A5101703834- Marine Sponges and Natural Products
- Cancer-related molecular mechanisms research
- Phosphodiesterase function and regulation
- Synthesis and Catalytic Reactions
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Microbial Natural Products and Biosynthesis
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Marine Biology and Environmental Chemistry
- Pulmonary Hypertension Research and Treatments
- Colorectal Cancer Screening and Detection
- Thyroid Cancer Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- GDF15 and Related Biomarkers
- Rabies epidemiology and control
- Ginger and Zingiberaceae research
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
Wenzhou Medical University
2022-2025
Fudan University Shanghai Cancer Center
2015-2023
Shanghai Medical College of Fudan University
2015-2023
GEOMAR Helmholtz Centre for Ocean Research Kiel
2019-2022
Henan Agricultural University
2021
University of Chicago
2021
Henan University
2020-2021
National Health Research Institutes
2021
Zhejiang Cancer Hospital
2020
Cancer Hospital of Chinese Academy of Medical Sciences
2020
High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported colorectal cancer patients; however, its' clinical significance and origin are unclear. We evaluated diagnostic prognostic value, NEAT1 cancer. Expression variants, NEAT1_v1 NEAT1_v2 were determined using real-time quantitative PCR. The value was test (n = 60) validation 200) cohorts patients normal controls (NCs). To identify NEAT1, its analyzed blood, matched primary...
Abstract Sponges host a remarkable diversity of microbial symbionts, however, the benefit their microbes provide is rarely understood. Here, we describe two new sponge species from deep-sea asphalt seeps and show that they live in nutritional symbiosis with methane-oxidizing (MOX) bacteria. Metagenomics imaging analyses revealed unusually high amounts MOX symbionts hosts group previously assumed to have low abundances. These belonged Marine Methylotrophic Group 2 clade. They are...
Copper (Cu) is a trace element necessary in animals as well human beings. However, excessive Cu toxic to immunocytes, but the precise mechanism largely unclear so far. This work was conducted aiming examine Cu-mediated autophagy together with its role toxicology RAW264.7 cells. Here, we demonstrated that CuSO4 reduced cell viability depending on dose. could obviously increase According obtained results, induced through Akt/AMPK/mTOR pathway which characterized by down regulation of p-Akt...
Recent evidence indicates that inflammatory parameters could be useful to predict metastasis from colorectal cancer. However, their roles in predicting chemotherapy response and prognosis patients with synchronous liver (CLM) are unknown.The clinical data baseline laboratory of 55 CLM were retrospectively reviewed. All underwent palliative resection the primary tumor oxaliplatin-based chemotherapy. Two indices systemic inflammation reviewed-neutrophil-to-lymphocyte ratio (NLR)...
Background: Both AJCC 7th and 8th TNM systems have included tumor deposits (TDs) in nodal staging when lymph nodes metastases (LNMs) are negative colorectal cancer (CRC). However, the prognostic role of TDs has not been determined presence positive LNMs. Methods: Two independent large-scale cohorts CRC patients from Surveillance Epidemiology End Results (SEER) database (n=69,178) [2010–2013] Fudan University Shanghai Cancer Center (FUSCC) (n=3,137) [2010–2014] were retrospectively analyzed....
Anastomotic leakage is still one of the most dreaded complications after anterior resection for rectal cancer. This study aimed to identify risk factors anastomotic and create a nomogram precise prediction cancer.Two thousand six hundred eighteen consecutive patients who underwent cancer with primary anastomosis, or without diverting stoma, were retrospectively analyzed as training dataset. Univariate multivariable Cox regression analyses used determine independent associated leakage. A was...
Abstract Upon injury, the homeostatic balance that ensures tissue function is disrupted. Wound-induced signaling triggers recovery of integrity and offers a context to understand molecular mechanisms for restoring homeostasis upon disturbances. Marine sessile animals are particularly vulnerable chronic wounds caused by grazers can compromise prey’s health. Yet, in comparison other stressors like warming or acidification, we know little on how marine respond grazing. sponges (Phylum Porifera)...
Non-small cell lung cancer (NSCLC) is the most common subtype of cancer, and prognosis poor due to distant metastasis. Thus, there an urgent need discover novel therapeutic targets strategies overcome A series in vitro vivo phenotype experiments were performed investigate role PDE1A NSCLC. The RIP assay, mRNA stability assay LC-MS/MS molecular mechanisms NSCLC progression. We demonstrated that phosphodiesterase 1A (PDE1A) promoted metastasis EMT progression In addition, cells overexpressing...
Temporary diverting stoma might be a protective factor for the prevention of anastomotic leakage (AL) after anterior resection. Its role in recovery is unknown. This study aimed to evaluate effect temporary on severity and recovery. We analyzed 323 patients who underwent resection rectal cancer developed leakage, which 44 had stoma. Association between occurrence time, length hospital stay, overall costs, local distant relapse-free survival were further studied. In non-severe AL group,...
Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress activates unfolded protein response pathways, which drives GDF15 expression cancer cells. Mechanistically, upregulated CHOP led by activated PERK-eIF2α signaling promotes transcription via directly binding to its promoter....
Rectovaginal fistula is a postoperative complication of low anterior resection. We investigated the incidence rectovaginal (RVF) after resection, its risk factors and optimal treatment. analyzed data from 1,493 female patients who underwent resection for colorectal cancer between January 2006 March 2016. calculated RVF performed univariate multivariate logistic regression analyses to identify factors. Twenty-four experienced RVF, giving an 1.61%. Univariate analysis revealed short distance...
Pleural effusion is a rare immune-related adverse event for lung cancer patients receiving immune checkpoint inhibitors (ICIs). We enrolled 281 treated with ICIs and 17 were analyzed. categorized the formation of pleural into 3 patterns: type 1, rapid massive; 2, slow indolent; 3, disease progression. CD4/CD8 ratio 1.93 was selected as cutoff threshold to predict survival. Most types 1 2 effusions possessed ratios ≥ 1.93. The median OS time in not reached, 24.8, 2.6 months, respectively. PFS...
Thyroid metastases from colorectal cancer (CRC) are rare, both in clinical practice and the literature; hence, their diagnosis, appropriate treatment, prognostic factors require further investigations. A retrospective analysis was performed for four cases of thyroid CRC, treated our center between January 2005 December 2015, relevant literature searched using PubMed, resulting identification 17 patients with detailed information available. The data follow-up previously reported were...
Sponges are one of the most dominant organisms in marine ecosystems. One reason for their success is association with microorganisms that besides host itself responsible chemical defence. Sponge abundances have been increasing on coral reefs Western Indian Ocean (WIO) and predicted to increase further rising anthropogenic impacts reefs. However, there a paucity information ecology sponges from WIO prokaryotic community composition. We used combination Illumina sequencing predictive...
Background:The clinical significance of KRAS exon 3/4 mutations in colorectal cancer (CRC) remains unclear.We aimed to assess the prognostic value exons 3 and 4 determine necessity for their testing.Methods: 2/3/4 were evaluated 1816 stage I-IV patients with adenocarcinoma.Results: The mutation rates 2, 3, 49.0%, 43.0%, 1.9%, 4.1%, respectively.Univariate survival analysis showed that had worse overall (OS) compared those 2 or wild-type (P = 0.044, P 0.001).Meanwhile, there was no difference...
Gastric cancer (GC) is one of the most common malignant neoplasms and third leading cause cancer-related death around world. Metformin has been well reported to have an inhibitory effect on growth various cancers by regulating expression microRNAs (miRNAs). However, specific miRNA(s) regulated metformin in GC not identified. In this study, real-time reverse transcription polymerase chain reaction (RT-PCR) analysis vitro indicated that miR-107 was up-regulated metformin-treated SGC-7901 cells...
Sponges thrive in marine benthic communities due to their specific and diverse chemical arsenal against predators competitors. Yet, some animals specifically overcome these defences use sponges as food home. Most research on sponge ecology has characterised crude extracts investigated generalist like fish. Consequently, we know little about dynamics the tissue responses specialist grazers. Here, studied response of Aplysina aerophoba grazing by opisthobranch Tylodina perversa, comparison...