Gen Li

ORCID: 0000-0003-4665-7510
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About
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Research Areas
  • Bone Tissue Engineering Materials
  • Sports injuries and prevention
  • Electrospun Nanofibers in Biomedical Applications
  • 3D Printing in Biomedical Research
  • Sports Performance and Training
  • Tendon Structure and Treatment
  • Grit, Self-Efficacy, and Motivation
  • RNA Interference and Gene Delivery
  • Shoulder Injury and Treatment
  • Hematological disorders and diagnostics
  • Cardiovascular and exercise physiology
  • Shoulder and Clavicle Injuries
  • Wound Healing and Treatments
  • Tissue Engineering and Regenerative Medicine
  • Periodontal Regeneration and Treatments
  • Thallium and Germanium Studies
  • Bone and Joint Diseases
  • Magnesium Alloys: Properties and Applications
  • Medical and Biological Ozone Research
  • Transcranial Magnetic Stimulation Studies
  • Graphene and Nanomaterials Applications
  • Bone Metabolism and Diseases
  • Sports Dynamics and Biomechanics
  • Elbow and Forearm Trauma Treatment
  • Hemispheric Asymmetry in Neuroscience

Shanghai Jiao Tong University
2020-2024

Ruijin Hospital
2020-2024

University of South Florida
2024

South China Normal University
2023

Beijing Sport University
2023

Shanghai Tenth People's Hospital
2023

Tongji University
2023

Lanzhou Army General Hospital
2017

Metal ions are important trace elements in the human body, which directly affect metabolism and regeneration of damaged tissues. For instance, advanced combination magnesium (Mg2+) bone repair materials make composite have function promoting vascular enhancing adhesion osteoblasts. Herein, inspired by magnets to attract metals, we utilized coordination reaction metal ion ligand construct a bisphosphonate-functionalized injectable hydrogel microsphere (GelMA-BP-Mg) could promote cancellous...

10.1021/acsnano.1c02147 article EN ACS Nano 2021-08-03

Abstract Microfluidic hydrogel microspheres have been broadly studied across a wide range of industries and applications, their use in the medical field, including control cells drug delivery, is increasing. The usual design these materials intended to enable efficient smart encapsulation and/or drugs which functionalities features are effectively controlled, lending itself some unique properties. These characteristics promote exchanges cooperation multiple disciplines boost development...

10.1002/adfm.202103339 article EN Advanced Functional Materials 2021-05-13

Novel gradient bimetallic hydrogel promotes tendon-to-bone interface reconstruction by synchronous regeneration.

10.1126/sciadv.abg3816 article EN cc-by-nc Science Advances 2021-06-23

Abstract Metal ions play a significant role in tissue repair, with widely application clinical treatment. However, the therapeutic effect of metal is always limited due to metabolization and narrow repair capability. Here, bipolar flexible electrospun fibrous membrane based on metal–organic framework (MOF), which bioinspired by gradient structure tendon‐to‐bone interface, combination regulating osteoblasts differentiation angiogenesis properties, constructed successfully continuous...

10.1002/adhm.202200072 article EN Advanced Healthcare Materials 2022-03-14

In article number 2103339, Ming Cai, Wenguo Cui, and co-workers review the latest developments in controlled delivery of microfluidic hydrogel microspheres, medical applications microspheres to deliver cells drugs are emphasized. This encourages research on boost development precision medicine, new manufacturing technologies, applied materials.

10.1002/adfm.202170227 article EN Advanced Functional Materials 2021-08-01

Chronic and infectious wounds are major public health issues with financial clinical manifestations. Developing a multitasking extracellular matrix mimicking scaffold can bring revolution saving millions of lives. Many bioactive agents offering therapeutic promises in managing but require suitable delivery system to ensure not only their bioavailability possible on the wound site also control burst release hence making them either useless or highly cytotoxic. In this study, we reported dual...

10.1016/j.colsurfb.2023.113570 article EN cc-by-nc-nd Colloids and Surfaces B Biointerfaces 2023-09-27

Background: Large bone defects resulting from trauma and diseases still a great challenge for the surgeons. Exosomes modified tissue engineering scaffolds are one of promising cell-free approach repairing defects. Despite extensive knowledge variety kinds exosomes promote regeneration, little is known effect mechanism adipose stem cells-derived (ADSCs-Exos) on defect repair. This study aimed to explore whether ADSCs-Exos scaffold promotes Material/Methods: were isolated identified by...

10.3389/fbioe.2023.1096390 article EN cc-by Frontiers in Bioengineering and Biotechnology 2023-02-09

The intracellular delivery of messenger (m)RNA holds great potential for the discovery and development vaccines therapeutics. Yet, in many applications, a major obstacle to clinical translation mRNA therapy is lack efficient strategy precisely deliver RNA sequence liver tissues cells. In this study, we synthesized virus-like mesoporous silica (V-SiO2) nanoparticles effectively therapeutic RNA. Then, cationic polymer polyethylenimine (PEI) was included further surface modification (V-SiO2-P)....

10.3389/fbioe.2023.1160509 article EN cc-by Frontiers in Bioengineering and Biotechnology 2023-03-02

The purpose of the present study was to examine effects 6 weeks 40-, 60-, or 80-cm drop jump (DJ) training on lower limb explosive and change direction (CoD) performance in collegiate Sanda athletes. Repeated-measure ANOVA revealed that there a significant group × time interaction for standing long test (p = 0.006), counter movement 0.026), Illinois agility 0.003), square 0.018), Nebraska 0.027), t 0.032), hexagon 0.012) due best observed at post-test compared with pre-test DJ60 (effect size...

10.1016/j.isci.2023.107972 article EN cc-by-nc-nd iScience 2023-09-22

Objectives To compare the clinical outcomes of plate fixation and arthroscopic‐assisted in patients with displaced isolated medium‐sized fractures greater tuberosity. Methods From July 2013 to October 2017, tuberosity who underwent (ASPF group) or open reduction internal (ORIF were retrospectively reviewed analyzed. There 19 ASPF group 27 ORIF group, comparable demographic characteristics. The average age was 49.4 ± 12.1 years 46.9 11.4 group. shoulder function reflected by Constant–Murley...

10.1111/os.12773 article EN cc-by Orthopaedic Surgery 2020-10-01

To investigate the performance of loading naringin composite scaffolds and its effects on repair osteochondral defects.The unloading sustained release microspheres were prepared by W/O/W method; with materials attpulgite collagen type I, naringin, transforming growth factor β 1 (TGF-β 1) constructed respectively "3 layers sandwich method". The effect sustained-release microspheres, morphology scaffolds, biocompatibility evaluated releasing in vitro, scanning electron microscope, cell...

10.7507/1002-1892.201611112 article EN PubMed 2017-04-15

Quantification of fat fraction (FF) and R2* in areas bone marrow edema (BME) metaplasia different stages Ankylosing Spondylitis (AS). 75 AS 3 stage (early acute group, late stable group), 42 BME 39 were detected. Difference FF, compared relationship between FF analyzed. Result showed metaplasia, but not BME, is significantly negative with FF. measurements can quantitatively analyze component change AS.

10.58530/2022/3082 article EN Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition 2023-08-03

Since the 1980s, many scholars have studied fatigue from physiological and biochemical aspects. Exercise is a phenomenon caused by exercise stimulation. It reflects tolerance of body to positive process for regulate its own activities has an alarming effect on body's activities. Because appearance, it can reduce intensity exercise, or even stop movement, in order prevent excessive consumption substances damage function. The high load modern tennis training competition will inevitably lead...

10.12783/dtssehs/aems2018/27993 article EN DEStech Transactions on Social Science Education and Human Science 2019-02-25

Bioscaffolds This schematic diagram is to illustrate the repair effect of a bipolar fibrous membrane in ink painting style with Chinese characteristics. The sky and ground on both sides respectively represents tendon bone. Both MOF particles can promote tissue repair, phoenix used highlight particles. work be found article number 2200072 by Wenguo Cui, Yao Chen, Lei Wang, co-workers.

10.1002/adhm.202270063 article EN Advanced Healthcare Materials 2022-06-01

Abstract:Extrusion 3D printing hydrogels for tissue repair is a research hotspot in recent years.However, the high-fidelity hydrogel process still inseparable from complex cross-linking strategy, which greatly increases difficulty of and limits application field engineering.A that can be printed at room temperature prepared, achieved without any auxiliary during process.The composed gelatin methacrylate (GelMA), Laponite (LPN) methylcellulose (MC).The extrusion test screened out proportion...

10.3901/jme.2022.09.283 article EN Journal of Mechanical Engineering 2022-01-01
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