A5058903262- Glaucoma and retinal disorders
- Numerical methods in inverse problems
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Photoacoustic and Ultrasonic Imaging
- Ophthalmology and Eye Disorders
- Optical Imaging and Spectroscopy Techniques
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Electromagnetic Scattering and Analysis
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Microwave Imaging and Scattering Analysis
- Ocular Diseases and Behçet’s Syndrome
- Radiative Heat Transfer Studies
- Cerebral Venous Sinus Thrombosis
- Thermography and Photoacoustic Techniques
- Endoplasmic Reticulum Stress and Disease
- Electrical and Bioimpedance Tomography
- Model Reduction and Neural Networks
- Advanced Wireless Network Optimization
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Electromagnetic Simulation and Numerical Methods
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Auburn University
2023-2025
Sun Yat-sen University
2015-2025
Chongqing University of Posts and Telecommunications
2025
Sinolight (China)
2024
University of California, Irvine
2019-2022
Michigan State University
2021
Duke University
2021
DePaul University
2021
Background: In recent years, the flipped classroom method of teaching has received much attention in health sciences education. However, application classrooms ophthalmology education not been well investigated.Objective: The goal this study was to investigate effectiveness and acceptability approach at clerkship level.Design: Ninety-five fourth year medical students an were randomly divided into two groups. An ocular trauma module chosen for content study. One group (FG (flipped group), n =...
Inflammation plays an important role in diabetes-induced retinal vascular leakage. The purpose of this study is to examine the endoplasmic reticulum (ER) stress and signaling pathway ER stress-induced activating transcription factor 4 (ATF4) regulation Müller cell-derived inflammatory mediators diabetic retinopathy. In animals, elevated markers, ATF4, endothelial growth (VEGF) expression were partially localized cells retina. cultured cells, high glucose induced a time-dependent increase...
Damage to the retinal pigment epithelium (RPE) is an early event in pathogenesis of age-related macular degeneration (AMD). X-box binding protein 1 (XBP1) a key transcription factor that regulates endoplasmic reticulum (ER) homeostasis and cell survival. This study aimed delineate role endogenous XBP1 RPE. Our results show rat model light-induced degeneration, activation was suppressed RPE/choroid complex, accompanied by decreased anti-oxidant genes increased oxidative stress. Knockdown...
Sanguisorba officinalis L. (S. officinalis) has been widely distributed in various regions of China and holds significant potential for applications. However, limited studies have focused on S. polysaccharides (SOPs) their biological activities. Utilizing response surface methodology (RSM), the process ultrasonic-assisted extraction SOPs was optimized. The optimal conditions were 270.2 W, 42.4 mL/g, 47.7 min. Through separation purification, a neutral polysaccharide named SOUP-1 obtained....
Congenital fibrovascular pupillary membranes in secondary glaucoma (CFPMSG) is kind of refractory childhood glaucoma. The aim the study to evaluate efficacy and safety Ahmed valve (AGV) implants CFPMSG. Twelve patients with CFPMSG who underwent anterior chamber reconstruction (ASR) a stable but uncontrolled intraocular pressure (IOP) AGV implantation. Patients follow-up period > 12 months were enrolled. Demographic data collected. All comprehensive ophthalmic examinations before after...
Globally, lung cancer is the primary cause of deaths associated with cancer; however, current therapies are costly and toxic, highlighting need for novel treatments. Peiminine (Verticinone), a key bioactive compound derived from Fritillaria ussuriensis Maxim., has demonstrated diverse biological activities. However, precise pharmacological mechanisms underlying its anti-lung effects remain unclear. The objective this study was to quantify content peiminine in Maxim. different geographical...
Primary open angle glaucoma (POAG) is the leading cause of irreversible blindness. Dysfunction trabecular meshwork (TM), resulting in decreased outflow aqueous humor and increased intraocular pressure (IOP), plays an important role pathogenesis POAG. However, underlying mechanisms still remain unclear. In this study, we demonstrated that eIF2-α/ATF4/CHOP branch unfolded protein response (UPR) was activated human cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure. Inhibition ATF4...
To investigate the effects of sodium hyaluronate (SH) on ocular surface toxicity induced by benzalkonium chloride (BAC)-preserved latanoprost.Twenty-one white rabbits (42 eyes) were randomly divided into three groups. The control group was untreated. two experimental groups treated with 0.02% BAC-containing latanoprost once a day combined unpreserved 0.3% SH or PBS times daily for 60 days. Schirmer test, fluorescein and rose bengal staining, conjunctiva impression cytology performed days 0,...
To evaluate the causes of misdiagnosis in patients with acute angle-closure glaucoma secondary to subluxated lens, and postoperative outcomes.Retrospective clinical study.Five hundred twenty-six cases were consecutively recruited from Zhongshan Ophthalmic Center between March 2003 2009. Zonular dialysis, anterior chamber angle, depth examined by ultrasound biomicroscopy. Surgical therapy was performed according degree zonular dialysis angle closure.Thirty-one eyes (5.89%) lens subluxation...
We consider a switched (queuing) network in which there are constraints on queues may be served simultaneously; such networks have been used to effectively model input-queued switches and wireless networks. The scheduling policy for specifies serve at any point time, based the current state or past history of system. In main result this paper, we provide new class online policies that achieve optimal queue-size scaling including switches. particular, it establishes validity conjecture...
Fluorescence photoacoustic tomography (fPAT) is a molecular imaging modality that combines (PAT) with fluorescence to obtain high-resolution of distributions inside heterogeneous media.The objective this work study inverse problems in the quantitative step fPAT where we intend reconstruct physical coefficients coupled system radiative transport equations using internal data recovered from ultrasound measurements.We derive uniqueness and stability results on develop some efficient algorithms...
In this work, we study the instability of an inverse problem radiative transport equation with angularly independent source and averaged measurement near diffusion limit, i.e., normalized mean free path (the Knudsen number) $0 < \varepsilon \ll 1$. For reconstruction absorption coefficient, show that depends on relative sizes between $\varepsilon$ perturbation in measurements. When is sufficiently small, obtain exponential instability, which stands for regime, otherwise Hölder instead, regime.
Abstract Purpose The aim of this study was to describe the genetic and clinical characteristics Chinese patients with autosomal recessive bestrophinopathy ( ARB ). Methods This presents a retrospective observational case series. Twenty‐one 25 clinically healthy family members were recruited. coding regions adjacent intronic BEST 1 analysed via Sanger sequencing. Clinical examinations, including ultrasound biomicroscopy, A‐scan, optical coherence tomography, fundus autofluorescence,...
Normal function of the retinal pigment epithelium (RPE) is essential for maintaining structural integrity photoreceptors and visual process. Sustained oxidative damage RPE due to aging other risk factors contributes development age-related macular degeneration (AMD). The transcription factor NF-E2-related 2 (Nrf2) a central regulator cellular antioxidant detoxification responses. Enhancing Nrf2 protects cells from oxidation-related apoptosis cell death. Previously, we demonstrated that...
Purpose: To describe sequential phacoemulsification–intraocular lens (IOL) implantation–posterior capsulorhexis–anterior vitrectomy in the management of phakic malignant glaucoma. Methods: Twenty consecutive patients (25 eyes) with glaucoma were enrolled at Zhongshan Ophthalmic Center, Sun Yat-sen University. All underwent phacoemulsification, IOL implantation and posterior capsulorhexis together anterior via a clear corneal paracentesis. Visual acuity, intraocular pressure (IOP), chamber...
Long-term use of benzalkonium chloride (BAC)-preserved drugs is often associated with ocular surface toxicity. Ocular symptoms had a substantial impact on the glaucoma patients' quality life and compliance. This study aimed to investigate effects sodium hyaluronate (SH) toxicity induced by BAC-preserved anti-glaucoma medications treatment.Fifty-eight patients (101 eyes), who received topical treatment met severe dry eye criteria, were included in analysis. All maintained original treatment....
Purpose Trabeculectomy has been regarded as a mainstay of initial treatment in eyes angle closure glaucoma (ACG) with peripheral anterior synechia > 180° the Chinese population while its efficacy secondary ACG BEST1 gene mutation remains unclear. We set out to investigate outcome trabeculectomy for group patients autosomal recessive bestrophinopathy (ARB). Methods In this retrospective case series study, 8 ARB and their 4 recruited family members underwent thorough ophthalmic examination...