A5011758100- AI in cancer detection
- Digital Radiography and Breast Imaging
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging Techniques and Applications
- Anesthesia and Pain Management
- Colorectal Cancer Screening and Detection
- Advanced X-ray and CT Imaging
- Hemodynamic Monitoring and Therapy
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Radiation Dose and Imaging
- Global Cancer Incidence and Screening
- Statistical Methods in Clinical Trials
- Anatomy and Medical Technology
- Advanced Causal Inference Techniques
- Meta-analysis and systematic reviews
- Ultrasound and Hyperthermia Applications
- Health Systems, Economic Evaluations, Quality of Life
- Neurotransmitter Receptor Influence on Behavior
- Pain Management and Opioid Use
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Skin Protection and Aging
- Pain Mechanisms and Treatments
Biostatistical Consulting (United States)
2008-2023
University of Pennsylvania
2019
Statistics Collaborative
2009-2012
Brown University
2001-2010
Mallinckrodt (United States)
2008
Beth Israel Deaconess Medical Center
2008
Memorial Medical Center
2008
Mayo Clinic in Arizona
2008
Mayo Clinic
2008
Abbott Northwestern Hospital
2008
Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as tool asymptomatic adults has not been well defined.
The development and implementation of quantitative imaging biomarkers has been hampered by the inconsistent often incorrect use terminology related to these markers. Sponsored Radiological Society North America, an interdisciplinary group radiologists, statisticians, physicists, other researchers worked develop a comprehensive serve as foundation for biomarker claims. Where possible, this working adapted existing definitions derived from national or international standards bodies rather than...
To evaluate the use of artificial intelligence (AI) to shorten digital breast tomosynthesis (DBT) reading time while maintaining or improving accuracy.A deep learning AI system was developed identify suspicious soft-tissue and calcified lesions in DBT images. A reader study compared performance 24 radiologists (13 whom were subspecialists) 260 examinations (including 65 cancer cases) both with without AI. Readings occurred two sessions separated by at least 4 weeks. Area under receiver...
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into clinical trial South Africa, 15-fold higher than trials before Omicron. also found lower CD4 + T-cell counts persons with human immunodeficiency virus (HIV) strongly correlated increased odds of SARS-CoV-2 polymerase chain reaction (PCR) positive.
CD4 + T cells can eliminate tumor in vivo the absence of CD8 cells. We have specific for a MHC class II-restricted, tumor-specific peptide derived from mutant ribosomal protein expressed by UV light-induced 6132A-PRO. By using neutralizing mAb murine IFN-γ and adoptive transfer into severe combined immunodeficient mice, we show that anti-IFN-γ treatment abolishes cell-mediated rejection . The were II negative, did not induce expression vitro Therefore, antigenic must be presented host Tumor...
As observed for many types of cancers, heritable variants ultraviolet light-induced tumors often grow more aggressively than the parental tumors. The aggressive growth some is due to loss a T cell-recognized tumor-specific antigen; however, other retain such antigens. We have analyzed an antigen retention variant and found that tumor cells at same rate as in vitro, but grew rapidly cell-deficient host. was stimulated vitro by factors released from tumor-induced leukocytes several defined...
Methylnaltrexone is a quaternary opioid antagonist with limited ability to cross the blood-brain barrier and potential antagonize peripherally mediated effects of opioids. The effectiveness methylnaltrexone in preventing morphine-induced changes gastrointestinal motility transit without affecting analgesia was evaluated humans. Twelve healthy volunteers were given intravenous placebo, placebo plus 0.05 mg/kg morphine, or 0.45 morphine. Oral-cecal time assessed by pulmonary hydrogen...
To demonstrate the safety and effectiveness of MelaFind, a noninvasive objective computer-vision system designed to aid in detection early pigmented cutaneous melanoma.A prospective, multicenter, blinded study. The diagnostic performance MelaFind study clinicians was evaluated using histologic reference standard. Standard images patient information for subset 50 randomly selected lesions (25 melanomas) were used reader 39 independent dermatologists estimate clinicians' biopsy sensitivity...
Although recognition and curative treatment of both precursor adenomas localized cancers are possible through early-detection, regular screening reduces mortality from colorectal cancer, is largely underused. Reasons for underuse include performance drawbacks issues comfort, availability, expense. Computed tomographic (CT) colonography an alternative that provides minimally invasive, structural evaluation the entire colorectum, permits rapid imaging colorectum without sedation, with few...
The purpose of this study was to compare the diagnostic accuracy dual-energy contrast-enhanced digital mammography (CEDM) as an adjunct (MX) ± ultrasonography (US) with MX US alone.One hundred ten consenting women 148 breast lesions (84 malignant, 64 benign) underwent two-view CEDM in addition and using a specially modified system (Senographe DS, GE Healthcare). Reference standard histology for 138 follow-up 12 lesions. Six radiologists from 4 institutions interpreted images high-resolution...
OBJECTIVE. The purpose of this study was to assess the diagnostic performance supplemental screening molecular breast imaging (MBI) in women with mammographically dense breasts after system modifications permit radiation dose reduction.
Methylnaltrexone is a quaternary opioid antagonist with limited ability to cross the blood-brain barrier that has potential antagonize peripherally mediated gastrointestinal effects of opioids. In recent trials in human volunteers, we demonstrated intravenous methylnaltrexone prevented morphine-induced changes gastroin-testinal motility and transit, without affecting analgesia. this study, 14 healthy volunteers were first given three ascending oral doses obtain safety tolerance data (phase A...
Propofol (P) and midazolam (M) are frequently given by continuous infusion for sedation in critically ill, mechanically ventilated patients. We compared these drugs with regard to: (1) time-to-awaken; (2) reproducibility of bedside assessments level sedation; (3) time-to-sedation; (4) change oxygen consumption (V O2) from awake to sedated state. Seventy-three patients were prospectively randomized receive either P (n=37) or M (n=36). Wake-up times after stopping the drug assessed blinded...
PURPOSE: To evaluate whether computer-aided diagnosis can reduce interobserver variability in the interpretation of mammograms. MATERIALS AND METHODS: Ten radiologists interpreted mammograms showing clustered microcalcifications 104 patients. Decisions for biopsy or follow-up were made with and without a computer aid, these decisions compared. The was used to estimate likelihood that microcalcification cluster due malignancy. Variability radiologists' recommendations versus then analyzed....
Purpose: The purpose of this study was to investigate the correlation between model observer and human performance in CT imaging for task lesion detection localization when location is uncertain. Methods: Two cylindrical rods (3-mm 5-mm diameters) were placed a 35 × 26 cm torso-shaped water phantom simulate lesions with −15 HU contrast at 120 kV. scanned 100 times on 128-slice scanner each four dose levels (CTDIvol = 5.7, 11.4, 17.1, 22.8 mGy). Regions interest (ROIs) around extracted...
Digital breast tomosynthesis (DBT) is more accurate than full-field digital mammography alone but requires a longer reading time. A radiologist reader study evaluated the use of concurrent computer-aided detection (CAD) to shorten time while maintaining interpretation performance.A CAD system was developed detect suspicious soft-tissue densities in DBT planes. Abnormalities are extracted from plane which they detected and blended into corresponding synthetic image. The used an enriched...
We analyzed 50 sets of ankle radiographs to determine the interobserver and intraobserver reliability when obtaining common linear angular measurements. The were divided into two groups: one group included 25 normal ankles, second fractured ankles. Each set was evaluated independently by four different observers on separate occasions under controlled conditions. Six radiographic parameters measured all films: syndesmosis A, B, C, medial clear space, talocrural bimalleolar angles. On fracture...