A5056424713- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Microtubule and mitosis dynamics
- Cardiac electrophysiology and arrhythmias
- Respiratory viral infections research
- Metabolomics and Mass Spectrometry Studies
- Customer Service Quality and Loyalty
- RNA modifications and cancer
- Effects and risks of endocrine disrupting chemicals
- RNA Research and Splicing
- Customer churn and segmentation
- Congenital Diaphragmatic Hernia Studies
- Animal testing and alternatives
- Diet and metabolism studies
- Ion channel regulation and function
- Food composition and properties
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Catalysis for Biomass Conversion
- MicroRNA in disease regulation
- Consumer Retail Behavior Studies
- Meat and Animal Product Quality
- Cancer, Lipids, and Metabolism
Qilu Hospital of Shandong University
2019-2024
First Affiliated Hospital of Xi'an Jiaotong University
2020-2024
Beijing Anzhen Hospital
2022-2024
Tianjin University of Technology
2023-2024
Capital Medical University
2022-2024
Soochow University
2024
Dalian Medical University
2024
Minzu University of China
2023
Sichuan Agricultural University
2020-2023
Ministry of Agriculture and Rural Affairs
2023
Background: The need for mechanistic understanding of nonmonotonic dose responses has been identified as one the major data gaps in study bisphenol A (BPA). Previously we reported that acute exposure to BPA promotes arrhythmogenesis female hearts through alteration myocyte Ca2+ handling, and response was inverted U-shaped.Objective: We sought define cellular mechanism underlying heart.Methods: examined rapid effects rat ventricular myocytes using video-edge detection, confocal conventional...
Bisphenol S (BPS) has increasingly been used as a substitute for bisphenol A (BPA) in some "BPA-free" consumer goods and thermal papers. Wide human exposure to BPS reported; however, the biological potential toxic effects of are poorly understood.In this study, we sought elucidate sex-specific rapid effect rat hearts its underlying mechanism.We examined using electrophysiology, confocal conventional fluorescence imaging, immunoblotting. Treatment was administered via acute perfusion excised...
Although the Indian Ocean dipole (IOD) and ENSO are significantly correlated, there indeed some IODs independent of ENSO. In this research, characteristics IOD investigated a new triggering mechanism is proposed based on case study statistical analysis. Results show that peak in an earlier season have weaker intensity compared with associated The wind anomaly very unique shows monsoonlike pattern, addition to equatorial easterly (EEWA) common all IODs. evolution EEWA well captured by second...
Previously we showed that bisphenol A (BPA), an environmental estrogenic endocrine disruptor, rapidly altered Ca2+ handling and promoted arrhythmias in female rat hearts. The underlying molecular mechanism was not known. Here examined the cardiac-specific signaling mediating rapid impact of low-dose BPA ventricular myocytes. We protein kinase (PKA) Ca2+/CaM-dependent II (CAMKII) pathways are two major activated by BPA. Exposure to 1 nM increased production cAMP but transiently...
Abstract Nitric oxide (NO) is a highly reactive gaseous small molecule that regulates plant growth. Sodium nitroprusside (SNP) was used as an NO donor to study the effects of treatment on browning and antioxidant activity button mushrooms ( Agaricus bisporus ). The findings revealed exogenous alleviated browning, decreased hardness, increased weight loss stored at 4°C for 15 days, reduced accumulation oxygen species membrane lipid peroxidation. Moreover, dramatically anabolism endogenous NO,...
To detect the expression of Toll-like receptor 4 (TLR-4) and NF-κB to discuss mechanism TLR-4/NF-κB pathway in myocardial ischemia reperfusion injury mouse.TLR-4 mutant mice wild homozygous were divided into model group sham group. Mice given ligation left anterior descending coronary artery for modeling, while not after threading. The cardiac muscle tissues collected morphological observation. immunohistochemistry was employed NF-κB, Western blot used TLR-4 ELISA serum inflammatory...
Abstract Regulation of intracellular pH (pH i ) in cardiomyocytes is crucial for cardiac function; however, currently known mechanisms direct or indirect extrusion acid from seem insufficient energetically efficient the massive H + loads generated under vivo conditions. In cardiomyocytes, voltage‐sensitive channel activity mediated by HVCN1 proton would be a highly means disposing , while avoiding Na loading, as occurs during via /H exchange –HCO 3 − cotransport. PCR and immunoblotting...
Multiple cancers have been reported to be associated with angiogenesis and are sensitive anti-angiogenic therapies. Vascular normalization, by restoring proper tumor perfusion oxygenation, could limit cell invasiveness improve the effectiveness of anticancer treatments. However, underlying mechanisms antiangiogenic drugs still unknown. Metformin (MET) simvastatin (SVA), two metabolic-related drugs, shown play important roles in modulating hypoxic microenvironment angiogenesis. Whether...
A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death dilated cardiomyopathy. However, precise mechanisms affecting SR function leading arrhythmias remain elusive.We generated transgenic mice with cardiac-specific expression of Ala96 HRC or Ser96 null background assess absence endogenous protein. decreased (25% 30%) cardiomyocyte contractility Ca2+ kinetics compared any...
Background Necroptosis is considered to be a new form of programmed necrotic cell death, which associated with metastasis, progression and prognosis various types tumors. However, the potential role necroptosis-related genes (NRGs) in triple negative breast cancer (TNBC) unclear. Methods We extracted gene expression relevant clinicopathological data TNBC from The Cancer Genome Atlas (TCGA) databases Gene Expression Omnibus (GEO) databases. analyzed expression, somatic mutation, copy number...
Background: As a highly prevalent malignancy among women worldwide, breast cancer, remains critical public health issue necessitating the development of novel therapeutics and biomarkers. Kruppel Like Factor 2 (KLF2), member family transcription factors, has been implicated in various types cancer due to its diminished expression; however, potential implications KLF2 expression relation progression, prognosis, therapy remain unclear. Methods: The present study employed Tumor Immune...
Tumor-derived exosomes bind to organ resident cells, activating S100 molecules during the remodeling of local immune microenvironment. However, little is known regarding how cell S100A10 mediates cancer metastatic progression. Here, we provided evidence that plays an important role in regulating lung microenvironment and metastasis. S100A10-deficient mice reduced metastasis lung. Furthermore, activation within fibroblasts via tumor-derived increased expression CXCL1 CXCL8 chemokines,...
To investigate the effects of dietary starch structure (amylose/amylopectin ratio, AR) on serum glucose absorption metabolism and intestinal health, a total ninety weaned piglets (Duroc × (Yorkshire Landrace)) were randomly assigned to 5 treatments fed with diet containing different AR (2.90, 1.46, 0.68, 0.31, 0.14). The trial lasted for 21 d. In this study, growth performance was not affected by (p > 0.05). Diets higher amylose ratios (i.e., 2.90 1.46) led significant reduction...
Objectives This study aimed to assess the association between plasma glutamate (Glu) and risk of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) whether this differs by gender. Material methods We retrieved clinical information on 1032 consecutive T2DM from a same tertiary care center May 2015 August 2016. Glu was quantified liquid chromatography-tandem mass spectrometry analysis. converted into categorical variable based median concentration whole population,...
The selective production of C4 bulk chemicals from biomass is significant to replace the traditional method petroleum resource. In this work, succinic anhydride (SAN) directly prepared bio-based furanic platform compounds utilizing visible light-induced oxygenation process, in which m-tetraphenyl porphyrin (H2TPP) and molecular oxygen was employed as photocatalyst terminal oxidant, respectively. Under optimal conditions, a 99.9% conversion with 97.8% selectivity SAN obtained furoic acid...
Diabetic retinopathy is a common complication of type 2 diabetes mellitus (T2DM). Due to the limited effectiveness current prevention and treatment methods, new biomarkers are urgently needed for diagnosis DR. This study aimed explore relationships between plasma acylcarnitine with DR in T2DM.From May 2015 August 2016, data 1032 T2DM patients were extracted from tertiary hospitals. Potential non-linear associations tested by binary logistic regression models, ORs 95% CIs research variables...
This study aimed to explore the relationship between homocysteine (Hcy) and diabetic retinopathy (DR) impacts of Hcy pathway on this against background.This retrieved 1979 patients with type 2 diabetes (T2D) from First Affiliated Hospital Liaoning Medical University in Jinzhou, Province, China. Multiple logistic regression was used analyze effects cycle DR. Spearman's rank correlation analysis risk factors related DR progression Hcy. Finally, results were supplemented by mediation...
Background High-fat diet (HFD)-induced hyperlipidemia, which is associated with gut microbiota disturbances, remains a major public health challenge. Glycerolipid metabolism responsible for lipid synthesis and thus involved in the development of hyperlipidemia. However, possible association between HFD-modulated microbiome glycerolipid pathway unclear. Methods Hamsters were fed HFD 4 weeks to establish hyperlipidemia model. Fecal, plasma liver samples collected from hamsters or normal chow...
Catalytic transformation of biomass resources to synthesize the value-added C4 chemicals has attracted wide attention in catalysis field. In this work, with metal organic frameworks (MOFs) as heterogeneous catalyst, biobased furans including furoic acid (FAC) and furfuryl alcohol (FAL) were selectively transformed 5-hydroxy-2(5H)-furanone (HFO) succinic anhydride (SAN) presence molecular oxygen. For instance, a 99.0% conversion 95.6% selectivity SAN was obtained by using Hf-TCPP...
Background Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality globally. Hypercholesterolemia accelerates atherosclerotic development and an independent modifiable risk factor for ASCVD. Reducing cholesterol levels effective in preventing Acetyl-L-carnitine (ALC) endogenous molecule that plays a primary role energy metabolism; however, its effect on metabolism remains unclear. Methods We collected plasma samples clinical data from 494 individuals with...