A5062208247- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Genetics and Neurodevelopmental Disorders
- Proteoglycans and glycosaminoglycans research
- Viral gastroenteritis research and epidemiology
- Cervical Cancer and HPV Research
- Nerve injury and regeneration
- Autoimmune Neurological Disorders and Treatments
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Palliative Care and End-of-Life Issues
- Chemotherapy-related skin toxicity
- Peripheral Neuropathies and Disorders
- Multiple and Secondary Primary Cancers
- Diabetes and associated disorders
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Protein Degradation and Inhibitors
- Ovarian cancer diagnosis and treatment
- Connective tissue disorders research
- Chemotherapy-induced cardiotoxicity and mitigation
University of Alabama at Birmingham
2016-2024
National Heart Lung and Blood Institute
2012
National Institutes of Health
2012
Woman's Cancer Foundation
1997
University of Washington
1997
University of Washington Medical Center
1994
Abstract Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier 1–3 . T cells, but not innate lymphoid have an indispensable sustaining IL-22 signalling that is required for protection colonic crypts against invasion during infection by enteropathogen Citrobacter rodentium 4 ( Cr ). However, epithelial cell (IEC) subsets targeted cell-derived IL-22, and how sustains activation IECs, remain undefined. Here we identify subset absorptive IECs mid–distal...
Chondroitin sulfate proteoglycans (CSPGs) play a pivotal role in many neuronal growth mechanisms including axon guidance and the modulation of repair processes following injury to spinal cord or brain. Many actions CSPGs central nervous system (CNS) are governed by specific sulfation pattern on glycosaminoglycan (GAG) chains attached CSPG core proteins. To elucidate sulfated GAG traumatic brain (TBI), controlled cortical impact mild moderate severity was performed over left sensory motor...
Levodopa-induced dyskinesia (LID) is a persistent behavioral sensitization that develops after repeated levodopa (l-DOPA) exposure in Parkinson disease patients. LID consequence of sustained changes the transcriptional behavior striatal neurons following dopaminergic stimulation. In neurons, regulation through dynamic DNA methylation has been shown pivotal to many long-term modifications; however, its role not yet explored. Using rodent model, we show development leads aberrant expression...
Abstract Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1 + CXCR5 Bcl6 CD4 will differentiate into hi GC-Tfh and how differentiation regulated. Here, we report that the sustained Tigit expression in marks precursor Tfh (pre-Tfh) to transition, whereas – upregulate IL-7Rα become memory with or without CCR7. We demonstrate pre-Tfh undergo substantial further at transcriptome chromatin accessibility levels cells. The...
1 В статье не рассматривается вопросы возможного увеличения носительства антител к ткани щитовидной железы и возрастания ее аутоиммунной патологии после аварии на ЧАЭС.Эти детально обсуждены в обзоре [35].
Abstract Chondroitin sulfate proteoglycans (CSPGs) play a pivotal role in many neuronal growth mechanisms including axon guidance and the modulation of repair processes following injury to spinal cord or brain. Many actions CSPGs central nervous system (CNS) are governed by specific sulfation pattern on glycosaminoglycan (GAG) chains attached CSPG core proteins. To elucidate sulfated GAG traumatic brain (TBI), controlled cortical impact mild moderate severity was performed over left sensory...
Abstract Interleukin (IL)-22 plays a non-redundant role in immune defense of the intestinal barrier 1–3 . We recently discovered an indispensable for T cells, but not ILCs, sustaining IL-22 signaling required protection colonic crypts against invasion during infection by enteropathogen, Citrobacter rodentium ( C.r ) 4 However, identification epithelial cell (IEC) subsets targeted cell-derived and how sustains activation IECs are undefined. Here, we identify novel subset absorptive mid-distal...
Abstract Interleukin (IL)-22 plays a non-redundant role in immune defense of the intestinal barrier 1–3 . We recently discovered an indispensable for T cells, but not ILCs, sustaining IL-22 signaling required protection colonic crypts against invasion during infection by enteropathogen, Citrobacter rodentium ( C.r ) 4 However, identification epithelial cell (IEC) subsets targeted cell-derived and how sustains activation IECs are undefined. Here, we identify novel subset absorptive mid-distal...
Abstract T follicular helper (Tfh) cells were discovered as CD4 +T in the B cell follicles that express CXCR5 and help germinal center (GC) responses. However, it is not clear which PD-1 +CXCR5 +Bcl6 +CD4 will differentiate into hiCXCR5 hiBcl6 hiGC-Tfh while others have a different fate, nor how GC-Tfh differentiation regulated. Here we report sustained Tigit expression marked precursor Tfh (pre-Tfh) to transition, whereas −PD-1 upregulated IL-7Ra become memory precursor/memory cells—with or...
Abstract Maintenance of immune homeostasis to the intestinal mictrobiota is dependent on a population effector regulatory T (eTreg) cells that develop from microbiota-reactive induced (i)Treg cells. A cardinal feature eTreg their production IL-10, which plays non-redundant role in tolerance commensal microbes. Here, we identify an unexpected for IL-2-induced Stat3 signaling program iTreg cell differentiation and Il10 transcriptional competency. IL-2 proved be both necessary sufficient...
Abstract L-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine replacement therapy with L-DOPA for the treatment of Parkinson disease (PD). The emergence LID linked to heightened sensitivity striatal dopaminergic signaling and driven by abnormal fluctuations in synaptic levels following each administration L- DOPA. This maladaptive plasticity narrows therapeutic window treatment, even as progressive worsening PD symptoms demands escalating doses....
Abstract Enteropathogenic E. coli (EPEC) is one of the leading causes diarrheal disease among children. Citrobacter rodentium (C.r) a mouse model for EPEC and neutrophils have been found to be required effective host protection against C.r. Yet details cellular sources that control neutrophil recruitment during C.r infection are poorly understood. Here we promotes limited distal colon where colonizes. induces neutrophil-recruiting chemokines CXCL1, CXCL2 CXCL5 in colon. Early (D4) intestinal...