A5023435820- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
First Affiliated Hospital of Anhui Medical University
2022-2023
Anhui Medical University
2022-2023
Influenza virus infection is one of the strongest pathogenic factors for development acute lung injury (ALI)/ respiratory distress syndrome (ARDS). However, underlying cellular and molecular mechanisms have not been clarified. In this study, we aim to investigate whether melatonin modulates macrophage polarization, oxidative stress, pyroptosis via activating Apolipoprotein E/low-density lipoprotein receptor (ApoE/LDLR) pathway in influenza A-induced ALI. Here, wild-type (WT) ApoE-/- mice...
The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC) remains unclear, albeit exosomal circular RNA (circRNA) is known to possibly play a vital role it. We employed high-throughput sequencing techniques detect the expressions of circRNA both gefitinib-resistant and gefitinib-sensitive cells this study. circKIF20B expression was determined serum exosomes tissues patients by qRT-PCR. structure, stability, intracellular localization were verified Sanger sequencing,...
Raf kinase inhibitor protein (RKIP) is an inflammation‑inhibiting mediator that involved in several diseases; however, the potential mechanism of action RKIP on inflammatory response induced by influenza A virus (IAV) remains unclear. The present study aimed to investigate whether regulated via ERK/MAPK pathway. detected expression levels and alterations human normal bronchial epithelial BEAS‑2B cells, diseased cells primary infected with IAV. Cells were treated locostatin inhibit RKIP. was...
Abstract Background The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC) remains unclear, albeit exosomal circular RNA (circRNA) is known to possiblyplay a vital role it. Methods We employed high-throughput sequencing techniques detect the expressions of exosomalcircRNA both gefitinib-resistant and -sensitive cells this study. circKIF20B expression was determined serum exosomes tissues patients by qRT-PCR. structure, stability, intracellular localization were verified...
Abstract Objective RKIP has been demonstrated as an inflammatory inhibiting mediator and involved in many diseases. However, the potential mechanism of on response induced by IAV was unclear. Methods The expression change were detected BEAS-2B, DHBE pNHBE cells infected IAV. Locostatin co-cultured with to downregulate RKIP. overexpressed transfecting lentivirus. And a small molecule inhibitor, SCH772984, specifically inhibited activation ERK/MAPK pathway. C57BL/6 mice also further confirm...