A5100786017- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Optical Coherence Tomography Applications
- Law in Society and Culture
- Medical Imaging Techniques and Applications
- HIV/AIDS drug development and treatment
- Ocular Infections and Treatments
- Extenics and Innovation Methods
- Cerebrovascular and genetic disorders
- HIV/AIDS Research and Interventions
- Retinopathy of Prematurity Studies
- Connective tissue disorders research
- Radiation Therapy and Dosimetry
- Ocular Oncology and Treatments
- Advanced Radiotherapy Techniques
- Traumatic Ocular and Foreign Body Injuries
- Ocular and Laser Science Research
Sun Yat-sen University
2014-2023
Zhongshan Ophthalmic Center, Sun Yat-sen University
2015-2018
Fudan University
2016
Stanford University
2005
The purpose of this study was to confirm previously reported associations common variants in or near CDC7/TGFBR3, ZP4, SRBD1, ELOVL5, CAV1/CAV2, TLR4, CDKN2B, CDKN2B-AS1, ATOH7, PLXDC2, TMTC2, SIX1, and CARD10, with primary open angle glaucoma (POAG) the Afro-Caribbean population Barbados, West Indies. A total 437 unrelated subjects from Barbados Family Study Open Angle Glaucoma (BFSG), including 272 POAG 165 unaffected individuals were included study. Eighteen SNPs genotyped by using...
Genetic factors have an important role in the development of glaucoma; however, exact genetic defects remain to be identified majority patients. Glaucoma is frequently observed patients with anterior segment dysgenesis (ASD), microcornea or microphthalmia. The present study aimed detect potential mutations genes associated ASD, and microphthalmia 257 glaucoma. Variants 43 46 genes, which are microphthalmia, were available whole‑exome sequencing. Candidate variants selected following...
The purpose is to assess the diagnostic ability for early glaucoma of macular ganglion cell–inner plexiform layer (GCIPL) thickness in a Chinese population including suspects. A total 367 eyes with primary open-angle (168 glaucoma, 78 moderate and 121 advanced glaucoma), 52 ocular hypertension (OHT), 59 enlarged cup-to-disc ratio (C/D), 225 normal were included. GCIPL (average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, inferotemporal), retinal nerve fiber (RNFL)...
To investigate whether image quality is an important determinant of retinal nerve fiber layer (RNFL) and macular thickness measurements on Fourier-domain optical coherence tomography (OCT).Seventy-five 56 normal subjects were recruited in RNFL arms the study, respectively. Each participant was scanned three times using both 3D OCT-1000 (version 3.01, Mark II; Topcon Corporation, Tokyo, Japan) Cirrus OCT 3.0, Model 4000; Carl Zeiss Meditec, Inc., Dublin, CA). The scans for each arranged order...
Abstract Purpose The aim of this study was to describe the genetic and clinical characteristics Chinese patients with autosomal recessive bestrophinopathy ( ARB ). Methods This presents a retrospective observational case series. Twenty‐one 25 clinically healthy family members were recruited. coding regions adjacent intronic BEST 1 analysed via Sanger sequencing. Clinical examinations, including ultrasound biomicroscopy, A‐scan, optical coherence tomography, fundus autofluorescence,...
Macular edema and detachment at the first day after an uneventful cataract surgery is very rare, has been reported previously with use of high concentrations intra-cameral cefuroxime. However, we hereby two cases macular extensive serous retinal phacoemulsification injection a standard dose cefuroxime during procedure. A 68-year-old female 63-year-old male without any special history both underwent 1 mg/0.1 ml solution was injected into anterior chamber end around macula optic disc area were...
To assess lens thickness (LT) measurements with anterior segment optical coherence tomography (AS-OCT) in comparison A-scan ultrasonography (A-scan US).Enrolled were 66 eyes of 48 phakic elderly volunteers aged > or = 50 years and 56 young participants 18 to 40 years. LT was measured the internal manual caliper tools AS-OCT. The US based on an average 10 consecutive automatic measurements. Reproducibility assessed by three each AS-OCT independently obtained two observers who masked one...
To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness obtained by spectral-domain optical coherence tomography (SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma (PPG) from highly healthy eyes.A total 254 eyes, including 76 normal controls (NC), 116 high myopia (HM) and 62 PPG were enrolled. The OCT parameters was accessed areas under receiver operating characteristic (AUROC) curve two distinguishing groups:...
<b><i>Purpose:</i></b> To assess the reproducibility of quantitative measurements foveal avascular zone (FAZ) and retinal vasculature determined by different scanning protocols optical coherence tomography angiography (OCTA) in healthy volunteers. <b><i>Method:</i></b> All participants were scanned two trained operators using an AngioPlex OCTA. Both (6 × 6 mm 3 mm) performed three times on same eye operator A one additional time B. The FAZ area...
Abstract Background Demographic, systemic and ocular factors may impact macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements. This study aimed to investigate the influences of multiple potential determinants GCIPL in normal Chinese adults. Methods was a retrospective conducted on 225 eyes from healthy were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular...
The current study highlights distinct choroidal alterations in primary open angle (POAG) and closure (PACG) glaucomas, underscoring the potential of Choroidal Vascularity Index (CVI) as a valuable indicator for understanding glaucoma pathogenesis.To evaluate structural changes patients with POAG PACG healthy controls utilizing CVI subfoveal thickness by enhanced depth imaging optical coherence tomography.This was cross-sectional. A total 171 eyes subjects, comprising 69 untreated POAG, 58...
To measure lamina cribrosa thickness (LCT) and anterior surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic angle-closure (CPACG), control patients using spectral-domain optical coherence tomography (SD-OCT) examine its association with relevant ocular parameters.In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG (65 55 CPACG (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way enhanced imaging Heidelberg SD-OCT. The obtained...
To test the hypothesis that amblyopic neuroretina may have an altered thickness when compared to normal.Twenty-five amblyopic, young patients between ages of 7 and 11 years old were studied. The interested areas are defined into 10 sub-regions according superior-inferior, nasal-temoral, peri-para axis, which cross fovela structure. thicknesses ten, macular regions separately measured by optical coherence tomography (OCT) analyzed t-test.The average in exact foveola eyes is larger than normal...
Purpose: To observe the relationship between characteristic changes in drusen morphology revealed by spectral-domain optical coherence tomography (SD-OCT) and progression of age-related macular degeneration (AMD). Methods: A total 380 45 eyes 35 patients with intermediate were longitudinally followed up every 6 months SD-OCT for a period 24 months. The divided into dynamic group stable according to following parameters: number, volume, concurrent retinal pigment epithelium (RPE)/ellipsoid...
To investigate the reproducibility of macular ganglion cell-inner plexiform layer (GCIPL) thickness measurement in normal eyes determined by different operators and two raster scanning protocols Cirrus high-definition optical coherence tomography (HD-OCT).One hundred 102 subjects were scanned three times using HD-OCT with Macular Cube 512 × 128 protocol operators, respectively. Three extra scans obtained 200 protocol. The average, minimum, superotemporal, superior, superonasal, inferonasal,...
To investigate the variation in central lamina cribrosa thickness (cLCT), and anterior surface depth (cALCSD), as well prelaminar tissue (cPLTT) related to age healthy Chinese subjects.A total of 96 eyes from subjects were recruited. According age, cases divided into three groups: young group (YG, 18-39y), middle-age (MG, 40-59y) older-age (OG, 60y above). Lamina images obtained all participants using radial linear protocol by enhanced imaging spectral-domain optical coherence tomography....
The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with without malignant (MG).In cross-sectional study, we enrolled 25 patients bilateral (PAC) diseases; 1 eye each patient diagnosed PACG initially later MG after trabeculectomy, fellow were PACG, PAC, or PAC suspect. Thirty-seven from 37 recruited as controls. CT measured at different locations (sub-fovea, 3 mm fovea) using spectral-domain optical coherence...
[Objective] To observe the effects of local macular foveal photoreceptor defects on visual acuity.[Methods] Thirty-one patients (31 eyes) with defect in fovea (case group)diagnosed by spectral domain optical coherence tomography (SD-OCT) and 30 (30 age-and diopter-matched normal subjects (control group) were enrolled this study.There 22 eyes full 9 outer segment case group.All examined for best corrected acuity (BCVA),slit-lamp microscopy,direct ophthalmoscope SD-OCT.Independent sample...