A5086865014- Resilience and Mental Health
- Family Caregiving in Mental Illness
- Family Support in Illness
- Grief, Bereavement, and Mental Health
- Health disparities and outcomes
- Advancements in Battery Materials
- Family and Disability Support Research
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Advanced Battery Materials and Technologies
- Migration, Health and Trauma
- COVID-19 and Mental Health
- Mental Health Treatment and Access
- Nanoparticle-Based Drug Delivery
- Supercapacitor Materials and Fabrication
- Land Use and Ecosystem Services
- Health, psychology, and well-being
- Optimism, Hope, and Well-being
- Ginseng Biological Effects and Applications
- Extracellular vesicles in disease
- Physical Activity and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Geriatric Care and Nursing Homes
- Simulation-Based Education in Healthcare
- Immune cells in cancer
Fudan University
2018-2025
Wuhan Sports University
2025
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Zhuhai People's Hospital
2024
Jinan University
2024
Capital Medical University
2019-2023
Michigan State University
2021-2023
China University of Geosciences (Beijing)
2022-2023
University of Chicago
2022-2023
Carbon dot is a type of carbon material with an ultrasmall size less than 10 nm for all three dimensions, which has attracted more and attention due to its useful merits. Unfortunately, the complicated synthesis method low yield largely limit wide large-scale application. Herein, inexpensive high-efficiency aldol condensation under ambient temperature pressure was proposed CDs, can obtain products 1.083 kg in 2 h realize functionalization dots doped nitrogen (NCDs) sulfur/nitrogen doubly...
The research progress on the factors restricting of LMFP rate performance has been comprehensively elaborated with respect to three aspects: intrinsic properties, interface structure and cell preparation.
Inherent or acquired resistance to paclitaxel (PTX) is a pivotal challenge for chemotherapy treatment of multidrug-resistant (MDR) breast cancer. Although various targeted drug-delivery systems, including nanoparticles and liposomes, are effective MDR cancer treatment, their efficacy restricted by immunosuppressive tumor microenvironment (TME).Ginsenosides Rg3 was used formulate unique Rg3-based liposomes loaded with PTX establish Rg3-PTX-LPs, which were prepared the thin-film hydration...
Abstract Fabrication of Bi/C composites is a common approach to alleviate the severe volume expansion Bi alloy‐based anodes with high theoretical capacity 3800 mAh cm −3 for lithium ion batteries (LIBs). However, complicated and tedious synthetic routes restrict its large‐scale preparation practical applications. Herein, spongiform porous composite (marked as Bi@PC) through carbothermal reduction (CTR) method constructed. nanodots are in situ confined carbon substrate activated by gases...
Abstract Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors. However, clinical therapeutic efficacy liposomes is still limited by complexity tumor microenvironment (TME) insufficient accumulation sites. Meanwhile, application cholesterol polyethylene glycol (PEG), which are usually used to prolong blood circulation stabilize structure respectively, has been questioned due various disadvantages. Herein, we developed a ginsenoside Rh2-based...
Abstract Cerebral ischemia/reperfusion (CI/R) injury is a clinical conundrum during the treatment of ischemic stroke. Cell-derived exosomes (CDE) were proved to be therapeutically effective for CI/R injury. However, production CDE time and effort consuming. Increasing studies reported that plants can also generate exosome-like nanoparticles (ELN) which are have higher yield compared with CDE. In this study, commonly used Chinese herb Panax notoginseng (PN), whose active ingredients...
Within the ovarian cancer tumor microenvironment, stem-like cells (CSC) interact with carcinoma associated mesenchymal stem/stromal (CA-MSC) through multiple secreted cytokines and growth factors. These paracrine interactions have been revealed to cause enrichment of CSC their chemoprotection; however, it is still not known if platelet-derived factor (PDGF) signaling involved in facilitating these responses. In order probe this undiscovered bidirectional communication, we created a model...
The chemotherapy effect of docetaxel (DTX) against triple-negative breast cancer (TNBC) remains mediocre and limited when encapsulated in conventional cholesterol liposomes, mainly ascribed to poor penetration immunosuppressive tumor microenvironment (TME) caused by stroma cells, especially cancer-associated fibroblasts (CAFs). Many studies have attempted address these problems but trapped into the common dilemma excessively complicated formulation strategies at expense druggability as well...
Carbon monoxide (CO) is highly toxic and lethal to humans animals because of its strong affinity for hemoglobin, while this "silent killer" constantly generated in the body as a cell-signaling molecule gasotransmitter family various pathological physiological conditions. Up now, designing fluorescent probes real-time imaging CO living species continuous challenge due background interference, light scattering, photoactivation/photobleaching. Herein, novel type bioluminescence probe...
To utilize the multiple functions and give full play of ginsenosides, a variety ginsenosides with different structures were prepared into liposomes evaluated for their effect on stability, pharmacokinetics tumor targeting capability liposomes. The results showed that position number glycosyl groups have significant in vitro vivo properties indicated C-3 sugar group is beneficial to longer circulation vivo. C-6 glycosyls can enhance uptake by 4T1 cells, at active ability significantly, based...
Abstract Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel (IBD) in almost 90% cases. Colorectal cancer a major complication patients PSC and IBD, these are at much greater risk compared to IBD without concomitant PSC. Combining flow cytometry, bulk single-cell transcriptomics, T B cell receptor repertoire analysis right colon tissue from 65 PSC, 108 48 healthy individuals we identified unique adaptive transcriptional...
Stable and sustainable food production is an important guarantee for national security social stability. The uneven distribution of cultivated land water resources will threaten security. In this study, we adopt the Gini coefficient water-land matching exploring nexus in main grain-producing areas North China Plain (NCP) from 2000 to 2020. water-land-food considering grain crop structure further explored spatial temporal multi-scales. results show following: (1) presents increasing trend...
Background: Most solid tumors are not diagnosed and treated until the advanced stage, in which have shaped mature self-protective power, leading to off-target drugs nanomedicines. In present studies, we established a more realistic large tumor model test antitumor activity of multifunctional ginsenoside Rh2-based liposome system (Rh2-lipo) on breast cancer. Methods: Both cholesterol PEG were substituted by Rh2 prepare Rh2-lipo using ethanol-water characterized. The effects cell uptake,...
Abstract Assistance for distressed caregivers can indirectly facilitate recovery of the people being cared for, yet how resilience, hope, and social support mediate between caregiving burden adjustment outcomes is unclear. A structural equation model was constructed based on data from a cross‐sectional survey 324 children adolescents with schizophrenia using multidimensional caregiver inventory, Connor‐Davidson resilience scale, Herth hope index, perceived distress management screening...
Hosting database services on cloud systems has become a common practice. This led to the increasing volume of workloads, which provides opportunity for pattern analysis. Discovering workload patterns from business logic perspective is conducive better understanding trends and characteristics system. However, existing discovery are not suitable large-scale databases commonly employed by industry. because generally far more complicated than those ordinary databases. In this paper, we propose...