A5100405769- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Hepatitis C virus research
- Sulfur Compounds in Biology
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Bone fractures and treatments
- Hepatitis B Virus Studies
- Sleep and Wakefulness Research
- Genetic Associations and Epidemiology
- Chronic Kidney Disease and Diabetes
- Biomedical Research and Pathophysiology
- Autophagy in Disease and Therapy
- Disaster Management and Resilience
- Maritime Navigation and Safety
- Medication Adherence and Compliance
- Antifungal resistance and susceptibility
- Epigenetics and DNA Methylation
- Lipid metabolism and disorders
- Cancer Mechanisms and Therapy
University of Electronic Science and Technology of China
2025
Craft Group (China)
2024
University of South China
2019-2024
Shanghai Jiao Tong University
2024
The Netherlands Cancer Institute
2023
Shandong University
2012-2023
Shangqiu Normal University
2023
Qilu Hospital of Shandong University
2019-2023
Shaanxi University of Chinese Medicine
2023
Air Force Medical University
2023
Background Glioblastoma (GBM), one of the most aggressive tumors brain, has no effective or sufficient therapies. Identifying robust biomarkers for response to immune checkpoint blockade (ICB) therapy, a promising treatment option GBM patients, is urgently needed. Methods We comprehensively evaluated lncRNA m 6 A modification patterns in A-sequencing (m A-seq) data tissues and systematically investigated stromal regulators these A-regulated lncRNAs. used single-sample gene-set enrichment...
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common disorder and frequently exacerbates in postmenopausal women. In NAFLD, endoplasmic reticulum (ER) plays an important role lipid metabolism, which salubrinal a selective inhibitor of eIF2α de-phosphorylation response to ER stress. To determine potential mechanism obesity-induced we employed evaluated effect stress autophagy on metabolism. Ninety-five female C57BL/6 mice were randomly divided into five groups: standard chow...
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers.Down-regulation PI3K/Akt pathway has been described as related reversal MDR in cancer cells.Here, we investigated effect on phenotype perifosine, a new Akt inhibitor, cell lines.In this study, MCF-7/ADM cells and MCF-7 were treated with different concentrations perifosine.Our results suggested that perifosine reversed partially by downregulation P-gp expression...
Background An increasing number of RNA modification types other than N 6 -methyladenosine (m A) have been detected. Nonetheless, the probable functions modifications beyond m A in tumor microenvironment (TME), mesenchymal (MES) transition, immunotherapy, and drug sensitivity remain unclear. Methods We analyzed characteristics 32 non-m regulators 539 glioblastoma (GBM) patients TME cell infiltration MES transition patterns. Using principal component analysis, a epitranscriptome regulator...
DNA methylation is catalyzed and maintained by methyltransferases (DNMTs: DNMT1, DNMT3A DNMT3B) methyl-CpG-binding domain protein 2 (MBD2). However, little known about the biological clinical significance of expression changes DNMTs MBD2 their association with levels long interspersed nuclear element-1 (LINE-1) in patients tetralogy Fallot (TOF). In this study, quantitative RT-PCR (qRT-PCR) was applied to analyze mRNA MBD2. The status LINE-1 measured using sequenom MassARRAY platform. showed...
Our previous studies have reported that hydrogen sulfide (H2S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown. Recent research reveals Warburg effect is associated with synaptic plasticity which plays a key role in cognition promotion. Herein, present study was aimed demonstrate whether hippocampal contributes H2S-ameliorated DACD and further explore its potential mechanism. We found H2S promoted inhibited OxPhos hippocampus...
High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding basic mechanisms injury repair. A metabolite profiling approach was employed determine associations between alterations in serum metabolites histology patients with chronic hepatitis C virus (HCV) infection.Sera from 45 non-diabetic HCV were quantitatively analyzed using (1)H-NMR spectroscopy. profile advanced fibrosis (METAVIR F3-4) established orthogonal...
SUMMARY OBJECTIVE To investigate the clinical efficacy and possible mechanisms of saxagliptin in treatment type 2 diabetes mellitus (T2DM) combined with non-alcoholic fatty liver disease (NAFLD). METHODS A total 95 T2DM NAFLD patients were randomly divided into group (saxagliptin group), B (glimepiride C polyene phosphatidylcholine group). RESULTS After intervention for 24 w, body mass index (BMI), waist-to-hip ratio (WHR), glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), insulin...
Based on ancient classics, Danzhi Tiaozhi Decoction has been successfully used to treat nonalcoholic fatty liver disease for decades. However, its therapeutic mechanisms remain unclear.This study aimed investigate the effects of (DZTZD) metabolic-associated (MAFLD).First, we identified active ingredients DZTZD and their potential targets in Traditional Chinese Medicine System Pharmacology database. Using overlapped genes, selected key MAFLD-associated then conducted GO KEGG pathway...
This paper examines the past and current research in container port maritime field. Using rigorous bibliometric analysis, identifies core authors/affiliations, their rankings, collaboration patterns. The analysis of will enable new researchers to quickly build an understanding field by reading authors’ papers published specific journals.
Background and Aim: Accumulation of β2-microglobulin (B2M), a systemic pro-aging factor, regulates negatively cognitive function. Hydrogen sulfide (H2S), novel gas signaling molecule, exerts protection against dysfunction. Therefore, the present work was designed to explore whether H2S attenuates dysfunction induced by B2M its underlying mechanism. Materials Methods: The function rats assessed Y-maze, Novel object recognition (NOR), Morris water maze (MWM) tests. levels autophagosome...
To evaluate the utility of Golgi protein 73 (GP73) in diagnosis non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) staging.
Objective: San-cao Granule (SCG), a traditional Chinese herb formula, has been used for treating autoimmune hepatitis (AIH) in our clinics long time. However, its active ingredients and mechanisms of action were still unknown due to complicated chemical compositions. In the present study, pharmacological study SCG on acute liver injury induced by Concanavalin A (Con A) was performed provide scientific evidence against injury. Methods: order screen components predicate action, an...
Nonalcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide, and it has no effective treatment. We previously reported that native polypeptide vglycin (purified from soybean) a beneficial role in regulating glucose homeostasis diabetic rats. In this study, we investigated preventive effects possible mechanisms action hepatic steatosis using high-fat diet (HFD)-induced mouse model. The results revealed decreased body weight, Lee's index, plasma triglyceride level...
To explore relationships between polyunsaturated fatty acids (PUFA) and non-alcoholic liver disease (NAFLD) in patients with type 2 diabetes, whether insulin action has an interactive effect PUFA on NAFLD progression.We extracted clinical omics data of 482 diabetes from a tertiary hospital consecutively April 2018 to 2019. was estimated by ultrasound at admission. Plasma fasting n3 n6 were quantified liquid chromatography-tandem mass spectrometry analysis. Restricted cubic spline nested...