A5031564575- Bone and Dental Protein Studies
- dental development and anomalies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Oral and Maxillofacial Pathology
- Nanocluster Synthesis and Applications
- Synthesis and Catalytic Reactions
- Catalytic Processes in Materials Science
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Electrocatalysts for Energy Conversion
- Asymmetric Hydrogenation and Catalysis
- Luminescence and Fluorescent Materials
- Carbon and Quantum Dots Applications
- Zeolite Catalysis and Synthesis
- Crystallography and molecular interactions
- Mesoporous Materials and Catalysis
- Advanced Nanomaterials in Catalysis
- Periodontal Regeneration and Treatments
- Photosynthetic Processes and Mechanisms
- Plant Water Relations and Carbon Dynamics
- Nanomaterials for catalytic reactions
- Molecular Sensors and Ion Detection
- Phagocytosis and Immune Regulation
Dalian Polytechnic University
2025
Shenzhen University
2025
Zhongshan People's Hospital
2023-2025
Foshan University
2025
Soochow University
2009-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Xuzhou Medical College
2020-2024
Karamay Central Hospital of Xinjiang
2024
Ruijin Hospital
2024
ConspectusTraditional organic synthesis relies heavily on the transformations of various preinstalled functional groups, such as cross-coupling reactions using organohalides and organometallic reagents. The strategy C–H activation enables direct formation C–C/C–X (X = heteroatom) bonds from inert bonds, which can enhance atom- step-economy synthesis. To date, precious metals have overwhelmingly dominated field; however, rarity high cost these necessitate development more sustainable...
Herein, a manganese-catalyzed nucleophilic addition of inert C(sp(2))-H bonds to aldehydes and nitriles is disclosed by virtue dual activation strategy. The reactions feature mild reaction conditions, excellent regio- stereoselectivity, wide substrate scope, which includes both aromatic olefinic C-H bonds, as well large variety nitriles. Moreover, mechanistic studies shed light on possible catalytic cycles.
Glioblastoma multiforme (GBM) is the most common and fatal primary malignant central nervous system tumor in adults. Although there are multiple treatments, median survival of GBM patients unsatisfactory, which has prompted us to continuously investigate new therapeutic strategies, including drugs drug delivery approaches. Ferroptosis, a kind regulated cell death (RCD), been shown be dysregulated various tumors, GBM. Fatostatin, specific inhibitor sterol regulatory element binding proteins...
Patients with acute kidney injury (AKI) requiring initiation of renal replacement therapy (RRT) have poor short- and long-term outcomes, including the development dialysis dependence. Currently, little is known about what factors may predict recovery in this population.We conducted a single-center, retrospective analysis 170 hospitalized adult patients AKI attributed to tubular necrosis who required inpatient RRT. Data collection included patient characteristics, laboratory data, details...
ABSTRACT This study evaluated the acute toxicity and biokinetics of intravenously administered silver nanoparticles (AgNPs) in mice. Mice were exposed to different dosages AgNPs (7.5, 30 or 120 mg kg −1 ). Toxic effects assessed via general behavior, serum biochemical parameters histopathological observation Biokinetics tissue distribution at a dose both male female Inductively coupled plasma–mass spectrometry (ICP‐MS) was used determine concentrations blood samples collected predetermined...
Enamelin is critical for proper dental enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis imperfecta. We used targeting to generate a knock-in mouse carrying null allele of (Enam) that has lacZ reporter replacing Enam translation initiation site sequences through exon 7. Correct transgene was confirmed by Southern blotting PCR analyses. No protein could be detected Western Enam-null mice. Histochemical...
Kallikrein 4 (Klk4) is believed to play an essential role in enamel biomineralization, because defects KLK4 cause hypomaturation amelogenesis imperfecta. We used gene targeting generate a knockin mouse that replaces the Klk4 sequence, starting at translation initiation site, with lacZ reporter gene. Correct of transgene was confirmed by Southern blot and PCR analyses. Histochemical X-gal (5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside) staining demonstrated expression beta-galactosidase...
Selectivity control of varied C-H bonds in a complex molecule is long-standing goal and still great challenge activation field. Most often, such selectivity achieved by the innate reactivity different bonds. In this context, classic Mannich reaction acetophenone derivatives imines ascribed to more reactive C(sp3)-H α carbonyl, with much less aromatic C(sp2)-H remaining intact. Herein we report an addition ketones enabled manganese catalysis, which totally reverses carbonyl those on ring....
With the applications of quantum dots (QDs) expanding, many studies have described potential adverse effects QDs, yet little attention has been paid to toxicity QDs in liver. The aim this study was investigate cadmium telluride (CdTe) mice and murine hepatoma cells alpha mouse liver 12 (AML 12). CdTe administration significantly increased level lipid peroxides marker malondialdehyde (MDA) livers treated mice. Furthermore, caused cytotoxicity AML a dose- time-dependent manner, which likely...
Lower-grade glioma (LGG) is a common malignant primary tumour in the central nervous system, and most patients eventually develop highly aggressive gliomas despite comprehensive traditional treatment. Tumour molecular subtypes prognostic biomarkers play crucial role LGG diagnosis Therefore, identification of novel for predicting prognosis glioma. Immunogenic cell death (ICD) defined as regulated that sufficient to activate adaptive immune response immunocompetent hosts. The combination ICD...
UV light induces a delayed and prolonged (3-20 h) activation of NFkappaB when compared with the immediate acute (10-90 min) in response to tumor necrosis factor alpha treatment. In early phase (3-12 activation, reduces inhibitor (IkappaB) through an IkappaB kinase-independent, but polyubiquitin-dependent, pathway. However, mechanism for light-induced reduction is not known. this report, we show that down-regulates total amount decreasing mRNA translation. Our data inhibits translation...
Mesoporous core–shell composites with large-pore silica shells are highly desired for a broad spectrum of applications. We report an ultra-dilute liquid-phase coating strategy in acidic medium controllable synthesis uniform micro/mesoporous zeolite@SBA-15 comprising zeolite cores and mesoporous SBA-15 using triblock compolymer Plunoric P123 as template. Structural characterizations show that the possess tunable specific surface areas (115–228 m2 g−1), large pores (∼7.0 nm diameter) plenty...
Abstract A series of core–shell‐structured composite molecular sieves comprising zeolite single crystals (i.e., ZSM‐5) as a core and ordered mesoporous silica shell were synthesized by means surfactant‐directed sol–gel process in basic medium using cetyltrimethylammonium bromide (CTAB) template tetraethylorthosilicate (TEOS) precursor. Through this coating method, uniform shells closely grow around the anisotropic crystals, thickness which can easily be tuned range 15–100 nm changing ratio...
A facile method is developed for one-pot preparation of hierarchical dendritic PtPd nanogarlands supported on RGO, which shows superior electrocatalytic performances electrooxidation methanol and ethanol.
Enamel-renal syndrome (ERS) is an autosomal recessive disorder characterized by severe enamel hypoplasia, failed tooth eruption, intrapulpal calcifications, enlarged gingiva, and nephrocalcinosis. Recently, mutations in FAM20A were reported to cause amelogenesis imperfecta gingival fibromatosis (AIGFS), which closely resembles ERS except for the renal calcifications. We three families with AIGFS identified, each case, mutations: family 1 (c.992G>A; g.63853G>A; p.Gly331Asp), 2 (c.720-2A>G;...
WNT10A is a signaling molecule involved in tooth development, and defects are associated with agenesis. We characterized Wnt10a null mice generated by the knockout mouse project (KOMP) six families mutations, including novel p.Arg104Cys defect, absence of EDA, EDAR, or EDARADD variations. exhibited supernumerary mandibular fourth molars, smaller molars abnormal cusp patterning root taurodontism. Wnt10a−/− incisors showed distinctive apical–lingual wedge-shaped defects. These findings spurred...