A5101455899- Hepatocellular Carcinoma Treatment and Prognosis
- Anesthesia and Pain Management
- Cholesterol and Lipid Metabolism
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Nausea and vomiting management
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Plant biochemistry and biosynthesis
- Advanced Glycation End Products research
- Glycosylation and Glycoproteins Research
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Airway Management and Intubation Techniques
- Lipid metabolism and biosynthesis
- Phagocytosis and Immune Regulation
- Advanced MRI Techniques and Applications
- Redox biology and oxidative stress
- Turfgrass Adaptation and Management
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Dermatological and Skeletal Disorders
- IL-33, ST2, and ILC Pathways
Shanghai Jiao Tong University
2013-2024
Fudan University
2016-2023
Zhongshan Hospital
2016-2023
Shanghai Institute of Hematology
2023
The First Affiliated Hospital, Sun Yat-sen University
2017-2023
Sun Yat-sen University
2017-2023
Ministry of Education of the People's Republic of China
2023
Anhui Medical University
2023
Inner Mongolia Medical University
2013-2017
Inner Mongolia Medical College Hospital
2011-2014
// Jun Wang 1 , Ping Zhang 2 Jie Zhong Mingyue Tan Jifu Ge Le Tao Yakui Li Yemin Zhu Lifang Wu Jianxin Qiu and Xuemei Tong Department of Urology, Shanghai General Hospital, Jiao University School Medicine, Shanghai, China Biochemistry Molecular Cell Biology, Key Laboratory for Tumor Microenvironment Inflammation, Correspondence to: Tong, email: Qiu, Keywords : PFKP, aerobic glycolysis, proliferation, clear cell renal carcinoma Received September 06, 2015 Accepted March 14, 2016 Published 25,...
Abstract De novo nucleotide biosynthesis is essential for maintaining cellular pools, the suppression of which leads to genome instability. The metabolic enzyme transketolase (TKT) in nonoxidative branch pentose phosphate pathway (PPP) regulates ribose 5-phosphate (R5P) levels and de biosynthesis. TKT required cell proliferation human liver cancer lines, yet role injury initiation remains be elucidated. In this study, we generated a liver-specific knockout mouse strain by crossing...
Abstract Inflammatory bowel disease (IBD) has a close association with transketolase (TKT) that links glycolysis and the pentose phosphate pathway (PPP). However, how TKT functions in intestinal epithelium remains to be elucidated. To address this question, we specifically delete epithelial cells (IECs). IEC TKT-deficient mice are growth retarded suffer from spontaneous colitis. ablation brings about striking alterations of intestine, including extensive mucosal erosion, aberrant tight...
Obesity has recently become a prevalent health threat worldwide. Although emerging evidence suggested strong link between the pentose phosphate pathway (PPP) and obesity, role of transketolase (TKT), an enzyme in nonoxidative branch PPP that connects glycolysis, remains obscure adipose tissues. In this study, we specifically deleted TKT mouse adipocytes found no obvious phenotype upon normal diet feeding. However, adipocyte abrogation attenuated high-fat diet–induced reduced hepatic...
// Xiao-Yun Zhang 1, * , Minle Li 2, Kai Sun Xiao-Jie Chen 1 Jian Meng 2 Lifang Wu Ping Xuemei Tong Wei-Wen Jiang Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Jiao University School Medicine, 200011, China Biochemistry and Molecular Cell Biology, Key Laboratory for Tumor Microenvironment Inflammation, 200025, These authors contributed equally to this work Correspondence to: Jiang, e-mail: wwjiang33@hotmail.com Tong, xuemeitong@shsmu.edu.cn Keywords: GRIM-19,...
Purpose To assess the accuracy of T 1 relaxation time index on gadoxetic acid‐enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B (CHB), comparison and combination with aspartate aminotransferase‐to‐platelet ratio (APRI) fibrosis‐4 (FIB‐4). Materials Methods A retrospective study mapping serum biochemical tests was performed 126 CHB patients who underwent 1.5T MRI, histological score used as gold standard. The reduction rate before 20 minutes after...
Abstract Transcription factor carbohydrate responsive element binding protein (ChREBP) promotes glycolysis and lipogenesis in metabolic tissues cancer cells. ChREBP-α ChREBP-β, two isoforms of ChREBP transcribed from different promoters, are both transcriptionally induced by glucose. However, the mechanism which glucose increases mRNA levels remains unclear. Here we report that hepatocyte nuclear 4 alpha (HNF-4α) is a key transcription for glucose-induced ChREBP-β expression. Ectopic HNF-4α...
To explore the threshold of intravoxel incoherent motion (IVIM) parameters, apparent diffusion coefficient [ADCtotal and ADC(0,500) ] ratios 24-48 hours after transarterial chemoembolization (TACE) to assess early response in patients with unresectable hepatocellular carcinoma (HCC) compare association between diffusion-weighted imaging (IVIM-DWI) mRECIST survival.Institutional Review Board approval informed consent were obtained for this prospective study. There 30 undergoing 1.5T magnetic...
The aim of the study was to elucidate mechanism by which advanced glycation end products (AGEs) promote cell proliferation in liver cancer cells. We treated HepG2 cells with 200 mg/L AGEs or bovine serum albumin (BSA) and assayed for viability, cycle, apoptosis. performed real-time PCR Western blot analysis RNA protein levels carbohydrate responsive element-binding (ChREBP) AGEs- BSA-treated analyzed level reactive oxygen species (ROS) BSA. found that increased S-phase percentage decreased...
The aim of the present study was to investigate effects target-controlled infusion (TCI) propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding surgical field. 62 patients scheduled undergo FESS were randomly divided into experimental group (intravenous 0.5 µg kg-1 h-1 after bolus within 15 min until end surgery) or control saline administration at same dose). All underwent endotracheal intubation under general anesthesia TCI for...
Abstract Deregulated metabolism is one of the characteristics hepatocellular carcinoma. Sex hormone receptor signalling has been involved in marked gender dimorphism carcinoma pathogenesis. Oestrogen (ER) reported to reduce incidence liver cancer. However, it remains unclear how oestrogen and ER regulate metabolic alterations tumour cells. Our previous work revealed that ERα interacted with carbohydrate responsive element binding protein (ChREBP), which a transcription factor promoting...
The Mondo family transcription factor MondoA plays a pivotal role in sensing metabolites, such as glucose, glutamine, and lactic acid, to regulate glucose metabolism cell proliferation. Ketone bodies are important signals for reducing uptake. However, it is unclear whether functions ketone body-regulated transport. Here we reported that promoted nuclear translocation binding the promoter of its target gene TXNIP. reduced uptake, increased apoptosis decreased proliferation colorectal cancer...
Most solid tumors show increased interstitial fluid pressure (IFP), and this IFP is an obstacle to treatment. A noninvasive model for measuring in hepatocellular carcinoma (HCC) unresolved issue.To develop a measure velocity (IFV) HCC characterize the microvascular invasion (MVI) status by using model.Retrospective.A total of 97 patients (mean age 57.6 ± 10.9 years, 77.3% males), 53 them with MVI 44 without MVI.A 3-T, three-dimensional spoiled gradient-recalled echo.MVI was defined as...