A5030584988- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Acute Ischemic Stroke Management
- Aortic Thrombus and Embolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Head and Neck Cancer Studies
- Intracranial Aneurysms: Treatment and Complications
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Global Cancer Incidence and Screening
- Cerebrovascular and Carotid Artery Diseases
- Meta-analysis and systematic reviews
- Cancer Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Eosinophilic Disorders and Syndromes
- Vascular Malformations Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Management of metastatic bone disease
- Smoking Behavior and Cessation
- Meningioma and schwannoma management
- Gastrointestinal Tumor Research and Treatment
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Blood Pressure and Hypertension Studies
Brown University
2007-2020
John Brown University
2012-2013
Department of Medical Sciences
1999-2006
Mayo Clinic
1999-2004
Mayo Clinic in Florida
2003
Fundación Juan March
2001
Lung cancer is the largest contributor to mortality from cancer. The National Screening Trial (NLST) showed that screening with low-dose helical computed tomography (CT) rather than chest radiography reduced lung We describe screening, diagnosis, and limited treatment results initial round of in NLST inform improve lung-cancer-screening programs.
<h3>Importance</h3> Screening for lung cancer has the potential to reduce mortality, but in addition detecting aggressive tumors, screening will also detect indolent tumors that otherwise may not cause clinical symptoms. These overdiagnosis cases represent an important harm of because they incur additional cost, anxiety, and morbidity associated with treatment. <h3>Objective</h3> To estimate National Lung Trial (NLST). <h3>Design, Setting, Participants</h3> We used data from NLST, a...
There is scant population-based information on incidence and risk factors for ischemic stroke subtypes.We identified all 454 residents of Rochester, Minn, with a first between 1985 1989 from the Rochester Epidemiology Project medical records linkage system. We used Stroke Data Bank criteria to assign infarct subtypes after reviewing brain imaging. adjusted average annual rates by age sex US 1990 population compared age-adjusted frequency across subtypes.Age- sex-adjusted (per 100 000...
The National Lung Screening Trial was conducted to determine whether three annual screenings (rounds T0, T1, and T2) with low-dose helical computed tomography (CT), as compared chest radiography, could reduce mortality from lung cancer. We present detailed findings the first two incidence T1 T2). evaluated rate of adherence participants screening protocol, results downstream diagnostic tests, features lung-cancer cases, first-line treatments, we estimated performance characteristics both...
Mortality after cerebral infarction (CI) has remained unchanged during the past 20 years, despite advances in neurologic care. Key factors affecting survival may be underrecognized. The purpose of this study was to determine rate and cause mortality first CI.In case-control, population-based study, all available medical records were reviewed for Rochester (Minnesota) residents with a CI between 1985 1989 identify morbidities death. Predictors analyzed.First recorded 444 patients. Survival...
Abstract —At the community level, effect of national programs in increasing hypertension awareness, prevention, treatment, and control is unclear. This study evaluated degree detection high blood pressure a random population-based sample Olmsted County, Minnesota, residents ≥45 years old, whom 636 subjects among 1245 eligible agreed to participate. Home interview home office measurements were used estimate rates for community. Mean pressures (±SD) 138/80±20/12 mm Hg men 137/76±23/11 women....
We investigated the correlation between metabolic response by <sup>18</sup>F-FDG PET and objective response, glucose transporter type 4 (GLUT4) expression, <i>KIT/PDGFRA</i> mutation status in patients with gastrointestinal stromal tumor undergoing neoadjuvant imatinib mesylate therapy. <b>Methods:</b><sup>18</sup>F-FDG was performed at baseline, 1–7 d, or 8 wk after initiation. Best defined version 1.0 of Response Evaluation Criteria Solid Tumors (RECIST). Mutational analysis GLUT4...
Purpose Optimization of the clinical management screen-detected lung nodules is needed to avoid unnecessary diagnostic interventions. Herein we demonstrate potential value a novel radiomics-based approach for classification indeterminate nodules. Material and methods Independent quantitative variables assessing various radiologic nodule features such as sphericity, flatness, elongation, spiculation, lobulation curvature were developed from NLST dataset using 726 (all ≥ 7 mm, benign, n = 318...
Lung screening is an opportunity for smoking cessation and relapse prevention, but behaviors may differ across results. Changes in were evaluated among 18 840 current former smokers aged 55–74 scheduled to receive three annual lung screenings. Participants randomized low-dose computed tomography or single-view chest radiography the American College of Radiology/National Screening Trial. Outcome measures included point sustained (6-month) abstinence motivation quit smokers; who during...
Abstract OBJECTIVE To report presenting clinical symptoms, previous medical history, and survival rates for people with saccular intracranial aneurysms (IAs), in a defined population. METHODS The records of all residents Olmsted County, Minnesota, possible IAs were reviewed. Clinical manifestations at the time diagnosis, demographic factors, after diagnosis determined. RESULTS Of 270 detected between 1965 1995, 188 exhibited symptoms including 74% women 63% men (P = 0.054). Intracranial...
IntroductionIn the National Lung Screening Trial (NLST) all cases with a 4-mm nodule (micronodule) and no other findings were classified as negative study. The prevalence malignant potential of micronodules in NLST is evaluated to understand if this classification was appropriate.Methods MaterialsIn total 53,452 participants enrolled 26,722 undergoing low-dose computed tomography (CT) screening. To determine whether micronodule developed into lung cancer, list from database those who cancer...
Objective FDG‐PET/CT (fluorodeoxyglucose–positron emission tomography/computed tomography) is effective to assess for occult neck nodal disease. We report risks and patterns of disease based on primary site level from data the dissected cN0 per results ACRIN 6685. Study Design Prospective nonrandomized enrollment included participants with first‐time head squamous cell carcinoma at least 1 side be dissected. Setting Twenty‐four ACRIN‐certified centers internationally (American College...