A5101473848- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Cardiac Arrest and Resuscitation
- Proteoglycans and glycosaminoglycans research
- RNA Research and Splicing
- Circular RNAs in diseases
- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Animal Virus Infections Studies
- Cancer-related gene regulation
- Antibiotics Pharmacokinetics and Efficacy
- Natural Compounds in Disease Treatment
- Pancreatic and Hepatic Oncology Research
- Virus-based gene therapy research
- Sepsis Diagnosis and Treatment
- Advanced Glycation End Products research
- Medicinal Plant Pharmacodynamics Research
- Obesity, Physical Activity, Diet
- Pancreatitis Pathology and Treatment
Children's Hospital of Zhejiang University
2018-2025
Guangdong 999 Brain Hospital
2024
Shanghai Jiao Tong University
2011-2024
Anhui Medical University
2017-2024
First Affiliated Hospital of Anhui Medical University
2019-2024
Chongqing Jiulongpo People's Hospital
2024
Lingnan Normal University
2022
Guangdong Ocean University
2022
Nanjing University of Chinese Medicine
2021
Ruijin Hospital
2014-2018
Abstract Long noncoding RNA UCA1 has emerged as a novel regulator in cancer initiation and progression of various cancers. However, function underlying mechanism the gastric (GC) remain unclear. In present study, we report that expressed highly GC tissues cells, which was partly induced by SP1. promoted cell proliferation G1/S transition vitro vivo . Moreover, exerted its through interacting with EZH2, promoting direct interaction cyclin D1 promoter to activate translation D1. Furthermore,...
// Lei Hu 1,* , Yan-tao Duan Jian-fang Li 1 Li-ping Su Min Yan Zheng-gang Zhu Bing-ya Liu Qiu-meng Yang Shanghai Key Laboratory of Gastric Neoplasms, Institute Digestive Surgery, Ruijin Hospital, Jiao Tong University School Medicine, Shanghai, People's Republic China. * These authors contributed equally to this work Correspondence: Liu, email: Yang, Keywords : BGN, cancer, Metastasis, FAK Received January 1, 2014 Accepted March 24, Published 26, Abstract Biglycan (BGN) is an important member...
Biglycan (BGN) is an important component of the extracellular matrix (ECM) that implicated in a variety human cancers. In our previous study, we reported BGN was overexpressed gastric cancer (GC) tissues and promoted metastasis. Moreover, tubular formation capacity HUVECs by stimulation with culture media from BGN‐overexpressing GC cells, but exact underlying mechanism still unknown. The purpose this study to determine role molecular VEGF expression endothelial cells. We found cells...
Gastric cancer (GC) is one of the most malignant tumors and second leading cause cancer-related deaths in world. Luteolin, a flavonoid present many fruits green plants, suppresses progression. The effects luteolin on GC cells their underlying mechanisms remain unclear.Effects cell proliferation, migration, invasion, apoptosis were examined vitro vivo by counting kit-8 (CCK-8), transwell assays, flow cytometry, respectively. Real-time reverse transcription polymerase chain reaction (RT-PCR)...
microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development malignant behaviors. Accumulating evidence suggests miR-24 plays important roles in human carcinogenesis. However, its precise biological role remains largely elusive. This study examined gastric cancer (GC).The expression GC tissues compared with matched non-tumor and cells was detected qRT-PCR. Synthetic short single double stranded...
Tumor metastasis is the leading cause of death in patients with advanced gastric cancer (GC). Limited therapeutic regimens are available for this condition, which associated a poor prognosis, and mechanisms underlying tumor remain unclear. In present study, increased histone methyltransferase G9A expression GC tissues correlated stage shorter overall survival, vitro vivo experiments revealed that promoted invasion metastasis. Moreover, we observed Reg IV induced via p-ERK/p-SP1 pathway. SP1...
Papaya fruit easily decays and prematurely senescence after harvest. Studies have shown that adding ascorbic acid to chitosan can improve postharvest quality extend the shelf life of coated fruits. Therefore, effect 1.5% (w/v) (AsA), 1.0% (CTS), + (AsA CTS) treatment on storage papaya fruits was studied. The results showed AsA CTS reduced weight loss, malondialdehyde, hydrogen peroxide content fruit. improved antioxidant capacity by increasing activities enzymes (superoxide dismutase,...
// Hexiao Wang 1, * , Lei Hu Mingde Zang 1 Baogui Zhang 2 Yantao Duan Zhiyuan Fan Jianfang Li Liping Su Min Yan Zhenggang Zhu Bingya Liu Qiumeng Yang Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, 200025, People's Republic China Affiliated Hospital Jining Medical University, 272000, These authors have contributed equally to this work Correspondence to: Yang, e-mail: yangqiumeng@hotmail.com Liu,...
// Bao-gui Zhang 1, 2, * , Lei Hu Ming-de Zang He-xiao Wang 1 Wei Zhao 3 Jian-fang Li Li-ping Su Zhifeng Shao 4 Xiaodong Zheng-gang Zhu Min Yan Bingya Liu Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, Shanghai, People's Republic China 2 Affiliated Hospital Jining Medical University, Jining, Microbiology, Bio-ID Center, Biomedical Engineering, These authors have contributed equally to this work...
// Ruyuan Deng 1, * , Fengbo Mo 2, 3, Bowen Chang 4, Qi Zhang 1 Hui Ran Shuhua Yang 2 Zhiqiang Zhu 5 Lei Hu 5, 6 and Qing Su Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School Medicine, Shanghai, China Orthopaedic Surgery, Union Tongji Medical College, Huazhong Science Technology, Wuhan, 3 Surgery Massachusetts General Hospital Harvard School, Boston, MA, USA 4 Renji Anhui Provincial University, Hefei, Key Laboratory Gastric Neoplasms, Institute Digestive...
Abstract Osteoporosis (OP) is a common disease characterized by bone loss and tissue microstructure degradation. Drug treatment clinical that aims to increase mass density. Tetrahedral DNA nanostructures (TDNs) are three‐dimensional tetrahedral frames formed folding four single‐stranded molecules, which have good biological safety can promote regeneration. In this study, mouse model of OP was established ovariectomy (OVX) TDN injected into the tail vein for 8 weeks. We found ovariectomized...
Trauma is a significant global public health concern and the leading cause of morbidity mortality in children. This study aimed to assess independent predictors trauma severity as well pediatric patients admitted intensive care unit (ICU).
Obesity has recently become a prevalent health threat worldwide. Although emerging evidence suggested strong link between the pentose phosphate pathway (PPP) and obesity, role of transketolase (TKT), an enzyme in nonoxidative branch PPP that connects glycolysis, remains obscure adipose tissues. In this study, we specifically deleted TKT mouse adipocytes found no obvious phenotype upon normal diet feeding. However, adipocyte abrogation attenuated high-fat diet–induced reduced hepatic...
The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC) remains unclear, albeit exosomal circular RNA (circRNA) is known to possibly play a vital role it. We employed high-throughput sequencing techniques detect the expressions of circRNA both gefitinib-resistant and gefitinib-sensitive cells this study. circKIF20B expression was determined serum exosomes tissues patients by qRT-PCR. structure, stability, intracellular localization were verified Sanger sequencing,...
// Minlu Huang 1 , Xinjie Ma Hongpeng Shi Lei Hu Zhiyuan Fan Li Pang Zhu Xiao Yang Wei Xu Binya Liu Zhenggang and Chen Shanghai Key Laboratory of Gastric Neoplasms, Department Surgery, Institute Digestive Ruijin Hospital, Jiao Tong University School Medicine, 200025, People’s Republic China Correspondence to: Li, email: leedoctor@sina.com Keywords: FAM83D, gastric cancer, proliferation, HMMR, TPX2 Received: August 17, 2016     Accepted: June 02,...
ABSTRACT Although rapid progression and a poor prognosis in influenza A virus (IAV) infection–induced acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are frequently associated with metabolic energy disorders, the underlying mechanisms rescue strategies remain unknown. We herein demonstrated that level resting expenditure increased significantly IAV‐induced AECOPD patients cellular exhaustion emerged earlier more IAV‐infected primary COPD bronchial epithelial (pDHBE)...
The suppressive effect of chicken infectious anemia virus (CIAV) on T-lymphocyte subpopulation was evaluated in vivo by flow cytometry and dual immunostaining frozen sections. Between 14 21 days postinoculation (PI), the percentage CD4-, CD8-, CT1-positive (CD4+, CD8+, CT1+) cells significantly lower chickens infected at 1 day age with CIA-1 strain CIAV than controls. mean CD4+ thymus only 43%, whereas controls it 77%. percentages CD8+ control 54% 90%, respectively, CT1+ cells, 44% 92%,...
Asporin has been implicated as an oncogene in various types of human cancers; however, the roles asporin development and progression colorectal cancer (CRC) have not yet determined. With clinical samples, we found that was highly expressed CRC tissues compared to adjacent normal expression levels were significantly associated with lymph node metastasis status TNM stage patients. Through knockdown cell lines RKO SW620 or overexpression HT-29 LoVo, could enhance wound healing, migration...