A5060708763- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Global Cancer Incidence and Screening
- Medical Imaging Techniques and Applications
- Transplantation: Methods and Outcomes
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Airway Management and Intubation Techniques
- Radiation Dose and Imaging
- Foreign Body Medical Cases
- Cancer survivorship and care
- Salivary Gland Tumors Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Vascular Anomalies and Treatments
- Eosinophilic Esophagitis
- Neuroendocrine Tumor Research Advances
- Sarcoidosis and Beryllium Toxicity Research
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
Mayo Clinic
2014-2024
Mayo Clinic in Arizona
2014-2023
Mayo Clinic in Florida
2005-2023
Pulmonary and Critical Care Associates
2001-2023
WinnMed
1996-2023
University Medical Center Groningen
2019
University of Groningen
2019
American College of Chest Physicians
2015
American Thoracic Society
2015
Nanjing University
2010-2011
Studies suggest that screening with spiral computed tomography can detect lung cancers at a smaller size and earlier stage than chest radiography can. To evaluate low-radiation-dose sputum cytology in for cancer, we enrolled 1,520 individuals aged 50 yr or older who had smoked 20 pack-years more prospective cohort study. One year after baseline scanning, 2,244 uncalcified nodules were identified 1,000 participants (66%). Twenty-five cases of cancer diagnosed (22 prevalence, 3 incidence)....
To evaluate a large cohort of patients at high risk for lung cancer by using screening with low-dose spiral computed tomography (CT) the chest.A prospective study was performed 1,520 individuals aged 50 years or older who had smoked 20 pack-years more. Participants underwent three annual CT examinations chest and upper abdomen. Characteristics pulmonary nodules additional findings were tabulated analyzed.Two after baseline scanning, 2,832 uncalcified identified in 1,049 participants (69%)....
PURPOSE: To test the hypothesis that absence of statistically significant lung nodule enhancement (≤15 HU) at computed tomography (CT) is strongly predictive benignity. MATERIALS AND METHODS: Five hundred fifty nodules were studied. Of these, 356 met all entrance criteria and had a diagnosis. On nonenhanced, thin-section CT scans, solid, 5–40 mm in diameter, relatively spherical, homogeneous, without calcification or fat. All patients examined with 3-mm-collimation before after intravenous...
To report results of a 5-year prospective low-dose helical chest computed tomographic (CT) study cohort at high risk for lung cancer.After informed written consent was obtained, 1520 individuals were enrolled. Protocol approved by institutional review board and National Cancer Institute compliant with Health Insurance Portability Accountability Act, or HIPAA. Participants aged 50 years older had smoked more than 20 pack-years. underwent five annual (one initial four subsequent) CT...
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the circulation; however, it is currently unknown whether elicits effective immune responses respiratory tract, particularly against variants of concern (VOCs), including Omicron. We compared S-specific total neutralizing antibody responses, B T cell immunity, bronchoalveolar lavage fluid (BAL) blood COVID-19-vaccinated individuals hospitalized patients. Vaccinated had significantly lower levels D614G, Delta...
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The NCCN Guidelines for Lung Cancer Screening recommend criteria selecting individuals screening and provide recommendations evaluation follow-up of lung nodules found during initial subsequent screening. These Insights focus on recent updates to the Screening.
To retrospectively evaluate the computed tomography (CT)-determined size, morphology, location, morphologic change, and growth rate of incidence prevalence lung cancers detected in high-risk individuals who underwent annual chest CT screening for 5 years to histologic features stages these cancers.The study was institutional review board approved HIPAA compliant. Informed consent waived. scans 61 (24 men, 37 women; age range, 53-79 years; mean, 65 years) were reviewed cancer location....
To determine if lung nodule enhancement measured with computed tomography (CT) is directly related to the likelihood of malignancy and vascularity.Radiologically indeterminate 7-30-mm pulmonary nodules were studied in 107 patients malignant neoplasms (n = 52), granulomas 51), benign 4). Attenuation was recorded from serial thin-section CT scans before after injection contrast material. Twenty-four histologic specimens graded immunoperoxidase vascular staining antibody factor VIII-associated...
PURPOSE: To describe the computed tomographic (CT) findings in patients with nonspecific interstitial pneumonia (NSIP) and to compare these CT of other chronic infiltrative lung diseases. MATERIALS AND METHODS: Findings 50 biopsy–proved NSIP a scan were reviewed by two thoracic radiologists consensus. After described, observers judged whether compatible previously published descriptions or would support diagnosis different disease. RESULTS: Eleven (22%) had that previous NSIP. Sixteen (32%)...
Abstract BACKGROUND. Primary salivary‐type lung cancers are rare tumors that include adenoid cystic carcinoma (ACC) and mucoepidermoid (MEC). The clinicopathologic profiles, symptoms on presentation, long‐term outcomes of patients with ACC MEC as an overall group have not been defined recently. METHODS. In this study, the authors analyzed clinical outcome data from 62 who presented a diagnosis primary cancer at Mayo Clinic (Rochester, Minn) 1972 to 2002. RESULTS. median age for was 40 years...
Genetic susceptibility in lung cancer risk has long been recognized but remains ill defined, as does the role of tobacco smoke exposure and chronic obstructive pulmonary disease (COPD).Using a dual case-control design, we tested whether alpha(1)-antitrypsin deficiency (alpha(1)ATD) carriers are predisposed to higher cancer, adjusting for effects COPD. A total 1856 patients with incident were included study; 1585 community residents served controls. second control group was composed 902 full...
Fibrosing mediastinitis (FM) is a rare disorder characterized by the invasive proliferation of fibrous tissue within mediastinum. FM frequently results in compression vital mediastinal structures and has been associated with substantial morbidity mortality. Its pathogenesis remains unknown. However, North America most cases are thought to represent an immune-mediated hypersensitivity response Histoplasma capsulatum infection. To characterize clinical disease spectrum, natural progression,...
Lung nodules are a diagnostic challenge, with an estimated yearly incidence of 1.6 million in the United States. This study evaluated accuracy integrated proteomic classifier identifying benign patients pretest probability cancer (pCA) ≤ 50%.A prospective, multicenter observational trial 685 8- to 30-mm lung was conducted. Multiple reaction monitoring mass spectrometry used measure relative abundance two plasma proteins, LG3BP and C163A. Results were clinical risk prediction model identify...
Abstract The contribution of emphysema to lung cancer risk has been recognized, but the effect size needs be further defined. In this study, 565 primary cases were enrolled though a prospective cohort at Mayo Clinic, and 450 controls smokers participating in screening study same institution using spiral computed tomography (CT). Cases frequency matched on age, gender, race, smoking status, residential region. CT imaging standard protocol time diagnosis (case) or during (control) was assessed...
<ns4:p>Most patients with lung cancer are diagnosed when they present symptoms, have advanced stage disease, and curative treatment is no longer an option. An effective screening test has long been desired for early detection the goal of reducing mortality from cancer. Sputum cytology, chest radiography, computed tomography (CT) scan studied as potential tests. The National Lung Screening Trial (NLST) demonstrated a 20% reduction in low-dose CT (LDCT) screening, guidelines now endorse annual...