screening for lung cancer has the potential to reduce mortality, but in addition detecting aggressive tumors, screening will also detect indolent tumors that otherwise may not cause clinical symptoms. These overdiagnosis cases represent an important harm of because they incur additional cost, anxiety, and morbidity associated with treatment. <h3>Objective</h3> To estimate National Lung Trial (NLST). <h3>Design, Setting, Participants</h3> We used data from NLST, a...
PURPOSE: To test the hypothesis that absence of statistically significant lung nodule enhancement (≤15 HU) at computed tomography (CT) is strongly predictive benignity. MATERIALS AND METHODS: Five hundred fifty nodules were studied. Of these, 356 met all entrance criteria and had a diagnosis. On nonenhanced, thin-section CT scans, solid, 5–40 mm in diameter, relatively spherical, homogeneous, without calcification or fat. All patients examined with 3-mm-collimation before after intravenous...
Solitary pulmonary nodules (SPNs) are commonly identified by chest radiographs and computed tomography (CT). Biopsies often performed to evaluate the further. An accurate, noninvasive diagnostic test could avoid morbidity costs of invasive tissue sampling. We evaluated ability fluorine-18 deoxyglucose positron emission (FDG-PET) discriminate between benign malignant in a prospective, multicenter trial.Eighty-nine patients who had newly indeterminate SPNs on CT were with FDG-PET. PET data...
The authors assessed the role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in differentiation benign from malignant focal pulmonary abnormalities seen on chest radiographs. Fifty-one patients underwent FDG PET scanning. Focal at radiography included solitary nodules (n = 38), masses 5), and poorly marginated infiltrates or opacities 8). Proof diagnosis was obtained by means transbronchial biopsy 21), open lung 14), percutaneous needle cytologic evaluation...
Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence.The authors reviewed all in our tissue databank from 1996 2001 identified 64 consecutive pathologic I non-small cell (NSCLC) who had surgical resection at least 2.5 years disease-free follow-up...
PURPOSE: To compare the accuracies of whole-body 2-[fluorine 18]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) and conventional imaging (thoracic computed [CT], bone scintigraphy, brain CT or magnetic resonance [MR] imaging) in staging bronchogenic carcinoma. MATERIALS AND METHODS: Within 20 months, 100 patients with newly diagnosed carcinoma underwent FDG PET chest CT. Ninety these radionuclide 70 MR imaging. For each patient, all examinations were completed within 1...
The purpose of this study was to determine the spectrum positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) findings in patients who have primary pulmonary carcinoid tumors.On FDG PET imaging, tumors usually lower uptake than expected for malignant tumors. Biopsy or close radiologic follow-up is therefore recommended solitary nodules that are clinically suspected being and do not show increased metabolic activity on images.
Abstract BACKGROUND A fundamental property of malignant tumors is increased glucose metabolism, which can be estimated by imaging the analog fluorodeoxyglucose (FDG). The aim this study was to determine whether FDG uptake in lung carcinoma, as measured on positron emission tomography (PET) patients with newly diagnosed bronchogenic has prognostic significance. METHODS retrospective review all a new diagnosis nonsmall cell carcinoma and FDG-PET performed. Stage at presentation, type, tumor...
The purpose of this study was to assess the usefulness positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) when differentiating benign from metastatic adrenal masses in patients bronchogenic carcinoma.For our prospective study, any patient presenting institution pathologically proven carcinoma and an mass eligible. Thirty-three (mean size, 3 cm; range, 1-9 cm) 27 were revealed by CT. PET performed all interpreted as positive FDG uptake greater than background activity or...
Currently, a blood test for lung cancer does not exist. Serum biomarkers that could aid clinicians in making case management decisions would be enormously valuable. We used two proteomic platforms and literature search to select candidate serum markers the diagnosis of cancer.We initially assayed six proteins, four discovered by proteomics previously known associated, on training set sera from 100 patients (50 with new 50 age- sex-matched controls). Classification Regression Tree (CART)...
Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability.E F Patz, Jr, K Shaffer, D R Piwnica-Worms, M Jochelson, Sarin, J Sugarbaker PugatchAudio Available | Share
The purpose of this study was to characterize the radiologic manifestations pulmonary mucormycosis with clinical and pathologic correlation.Clinical records, pathology reports, chest radiographs, CT scans 32 cases pathologically proven were retrospectively reviewed.The group included 20 males 12 females a mean age 47 years old. Clinical data available for 29 patients. Signs symptoms fever (n = 23), cough 21), bloody sputum 9), dyspnea 7), pain 6). Four patients asymptomatic. Most either...
To assess positron emission tomography (PET) with 2-[fluorine-18]-2-deoxy-D-glucose (FDG) in the differentiation of recurrent bronchogenic carcinoma from fibrosis after therapy.Any patient treated for who had a residual chest radiographic abnormality was eligible. Forty-three patients (mean age, 63.5 years) participated. Chest radiographs and thoracic computed tomographic scans helped localize prior to PET. Semiquantitative analysis performed on FDG PET images calculated standardized uptake...
In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, TILs do not routinely express IL10, as autocrine complement C3 inhibits production through receptors C3aR C5aR. from C3-deficient mice, however, exhibit enhanced effector function. mice are resistant tumor development in a T-cell- IL10-dependent manner; human expanded with IL2 plus increase the killing of primary tumors vitro compared...