Personalized theranostics of cancer is increasingly desired, and can be realized by virtue multifunctional nanomaterials with possible high performances. Gold nanoparticles (GNPs) are a type especially promising candidate for theranostics, because their synthesis modification facile, structures physicochemical properties flexibly controlled, they also biocompatible. Especially, the localized surface plasmon resonance multivalent coordination effects on endow them NIR light-triggered...

Enzyme-photocoupled catalytic systems (EPCSs), combining the natural enzyme with a library of semiconductor photocatalysts, may break constraint evolution, realizing sustainable solar-to-chemical conversion and non-natural reactivity enzyme. The overall efficiency EPCSs strongly relies on shuttling energy-carrying molecules, e.g., NAD+/NADH cofactor, between active centers photocatalyst. However, few efforts have been devoted to shuttling. Herein, we propose strategy constructing thylakoid...

ConspectusLife activities, such as respiration, are accomplished through the continuous shape modulation of cells, tissues, and organs. Developing smart materials with shape-morphing capability is a pivotal step toward life-like systems emerging technologies wearable electronics, soft robotics, biomimetic actuators. Drawing inspiration from vesicular have been assembled to mimic biological modulation. This would enable understanding cellular adaptation guide design capability. Polymer...

In this study, we report novel multifunctional nanoagents for in vivo enzyme-responsive anticancer drug delivery and magnetic resonance imaging (MRI), based on mesoporous silica coated iron oxide nanoparticles (Fe3O4@MSNs).The drug, DOX, was encapsulated the porous cavities with a MMP-2 enzyme responsive peptide being covalently linked to surface.The vitro experiment results indicated that own high specificity controlled release cell line expression.Furthermore, targeted of tumor site...

The near-infrared localized surface plasmon resonance and magnetism of Cu_2−xSe nanoparticles was tuned by doping with Fe³⁺ ions. resultant multifunction hybrid nanostructure demonstrated to be a novel nanotheranostic agent for imaging-guided photothermal therapy cancer.

Metal ion-induced peptide assembly is an interesting field. As compared to traditional antibacterial Ag+, rare earth metal ions possess the advantage of performance with photostability and low toxicity. Herein, a new Fmoc-FFWDD-OH was designed synthesized, which could form stable hydrogel induced by ions, including Tb3+, Eu3+, La3+. The mechanical properties were characterized rheological measurements, they exhibited elasticity-dominating properties. Transmission electron microscopy (TEM)...

The timing of the final assembly China-Mongolia Block remains a subject debate. This work presents zircon U-Pb-Lu-Hf isotopes, whole-rock major and trace element data granitoid samples from north Erenhot, within Uliastai continental margin. Zircon U-Pb dating indicates that intrusive granitoids was in Pennsylvanian (318-298 Ma). Most are metaluminous to slightly peraluminous, exhibiting depletions Nb-Ta-Ti-Sr-P enrichments Rb-Th positive <mml:math...

Abstract Biomembrane curvature formation has long been observed to be essential in the change of membrane morphology and intracellular processes. The significant importance attracted scientists from different backgrounds study it. Although magnificent progress achieved using liposome models, instability these models restrict further exploration. Here, we report a new approach mimic biomembrane polymersomes as model, poly(N-isopropylacrylamide) induce local based on its co-nonsolvency...

Abstract Covalent and non-covalent molecular binding are two strategies to tailor surface properties functions. However, the lack of responsiveness requirement for specific groups makes spatiotemporal control challenging. Here, we report adaptive insertion a hydrophobic anchor into poly(ethylene glycol) (PEG) host as strategy functionalization. By using polycyclic aromatic hydrocarbons anchor, hydrophilic charged non-charged functional modules were spontaneously loaded onto PEG corona in 2...

The field of supramolecular chemistry has witnessed tremendous progress in bringing the system away from equilibrium for traditionally inaccessible structures and functions. Vesicular assemblies with complex energy landscapes pathways, which are reminiscent diverse cellular vesicles like exosomes, remain exceedingly rare. Here, relying on activation oligo(ethylene glycol) (OEG) interdigitation encoded conformational freedom monodisperse Janus dendrimers, we reveal a rich landscape pathway...

TCbHP (taxane + carboplatin trastuzumab pertuzumab) is the preferred neoadjuvant therapy regimen for human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, no consensus exists regarding whether specific populations may be exempt from carboplatin, allowing de-escalation to THP regimen. Additionally, optimal number of cycles remains unclear. We compared efficacy and safety regimens, providing clinicians with a nuanced perspective guide their treatment selection.

Abstract The enhanced membrane stability and chemical versatility of polymeric vesicles have made them promising tools in micro/nanoreactors, drug delivery, cell mimicking, etc. However, shape control over polymersomes remains a challenge has restricted their full potential. Here we show that local curvature formation on the can be controlled by applying poly( N -isopropylacrylamide) as responsive hydrophobic unit, while adding salt ions to modulate properties its interaction with membrane....

An adaptive surface that can sense and respond to environmental stimuli is integral smart functional materials. Here, we report pH-responsive anchoring systems onto the poly(ethylene glycol) (PEG) corona of polymer vesicles. The hydrophobic anchor, pyrene, reversibly inserted into PEG through reversible protonation its covalently linked pH-sensing group. Depending on pKa sensor, region engineered from acidic neutral basic conditions. switchable electrostatic repulsion between sensors...

Abstract Nanocontainers that can sense and respond to environmental stimuli like cells are desirable for next‐generation delivery systems. However, it is still a grand challenge synthetic nanocontainers mimic or even surpass the shape adaption of cells, which may produce novel compartments cargo loading. Here, this work reports engineering compartment network with single polymer vesicle by unraveling osmotic stress‐dependent deformation. Specifically, manipulating way in exerting stress,...

Herein, a facile and generic method is developed to prepare ultrathin, robust nanohybrid capsules by manipulating the dynamic structure of supramolecular nanocoatings on CaCO3 sacrificial templates incorporating multivalent–anion substitution process into biomineralization. Above biomineralization level, multivalent anions, for example, phosphate, sulfate, or citrate, are used initiate assembly polyamine continuous (nonsegregated) polyamine-anion templates. When contacting with sodium...

Plasmonic fishnet structures are proposed to realize dual-band terahertz (THz) left-handed metamaterials (LHMs). The calculated permittivity ε and permeability μ of single-layer LHMs show that &lt; 0 can be simultaneously satisfied in two frequency bands, resulting LHMs. electric magnetic field distributions consistent with the current confirm physical mechanism negative permeability. Furthermore, existence refraction is validated by a stacked prism an angle 1.79°. It shown at 2.04–2.42 THz...

Polymer Vesicles In article number 2306219, Daniela A. Wilson and co-workers report the programmable engineering of compartment networks achieved through stress-dependent deformation polymer vesicles. vesicles can be transformed either a tubulation pathway by applying mild osmotic stress or deflation an shock. The dependency enables sequential coupling two pathways for production networks.

As is well known, solar radiation the primary energy source on earth.Green plants/microorganisms have evolved efficient photosystems to convert CO2 into carbohydrates through accurately regulating photosynthesis process, i.e., photoelectrocatalytic process and multienzyme catalytic process.Inspired by photosynthesis, integrated enzyme-photocatalysis systems are constructed for balancing carbon cycle, which negatively influenced excessive burning of fossil fuels.From technological viewpoint,...